Motokuni Mori

The bile acid binding and hypocholesterolemic activity of anion—exchange resins bearing the imidazolium salt group

Abstract A new anion—exchange resin bearing imidazolium pendant groups on a polystyrene copolymer skeleton was synthesized. This resin is a white odorless powder and the bile acid binding activities in vitro were much more potent than those of cholestyramine. The ion- exchange equilibrium coefficient K phosphoric acid ion − bile acid ion − was 271, compared to that of cholestyramine which was 32. The hypocholesterolemic activity of this resin in cholesterol-fed rabbits proved to be 1.5-fold more potent than that of cholestyramine. Thus, the effective reduction of plasma cholesterol may be achieved with significantly lower doses of this resin.

Vasodilation produced by prostacyclin (PGI2) and 9(0)-thiaprostacyclin (PGI2-S) in the caninen femoral circulation

The action of 9(0)-thiaprostacyclin (PGI2-S) was compared with that of prostacyclin (PGI2) and papaverine in the femoral circulation of dogs. PGI2-S, injected into the dog femoral artery in a dose of 0.1 microgram or higher, produced marked vasodilation in the femoral artery without any change in blood pressure. The potentcy of PGI2-S was one tenth that of PGI2, and was a hundred times that of papaverine. The stability of PGI2-S in neutral solution was forty times that of PGI2.