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Featured researches published by Motoki Endo.


Journal of Cancer Survivorship | 2016

Returning to work after sick leave due to cancer: a 365-day cohort study of Japanese cancer survivors

Motoki Endo; Yasuo Haruyama; Miyako Takahashi; Chihiro Nishiura; Noriko Kojimahara; Naohito Yamaguchi

PurposeMore employees are experiencing a cancer diagnosis during their working-age years, yet there have been no large-scale Japanese studies investigating sick leave due to cancer. We clarified differences in the cumulative partial and full return to work (RTW) rates between different cancer types among Japanese cancer survivors.MethodsData on Japanese employees who experienced an episode of sick leave due to clinically certified cancer diagnosed between 1 January 2000 and 31 December 2011 were obtained from an occupational health register. Subject outcomes within the 365-day period following their initial day of sick leave were utilized for this study. We investigated the cumulative partial/full and full RTW rates by using survival analysis with competing risks and predictors of time to RTW by a Fine-Gray proportional hazard regression model.ResultsOne thousand two hundred seventy-eight subjects (1033 males and 245 females) experienced their first episode of sick leave due to cancer during the 12-year follow-up period. Of the subjects, 47.1 % returned to work full time within 6 months of their initial day of sick leave absence, and 62.3 % by 12 months. The cumulative RTW rate varied significantly by cancer type. There were considerable differences in the range of cumulative full RTW rates between the two categories (“lower full RTW rate” groups (“lung,” “hepatic, pancreatic,” “esophageal,” and “blood” cancer groups) vs. “higher full RTW rate” groups (“gastric,” “intestinal,” “breast,” “female genital,” “male genital,” “urinary”): 6.3 to 14.3 % vs. 11.4 to 28.3 % at 60 days, 10.6 to 22.4 % vs. 27.0 to 50.0 % at 120 days, 21.3 to 34.7 % vs. 38.5 to 65.4 % at 180 days, 34.3 to 42.9 % vs. 66.0 to 79.5 % at 365 days). Additionally, older age may be associated with a longer time to full RTW.ConclusionsMore than half of the subjects returned to work full-time within the 365-day period following their initial day of sick leave, with cumulative RTW rates varying by cancer type. Older employees may require a longer time to full RTW.Implications of Cancer SurvivorsIt is very important for companies (especially small- and medium-sized companies) to establish and improve their RTW support system for cancer survivors, with knowledge that the median time to RTW is expected to be at least a few months.


BMJ Open | 2016

Sickness absence and return to work among Japanese stroke survivors: a 365-day cohort study

Motoki Endo; Toshimi Sairenchi; Noriko Kojimahara; Yasuo Haruyama; Yasuto Sato; Rika Kato; Naohito Yamaguchi

Objectives The objective of this study was to investigate the cumulative return to work (RTW) rate and to clarify the predictors of the time to full-time RTW (full RTW) and resignation among Japanese stroke survivors, within the 365-day period following their initial day of sickness absence due to stroke. Setting This study was based on tertiary prevention of occupational health in large-scaled Japanese companies of various industries. Participants The participants in this study were 382 Japanese workers who experienced an episode of sickness leave due to clinically certified stroke diagnosed between 1 January 2000 and 31 December 2011. Data were obtained from an occupational health register. Participants were followed up for 365 days after the start day of the first sickness absence. The cumulative RTW rates by Kaplan-Meier estimates and predictors for time to full RTW and resignation by Cox regression were calculated. Results A total of 382 employees had their first sickness absence due to stroke during the 12-year follow-up period. The cumulative full RTW rates at 60, 120, 180 and 365 days were 15.1%, 33.6%, 43.5% and 62.4%, respectively. Employees who took sick leave due to cerebral haemorrhage had a longer time to full RTW (HR, 0.50; 95% CI 0.36 to 0.69) than those with cerebral infarction. Older employees (over 50 years of age) demonstrated a shorter time to resignation than younger employees (HR, 3.30; 95% CI 1.17 to 9.33). Manual workers had a longer time to resignation than non-manual workers (HR, 0.24; 95% CI 0.07 to 0.78). Conclusions Cumulative RTW rates depended on the subtype of stroke, and older age was a predictor of resignation.


Journal of Epidemiology | 2017

Personal status of general health checkups and medical expenditure: A large-scale community-based retrospective cohort study

Yasuo Haruyama; Takako Yamazaki; Motoki Endo; Rika Kato; Masanori Nagao; Mitsumasa Umesawa; Toshimi Sairenchi; Gen Kobashi

