Motohiro Itotani
Otsuka Pharmaceutical
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Featured researches published by Motohiro Itotani.
Current Topics in Medicinal Chemistry | 2007
Makoto Matsumoto; Hiroyuki Hashizume; Hidetsugu Tsubouchi; Hirofumi Sasaki; Motohiro Itotani; Hideaki Kuroda; Tatsuo Tomishige; Masanori Kawasaki; Makoto Komatsu
The challenges in preventing and controlling tuberculosis are further complicated by the deadly rise of multi-drug-resistant tuberculosis (MDR-TB). Recognizing the seriousness of the situation, we initiated a program to screen new agents that would satisfy these unmet needs and have a favorable safety profile. Mycobacteria are well known for their lipid-rich properties. In Mycobacterium tuberculosis, mycolic acid in particular has been established the wall component related to the pathogenesis in the host. There are approximately 250 identified genes related to biosynthesis of the lipid turnover that contain InhA, the main target of isoniazid. Thus, the logical approach for developing a chemotherapy agent against tubercle bacilli included screening compounds that could inhibit the biosyntheses of mycolic acid and that had a novel chemical structure to ensure improved efficacy against MDR-TB. Some of the screening systems established for those purposes and some of the candidates are outlined.
Journal of Medicinal Chemistry | 2006
Hirofumi Sasaki; Yoshikazu Haraguchi; Motohiro Itotani; Hideaki Kuroda; Hiroyuki Hashizume; Tatsuo Tomishige; Masanori Kawasaki; Makoto Matsumoto; Makoto Komatsu; Hidetsugu Tsubouchi
Archive | 2003
Hidetsugu Tsubouchi; Hirofumi Sasaki; Hideaki Kuroda; Motohiro Itotani; Takeshi Hasegawa; Yoshikazu Haraguchi; Takeshi Kuroda; Takayuki Matsuzaki; Kuninori Tai; Makoto Komatsu; Makoto Matsumoto; Hiroyuki Hashizume; Tatsuo Tomishige; Yuji Seike; Masanori Kawasaki; Takumi Sumida; Shin Miyamura
Archive | 2006
Hiroshi Yamashita; Hideaki Kuroda; Nobuaki Ito; Shin Miyamura; Kunio Oshima; Jun Matsubara; Haruka Takahashi; Tae Fukushima; Satoshi Shimizu; Kazumi Kondo; Yohji Sakurai; Takeshi Kuroda; Shinichi Taira; Motohiro Itotani; Tatsuyoshi Tanaka
Archive | 2004
Hidetsugu Tsubouchi; Hirofumi Sasaki; Motohiro Itotani; Yoshikazu Haraguchi; Shin Aza Kitakawamukai Ninokoshi Miyamura; Makoto Matsumoto; Hiroyuki Hashizume; Tatsuo Tomishige; Masanori Kawasaki; Kinue Ohguro; Takumi Sumida; Takeshi Hasegawa; Kazuho Tanaka; Isao Takemura
Archive | 1997
Mikio Kikuchi; Hiroshi Ishikawa; Hideaki Horimoto; Hidetsugu Tsubouchi; Takuya Shitsuta; Hirofumi Sasaki; Motohiro Itotani
Archive | 2017
Hiroshi Shimizu; Yoshikazu Kawano; Shunpei Ishikawa; Yukitaka Uematsu; Toshio Shinohara; Motohiro Itotani; Yoshikazu Haraguchi; Isao Takemura; Atsunori Kaneshige; Yuya Nakai; Norimitsu Hariguchi; Yohei Hayashi; Makoto Matsumoto
Archive | 2016
Yohji Sakurai; Motohiro Itotani; Shigekazu Fujita; Takashi Okamoto; Seiji Sato; Satoshi Matsuda; Chiharu Matsumura; Toshio Shinohara; Kuninori Tai; Tae Fukushima; Naohide Kanemoto
Archive | 2012
Yoshikazu Kawano; Yoshikazu Haraguchi; Hirofumi Sasaki; Yukitaka Uematsu; Hidetsugu Tsubouchi; Hiromi Yata; Hiroshi Shimizu; Kazuho Kohashi; Motohiro Itotani; Kuninori Tai; Isao Takemura; Mikayo Hayashi; Hiroyuki Hashizume; Miki Matsuba; Izuru Nakamura; Xiuhao Chen; Makoto Matsumoto
Archive | 2012
Tae Fukushima; Nobuaki Ito; Motohiro Itotani; Kazumi Kondo; Hideaki Kuroda; Jun Matsubara; Kunio Oshima; Satoshi Shimizu; Hiroshi Yamashita
