Motoaki Ozaki

Colchicine in the treatment of the cutaneous manifestations of Behçet's disease

Five patients with Behçets disease were satisfactorily treated with colchicine. Oral aphthosis, erythema nodosum‐like lesions and genital erosions improved greatly within a month as did laboratory findings. We believe colchicine to be the first choice in the management of the cutaneous and ocular lesions of Behçets disease.

Topical 8-methoxypsoralen photochemotherapy of psoriasis: a clinical study.

Topical psoralen plus UV‐A irradiation (topical PUVA) was re‐evaluated with regard to the timing of UV‐A exposure. Symmetrical lesions of fifteen patients with psoriasis were treated with topical PUVA. One side was exposed to UV‐A 2 h after topical application of 1% 8‐methoxypsoralen (2‐h interval therapy), while the other side was exposed to the same doye of UV‐A within 5 min of the topical application (non‐interval therapy). Both regimens were effective. The non‐interval therapy was preferred in one ease, the 2‐hour interval was preferred in three cases, and there was no clear difference in the other eleven cases. There was less tendency to burning with the non‐interval therapy, and our study suggests that this is a useful regimen in the out‐patient treatment of psoriasis.

Bullous Pemphigoid Associated with Radiotherapy for Esophageal Carcinoma

The authors present a case of bullous pemphigoid occurring after radiotherapy for esophageal cancer which was histologically squamous cell carcinoma revealed by the postmortem examination. To our knowledge, such a coexistence may be the first case.

Familial lichen amyloidosis

ABSTRACT: In japan, two cases of familial lichen amyloidosis were found in a mother and her son, who had a history of cutaneous amyloidosis in 11 adults of three family generations. HLA types in both patients were rather common ones among Japanese people. Topical application of dimethyl sulfoxide was effective in the mother but not in the son. Familial cutaneous amyloidosis (FCA) is a rare disease in japan although nonfamilial‐type is not uncommon. Possible parameters of FCA are disc ussed. The author recommends using “FCA” without “primary” as the name of the disease.

Lepromatous Leprosy Complicated with Systemic Lupus erythematosus

This paper presents a case of lepromatous leprosy complicated with systemic lupus erythematosus and diagnosed as having typical systemic lupus erythematosus from clinical features and results of laboratory tests. We discuss the appearance of autoantibodies in systemic lupus erythematosus as well as in leprosy.

Evaluation of circulating immune complexes and antinuclear antibodies in Japanese patients with leprosy

SummaryIn 79 patients with leprosy a significant increase of anti-extractable nuclear antigen (ENA) antibodies and circulating immune complexes (CIC) was found. No correlation between CIC and anti-ENA antibodies was demonstrable. Since such a correlation is known from antinuclear antibodies and CIC in patients with systemic lupus erythematosus, it appears likely that anti-ENA antibodies do not play a causative role in CIC-mediated pathogenesis of leprosy.

Trichilemmal neoplasm developing in seborrheic keratosis--report of two cases.

Granulation‐like, flesh colored tumors developed in the verrucous plaques of a 70‐year‐old man and a 86‐year‐old man. The verrucous plaques, which had appeared more than 15 or 20 years earlier, were found to be a common type of seborrheic keratosis. The newly appearing tumors histologically consisted of large, glycogen‐rich, clear epidermal cells and surrounding basaloid cells, resulting in multilobular architecture. Dyskeratotic cells and parakeratotic plugs showing trichilemmal keratinization were present in both cases. Bowenoid changes were seen in a part of the plaque from one case, and many mitotic cells and an invading figure in the tumorous cells of the other. These cases demonstrate the rare possibility of trichilemmal neoplasms developing in a common type of seborrheic keratosis.

Acantholytic Dyskeratosis on Both Legs

A 33-year-old woman developed pruritic lesions on both legs. There were brownish-red keratotic papules, whose biopsy specimen showed acantholysis and benign dyskeratosis. The duration was approximately 8 years. We considered her as a case of persistent acantholytic dermatosis with atypical distribution.

Extensive Variant of Cutaneous Amyloidosis: Report of a Case with Electron-Microscopic and Immunohistochemical Studies of the Basement Membrane Zone at Sites of Amyloid Production

A 60-year-old Japanese female developed widespread lichenoid eruptions with pigmentation, which initially appeared in preceding erythematous skin lesions due to dermatomyositis. Thioflavine T and Dylon stainings, electron microscopy and immunohistochemistry revealed that thick amyloid deposits were present in the papillary dermis particularly beneath the epidermis. Autopsy showed no evidence of systemic amyloidosis. Electron microscopy of the lesional skin disclosed the disturbance of lamina densa formation in the epidermal basement membrane zone (BMZ). There was disruption and dissociation of the lamina densa from the basal cell, and a lamina-densa-like substance was found in the amyloid deposits. Immunofluorescence and immunoelectron microscopy showed that type IV and VII collagens, LDA-1 antigen (a noncollagenous component of the BMZ) and laminin were distributed in irregular thick deposits along the BMZ and were also present within the amyloid itself. These findings indicate that morphological and immunohistochemical abnormalities of the lamina densa may be involved in amyloid production at the interface of the epidermis and dermis, at least in this case.

Necrobiosis-Lipoidica-Like Skin Manifestation in Lymphomatoid Granulomatosis (Liebow)

A 58-year-old man developed 3 indurative erythematous lesions like necrobiosis lipoidica on the right lower leg. He had had similar cutaneous lesions 1.5 years previously. These had been surgically excised, and a histologic diagnosis of necrobiosis lipoidica was made at another hospital. He was diagnosed as having lymphomatoid granulomatosis by lung biopsy in our hospital. Nasal involvement was confirmed in later examinations and the skin lesions were also considered to be the cutaneous manifestation of lymphomatoid granulomatosis. This outlines that cutaneous manifestations may allow early diagnosis of lymphomatoid granulomatosis.