Motohiro Nakao
Chiba University
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Featured researches published by Motohiro Nakao.
Pacing and Clinical Electrophysiology | 2003
Akihiko Nogami; Motohiro Nakao; Shoichi Kubota; Aiko Sugiyasu; Hiroshi Doi; Ken Yokoyama; Kazuhiko Yumoto; Toshiyuki Tamaki; Kenichi Kato; Noriyo Hosokawa; Hiroshi Sagai; Hiroyuki Nakamura; Junichi Nitta; Yasuteru Yamauchi; Kazutaka Aonuma
NOGAMI, A., et al.: Enhancement of J–ST‐Segment Elevation by the Glucose and Insulin Test in Brugada Syndrome. The effects of glucose and insulin on J–ST‐segment elevation were evaluated in seven men (mean age 45 ± 10 years) with Brugada syndrome. Six patients had been reanimated from VF and one patient had experienced syncope. The effects of intravenous (1) pilsicainide 50 mg, (2) glucose 50 g, and (3) glucose 50 g plus regular insulin 10 IU on the precordial ECG leads were examined. Pilsicainide significantly enhanced J‐ST elevation in all patients and induced VF in 1 patient. A significant accentuation of the abnormal J‐ST configuration was observed in all patients at a mean of 51 ± 40 minutes after glucose and insulin infusion. Changes in blood glucose and serum potassium concentration were 111 ± 158 mg/dL and −0.30 ± 0.48 mEq/L , respectively. These changes were not directly related to the ECG changes. Glucose infusion without insulin caused a subtle increase in J‐ST elevation. In conclusion, the administration of glucose and insulin safely unmasked or accentuation the J–ST‐segment elevation in Brugada syndrome. Blood glucose and insulin concentrations may be factors modulating the circadian or day‐to‐day ECG variations in this syndrome. (PACE 2003; 26[Pt. II]:332–337)
American Journal of Cardiology | 1999
Nobuaki Shikama; Toshiharu Himi; Katsuya Yoshida; Motohiro Nakao; Masaki Fujiwara; Takashi Tamura; Masato Yamanouchi; Keiichi Nakagawa; Yoichi Kuwabara; Tetsuya Toyozaki; Yoshiaki Masuda
Previous studies in patients with idiopathic dilated cardiomyopathy (IDC) have suggested that myocardial perfusion is impaired and spatially heterogeneous in such cases. Our objective was to identify any association between an abnormality in myocardial perfusion and the prognosis of patients with IDC. We collected data on N-13 ammonia positron emission tomography (PET) studies performed in 26 patients with IDC (9 nonsurvivors, 17 survivors) and in 8 normal control subjects. Regional myocardial blood flow (rMBF) was quantified using N-13 ammonia positron emission tomography and the Simple flow model. The spatial heterogeneity of myocardial perfusion was assessed by calculating the coefficient of variance of rMBF. Mean rMBF of the survivors was significantly lower (0.54 +/- 0.13 ml/min/g) than that of control subjects (0.66 +/- 0.06 ml/min/g) (p = 0.03 vs control), but did not differ significantly between nonsurvivors (0.58 +/- 0.15 ml/min/g) and control subjects. The coefficient of variance of rMBF was significantly higher in nonsurvivors than in either survivors or control subjects (0.24 +/- 0.08 vs 0.15 +/- 0.08, p = 0.007, and 0.16 +/- 0.05, p = 0.03, respectively). The probability of 3-year survival (Kaplan-Meier method) was 33.0% in subjects whose coefficient of variance of rMBF was above the median compared with 90.0% in subjects whose coefficient of variance of rMBF was below the median (p = 0.01). The probability of 3-year survival did not differ among subjects whose mean rMBF was above versus below the median (61.5% vs 62.9%, respectively). The results suggest that the prognosis of patients with IDC is associated with the spatial heterogeneity of myocardial perfusion, not with initial absolute rMBF.
Journal of Arrhythmia | 2011
Motohiro Nakao; Satoru Kobayashi
A 27‐year‐old man presented to our hospital with a 1‐year‐hisory of repeated syncope, which particularly occurred while bathing or on a hot day. The head‐up tilt test did not induce arrhythmia; however, blood pressure decreased by 39 mm Hg without any symptoms. Given that no bradycardia/tachycardia was induced on electrophysiological study and carotid sinus massage, an implantable loop recorder (ILR) was implanted. After 2 months, syncope again occurred during bathing at midnight. Sinus arrest and a maximum ventricular pause of 10.2 s were documented using the ILR. After pacemaker implantation, the patient had not experienced syncope for 14 months.
European Heart Journal | 2001
Masaki Fujiwara; Takashi Tamura; Katsuya Yoshida; Keiichi Nakagawa; Motohiro Nakao; Masato Yamanouchi; Nobuaki Shikama; Toshiharu Himi; Yoshiaki Masuda
Circulation | 2005
Motohiro Nakao; Akihiko Nogami; Aiko Sugiyasu; Shoichi Kubota; Hideki Arima; Shinya Kowase; Atsushi Sakamoto; Kenji Yaginuma; Hajime Aoki; Kazuhiko Yumoto; Toshiyuki Tamaki; Kenichi Kato; Hiroshi Tada; Shigeto Naito
Japanese Circulation Journal-english Edition | 2005
Motohiro Nakao; Akihiko Nogami; Aiko Sugiyasu; Shoichi Kubota; Hideki Arima; Shinya Kowase; Atsushi Sakamoto; Kenji Yaginuma; Hajime Aoki; Kazuhiko Yumoto; Toshiyuki Tamaki; Kenichi Kato; Hiroshi Tada; Shigeto Naito
Japanese Circulation Journal-english Edition | 2001
Motohiro Nakao; Tetsuya Toyozaki; Hiroyasu Nagakawa; Toshiharu Himi; Kenjiro Yamada; Shigeru Watanabe; Yoshiaki Masuda; Takayoshi Asai
Journal of Arrhythmia | 2004
Tatsuya Usui; Akihiko Nogami; Aiko Sugiyasu; Shoichi Kubota; Motohiro Nakao; Hideki Arima; Kenji Yaginuma; Yuji Shiba; Kazuhiko Yumoto; Toshiyuki Tamaki; Kenichi Kato; Masayuki Igawa; Hiroshi Tada; Shigeto Naito
Japanese Circulation Journal-english Edition | 2003
Akihiko Nogami; Aiko Sugiyasu; Tatsuya Usui; Motohiro Nakao; Kenji Yaginuma; Kazuhiko Yumoto; Toshiyuki Tamaki; Shinji Abe; Kenichi Katoh; Hiroshi Tada; Shigeto Naitoh; Koichi Taniguchi; Masayuki Igawa; Kenzo Hirao; Mitsuaki Isobe
Japanese Circulation Journal-english Edition | 2003
Kazuhiko Yumoto; Hiroshi Doi; Kenji Yaginuma; Yuji Shiba; Aiko Sugiyasu; Tatsuya Usui; Motohiro Nakao; Toshiyuki Tamaki; Shinji Abe; Akihiko Nogami; Kenichi Katoh