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Featured researches published by Mougnyan Cox.


American Journal of Neuroradiology | 2017

Enhancing the Radiologist-Patient Relationship through Improved Communication: A Quantitative Readability Analysis in Spine Radiology

David R. Hansberry; A.L. Donovan; Arpan V. Prabhu; Neeraj Agarwal; Mougnyan Cox; Adam E. Flanders

BACKGROUND AND PURPOSE: More than 75 million Americans have less than adequate health literacy skills according to the National Center for Education Statistics. Readability scores are used as a measure of how well populations read and understand patient education materials. The purpose of this study was to assess the readability of Web sites dedicated to patient education for radiologic spine imaging and interventions. MATERIALS AND METHODS: Eleven search terms relevant to radiologic spine imaging were searched on the public Internet, and the top 10 links for each term were collected and analyzed to determine readability scores by using 10 well-validated quantitative readability assessments from patient-centered education Web sites. The search terms included the following: x-ray spine, CT spine, MR imaging spine, lumbar puncture, kyphoplasty, vertebroplasty, discogram, myelogram, cervical spine, thoracic spine, and lumbar spine. RESULTS: Collectively, the 110 articles were written at an 11.3 grade level (grade range, 7.1–16.9). None of the articles were written at the American Medical Association and National Institutes of Health recommended 3rd-to-7th grade reading levels. The vertebroplasty articles were written at a statistically significant (P < .05) more advanced level than the articles for x-ray spine, CT spine, and MR imaging spine. CONCLUSIONS: Increasing use of the Internet to obtain health information has made it imperative that on-line patient education be written for easy comprehension by the average American. However, given the discordance between readability scores of the articles and the American Medical Association and National Institutes of Health recommended guidelines, it is likely that many patients do not fully benefit from these resources.


Pediatric Radiology | 2016

Magnetic resonance imaging of acquired disorders of the pediatric female pelvis other than neoplasm

Mougnyan Cox; Sharon W. Gould; Daniel J. Podberesky; Monica Epelman

Transabdominal US remains the primary screening imaging modality of the pediatric female pelvis. However, MRI has become an invaluable adjunct to US in recent years. MRI offers superb soft-tissue contrast resolution that allows for detailed evaluation, particularly of the ovaries and their associated pathology. MRI can yield diagnostic information that is similar to or even better than that of US, especially in nonsexually active girls in whom transvaginal US would be contraindicated. MRI is generally a second-line examination and is preferred over CT because it does not involve the use of ionizing radiation. MRI might be underutilized in this population, particularly in differentiating surgical from nonsurgical conditions. This article reviews the relevant anatomy and discusses imaging of acquired conditions that involve the pediatric female genital tract, illustrating associated pathology with case examples.


Academic Radiology | 2016

CT-guided Cervical Bone Biopsy in 43 Patients: Diagnostic Yield and Safety at Two Large Tertiary Care Hospitals

Mougnyan Cox; Bryan Pukenas; Michael Poplawski; Aaron Bress; Diane M. Deely; Adam E. Flanders

RATIONALE AND OBJECTIVES The cervical spine is a high-risk area for percutaneous biopsy compared to the thoracic and lumbar regions. Biopsy of the cervical spine is less commonly undertaken, and previously published series on diagnostic yield and safety of cervical spine biopsy have been limited to 12 patients or less. The purpose of our study is to further define the diagnostic yield of computed tomography (CT)-guided biopsy for bony lesions identified in the cervical spine, by combining data from two large tertiary care referral centers. METHODS A retrospective review of an imaging database was performed to identify all percutaneous CT-guided biopsies of the cervical spine performed at two tertiary care hospitals from 2010 to 2015. Core biopsies were obtained whenever possible and supplemented with fine-needle aspiration in some cases. Histopathologic results of the biopsy were recorded, as were changes in subsequent management, need for repeat biopsy, and complications. RESULTS Forty-three patients underwent CT-guided biopsy of the cervical spine. Sufficient tissue for histopathologic analysis was obtained in 41 out of 43 cases, for a yield of 95%. One case was false-negative and one was deemed insufficient by the pathologist for diagnostic purposes; in both of these cases, only a fine-needle aspiration was obtained. There were no immediate or delayed complications. CONCLUSIONS Percutaneous biopsy of the cervical spine is a safe and high-yield method of obtaining a tissue diagnosis when performed under image guidance with CT.


Emergency Radiology | 2018

Quantitative analysis of the level of readability of online emergency radiology-based patient education resources

David R. Hansberry; Michael D’Angelo; Michael D. White; Arpan V. Prabhu; Mougnyan Cox; Nitin Agarwal; Sandeep Deshmukh