Background We sought to clarify the association between the personal utilization of general health checkups (GHCs) and medical expenditures (MEs) in a middle-aged Japanese population. Methods A retrospective cohort study was conducted. Subjects were 33,417 residents (15,819 males and 17,598 females) aged 48 years or older in 2010 who were invited to undergo GHCs every year. Official records on GHCs from 2002 to 2007 and MEs from 2008 to 2010 were provided by Soka City, Saitama Prefecture, Japan. The utilization of GHCs was divided into zero times (non-utilizers), 1–3 times (low-frequency utilizers), and 4–6 times (high-frequency utilizers). Tweedie distributions in the generalized linear model were used to analyze the association between MEs and the subgroups of GHC utilization after adjustment for age and sex. Results Of the 33,417 subjects, 20,578 (61.6%) were non-utilizers, 5,777 (17.3%) were low-frequency utilizers, and 7,062 (21.1%) were high-frequency utilizers, based on the attendance to GHCs from 2002 to 2007. Compared with the non-utilizers, the high-frequency utilizers showed significantly higher outpatient MEs (JPY394,700 vs. JPY373,100). The low- and high-frequency utilizers showed significantly lower inpatient MEs (JPY224,000 and JPY181,500 vs. JPY309,300) and total MEs (JPY610,600 and JPY580,700 vs. JPY689,600) than the non-utilizers based on the pooled data from 2008 to 2010. Conclusions This study suggests that the outpatient MEs rise when annual GHCs are increasingly attended (not including the GHC cost), but inpatient and total MEs are lower. To reduce MEs, increasing the rates of attendance at GHCs by the general public may be important.


Industrial Health | 2017

Information exchange using a prescribed form and involvement of occupational health nurses promotes occupational physicians to collaborate with attending physicians for supporting workers with illness in Japan

Go Muto; Rina Ishii Nakamura; Kazuhito Yokoyama; Fumihiko Kitamura; Yuki Omori; Masahiko Saito; Motoki Endo

The maintenance of a balance between work and disease treatment is an important issue in Japan. This study explored factors that affect collaboration between occupational physicians (OPs) and attending physicians (APs). A questionnaire was mailed to 1,102 OPs. The questionnaire assessed the demographic characteristics of OPs; their opinions and behaviors related to collaboration, including the exchange of medical information with APs; and the occupational health service system at their establishments. In total, 275 OPs completed the questionnaire (25.0% response rate). Over 80% of respondents believed OPs should collaborate with APs. After adjusting for company size, collaboration ≥10 times/yr (with regard to both returning to work following sick leave and annual health check-ups for employees) was significantly associated with environmental factors, such as the presence of occupational health nurses (odds ratio (OR): 5.56 and 5.01, respectively, p<0.05) and the use of prescribed forms for information exchange (OR: 4.21 and 3.63, respectively, p<0.05) but not with the demographic characteristics of the OPs (p>0.05). The majority of OPs believed that collaboration with APs is important for supporting workers with illnesses. Support systems including prescribed forms of information exchange and occupational health nurses, play pivotal roles in promoting this collaboration.


Pediatric Pulmonology | 2018

Nocturnal enuresis and sleep disordered breathing in primary school children: Potential implications

Hiroo Wada; Manami Kimura; Tomokazu Tajima; Ryutaro Shirahama; Yohei Suzuki; Y Suzuki; Toshinari Hayashi; Koutatsu Maruyama; Motoki Endo; Naoko Sakamoto; Ai Ikeda; David Gozal; Takeshi Tanigawa

The association between nocturnal enuresis (NE) and sleep disordered breathing (SDB) has been repeatedly reported, but has primarily been focused on clinical cohorts. The purpose of this study, was to assess whether SDB‐related symptoms such as snoring and unrefreshing sleep in the morning are associated with NE in a large‐scale community school‐based survey.


Occupational and Environmental Medicine | 2018

412 Return to work and work sustainability among japanese cancer survivors

Motoki Endo

Introduction In developed countries, the population ages with increasing cancer survival rates, the proportion of working-age cancer survivors is expected to increase. In Japan, it seems that there has been more interest in follow up for employees who returned to work after sick leave due to cancer. The aim of this study is to investigate work sustainability of cancer survivors after RTW and to make ‘Evidence Book for work among cancer’, ‘Guidance for work among cancer survivors, stratified by cancer type’, ‘Card between clinics and companies, stratified by cancer type’. Methods We collected sick leave data of 1278 cancer survivors in a registered Health Data. This is supported by a Health Labour Sciences Research Grant, Japan (Endo-Han). As for ‘Evidence Book’, we collected our previous studies and others. As for ‘Guidance’ and ‘Card’, we made six project team by cancer type (breast cancer, colon cancer, gastric cancer, genitals malignancies, lung cancer etc). Result According to our previous studies, 47.1% returned to work full time within 6 months of their initial day of sick leave absence, and 62.3% by 12 months. The cumulative RTW rate varied significantly by cancer type. Of workers who returned to work after their first episode of leave after cancer, more than 50% continued to work after 5 years in large-scaled companies. There was a steep decrease in work continuance rates during the first year after RTW, with considerable differences according to cancer site. Discussion It is very important for companies (especially small- and medium-sized companies) to establish and improve their RTW support system for employees with cancer.


Nippon Eiseigaku Zasshi (japanese Journal of Hygiene) | 2018

Solutions against Declining Birthrates Confronting Japan’s Aging Society by Supporting Female Workers in Harmonizing Work with Their Health and Social Issues: Fertility, Chronic Illness, and Raising Children

Go Muto; Kazuhito Yokoyama; Motoki Endo

Japan is currently facing serious social problems related to low birth rates and aging. We propose two possible solutions from the perspective of occupational health. First, companies should establish support systems to help working women with pregnancy and childbirth. Such systems would require the cooperation and understanding of coworkers, including men, and the introduction of flexible work schedules that are also designed to allow workers to care for family members with disabilities. Additionally, with regard to the protection and promotion of the fertility of working women, occupational health staff members should provide education to working women regarding appropriate lifestyle choices in areas such as diet, prevention of work-related health problems, and mental health before and after childbirth. Moreover, workers undergoing assisted reproductive technology procedures should be supported as they experience physical, mental, and economic burdens associated with this process. Second, companies should guarantee the right of workers to take a sick leave and then return to work so they can balance work and the need to treat chronic conditions. Occupational staff members should follow up employees who return to work, by offering, for example, mental health care to cancer survivors. They should also play important roles in preventing the exacerbation of disease and empowering workers to continue their visits to medical institutions. Collaborative study bridges between companies and medical institutions are necessary for the promotion of these harmonization schemes.


Industrial Health | 2018

A cooperative support model for cancer therapy and employment balance: from focus-group interviews of health and business professionals

Miho Takahashi; Chika Uetake; Naoko Nakayama; Akiko Eura; Natsumi Yamaguchi; Yui Kameda; Go Muto; Motoki Endo; Kayo Kawamata; Tomoko Fujii; Hiroyuki Oka; Ko Matsudaira

This study aimed to obtain a comprehensive collection of ideas and opinions from the perspective of various professionals and support providers for cancer treatment and employment balance. We performed a focus group interview, and a model diagram was created using categories created via classification of important items. The focus group interview revealed six strategies aligned with seven issues concerning the support needed to balance cancer treatment and employment. These strategies suggested the importance of not only the way of directly connecting among several specialists but also the presence and the role of the coordinators with their own specialties. Workers with cancer need supportive advices after their initial diagnosis, when returning to work, and after returning to work. After returning to work, a number of problems resulted from the lack of advice at the time of diagnosis or when returning to work. These results emphasized the necessity for the development of early comprehensive system for integrated collaboration between medical institutions, workplaces and other occupational health institutions. The results suggest that a multi-profession collaboration model is necessary to support cancer patients staying at work, which includes the cooperation between medical institutions and their counterparts from occupational health and the patients’ employers.


Industrial Health | 2018

Durations of first and second periods of depression-induced sick leave among Japanese employees: the Japan sickness absence and return to work (J-SAR) study

Motoki Endo; Yasuo Haruyama; Kiyomi Mitsui; Go Muto; Chihiro Nishiura; Keisuke Kuwahara; Hiroo Wada; Takashi Tanigawa

This study aimed to clarify the difference between the durations of first and second periods of depression-induced sick leave and to identify predictors of a prolonged second period of depression-induced sick leave. Among Japanese employees who were registered in the Japan sickness absence and return to work (J-SAR) study, the subjects were those employees who returned to work after an initial period of depression-induced sick leave (F3; ICD-10, based on a psychiatrist’s certificate), and returned to work after a second period of depression-induced sick leave. The subjects’ second periods of sick leave (mean: 156.9 d) were longer than their first periods of sick leave (107.3 d) (Wilcoxon test, p=0.007). In the logistic regression analysis (Table 2), “longer duration of the first period of sick leave” (Odds ratio: 3.258, 95%CI: 1.780–5.963, p<0.001) was identified as a significant predictor of a longer recurrent period of sick leave. Individuals who experience a long initial period of depression-induced sick leave should be supported carefully by occupational health professionals after they RTW.


Industrial Health | 2018

Harmonizing work with the treatment and prevention of sleep disordered breathing in commercial motor vehicle drivers: implications for health and productivity management

Hiroo Wada; Manami Kimura; Ryutaro Shirahama; Tomokazu Tajima; Koutatsu Maruayama; Motoki Endo; Ai Ikeda; Takeshi Tanigawa

The desastrous traffic accidents to date have provided the relevance for promotion of harmonization of work with treatment and prevention of sleep disordered breathing (SDB) in transport sectors. SDB is highly prevalent in commercial motor vehicle (CMV) drivers and is one cause of cognitive impairment and consequent traffic accidents, potentially costing billions and leading to many deaths. Various screening, diagnostic, and therapeutic approaches, some well established, are explored in this paper. Although drivers with SDB need to be appropriately diagnosed and treated, some are reluctant to continue their treatment or never submit to screening because of a lack of information. Thus, CMV drivers need to be well informed and screened, in addition to being encouraged to continue the treatment. The harmonization of work with treatment and prevention aids these objectives, providing benefits not only for individual health but also for transport companies, and further being an essential step towards uptake of “health and productivity management” in the transport sectors.

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Yasuo Haruyama

Dokkyo Medical University

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Naohito Yamaguchi

Tokyo University of Agriculture

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