PurposeThe vast amount of information found on the internet, combined with its accessibility, makes it a widely utilized resource for Americans to find information pertaining to medical information. The field of radiology is no exception. In this paper, we assess the readability level of websites pertaining specifically to emergency radiology.MethodsUsing Google, 23 terms were searched, and the top 10 results were recorded. Each link was evaluated for its readability level using a set of ten reputable readability scales. The search terms included the following: abdominal ultrasound, abdominal aortic aneurysm, aortic dissection, appendicitis, cord compression, CT abdomen, cholecystitis, CT chest, diverticulitis, ectopic pregnancy, epidural hematoma, dural venous thrombosis, head CT, MRI brain, MR angiography, MRI spine, ovarian torsion, pancreatitis, pelvic ultrasound, pneumoperitoneum, pulmonary embolism, subarachnoid hemorrhage, and subdural hematoma. Any content that was not written for patients was excluded.ResultsThe 230 articles that were assessed were written, on average, at a 12.1 grade level. Only 2 of the 230 articles (1%) were written at the third to seventh grade recommended reading level set forth by the National Institutes of Health (NIH) and American Medical Association (AMA). Fifty-two percent of the 230 articles were written so as to require a minimum of a high school education (at least a 12th grade level). Additionally, 17 of the 230 articles (7.3%) were written at a level that exceeded an undergraduate education (at least a 16th grade level).ConclusionsThe majority of websites with emergency radiology-related patient education materials are not adhering to the NIH and AMA’s recommended reading levels, and it is likely that the average reader is not benefiting fully from these information outlets. With the link between health literacy and poor health outcomes, it is important to address the online content in this area of radiology, allowing for patient to more fully benefit from their online searches.


British Journal of Radiology | 2016

Imaging of ocular melanoma metastasis

Rashmi Balasubramanya; Santosh Selvarajan; Mougnyan Cox; Ganesh Joshi; Sandeep Deshmukh; D. G. Mitchell; Patrick O'Kane

Ocular melanoma is the most common adult primary intraocular tumour. Although <1% of patients have metastatic disease at the time of initial diagnosis, most will develop metastasis at varying lengths of time. Metastasis surveillance is therefore critical in the follow-up of patients with ocular melanoma. Liver is the most common site of metastasis and prognosis is based on the treatment of liver metastasis. Hence, imaging of liver metastasis is vital. MRI is the most specific modality for imaging liver metastasis and is at least as sensitive as CT. Extrahepatic metastasis such as retroperitoneal nodules and bone metastases are also better evaluated on MRI. Gadolinium-based contrast agents are extremely helpful for detecting liver lesions. In particular, newer hepatobiliary contrast agents which offer an additional hepatobiliary phase of excretion help in the detection of even tiny liver metastases. Diffusion-weighted imaging is helpful when an i.v. contrast cannot be administered. Treated lesions are also better evaluated with MRI. CT is useful for evaluating lung nodules, large liver metastasis or in patients in whom MRI is medically contraindicated. The disadvantage lies in its inability to detect small liver metastasis and the radiation dose involved. The lesions treated with iodized oil as part of chemoembolization procedures can be followed on CT. Ultrasound can be used only for detecting hepatic metastases. However, it is heavily operator dependent, technically challenging and time consuming especially in patients who are large. Extrahepatic metastasis cannot be seen on ultrasound. Its utility is primarily for the biopsy of liver lesions. Positron emission tomography (PET)-CT can detect lung nodules and large liver lesions but is insensitive to small liver lesions. Moreover, the high radiation dose is a major disadvantage.


Emergency Radiology | 2015

Incidental left atrial and ventricular thrombi on routine CT: outcome and influence on subsequent management at an urban tertiary care referral center

Mougnyan Cox; Rashmi Balasubramanya; Angela Hou; Sandeep Deshmukh; Laurence Needleman

Incidental left-sided cardiac thrombi are occasionally encountered on CT. This study examined clinical findings and outcome in patients with incidental cardiac thrombi on CT. Our image database was reviewed for incidental left-sided cardiac thrombi on CT. These patients’ charts were retrospectively reviewed. Thirty-five patients had incidental left-sided cardiac thrombi on CT, 26 of which were ventricular and 9 atrial. Thirty-two thrombi were unknown prior to the CT, and the radiologist interpretation triggered echocardiography or anticoagulation in most cases. Embolic complications occurred in 14 patients, 4 of which were fatal. Twelve patients had concomitant cancer, 6 of which were newly discovered. Incidental left-sided cardiac thrombi on CT appeared to confer substantial morbidity and mortality in our study. In many cases, the cardiac thrombi were new and led to changes in management. A high rate of malignancy was also noted, which may be related to the hypercoagulable state of malignancy.


Emergency Radiology | 2018

Contrast-enhanced or noncontrast CT for renal colic: utilizing urinalysis and patient history of urolithiasis to decide

Vishal Desai; Mougnyan Cox; Sandeep Deshmukh; Christopher G. Roth

PurposeIn the emergency setting, flank pain commonly leads to a noncontrast CT despite a significant percentage of patients having alternative diagnoses, often difficult to characterize without contrast. We investigated the combined utility of urinalysis and history of urolithiasis in identifying patients who are unlikely to have urolithiasis and may benefit from a contrast-enhanced study.MethodsRetrospective review of 350 patients from May 2013 to May 2016 was performed for patients in the emergency department with renal colic that underwent noncontrast CT and urinalysis testing.ResultsUrolithiasis was present in 282 of the 350 patients reviewed (81%), of which 175 (62%) had an obstructing calculus. RBC-positive urinalysis was present in 231 patients with calculi on CT (sensitivity 82%). Patient history of urolithiasis plus urinalysis had a sensitivity of 94% for detecting calculi. Thirty-five patients (10%) had alternative diagnoses, 33 of which were in patients without obstructing calculi. Sixty-seven patients underwent noncontrast CT despite no history of urolithiasis and a negative urinalysis, 10 of which (15%) had alternative diagnoses. Only three cases in this subset (4%) had nonobstructing 1–2-mm calculi, potentially missed with contrast. In this subset, the projected proportion of optimally characterized cases with intravenous contrast is 96%, compared to 85% without contrast (p = .03).DiscussionGiven the high combined sensitivity of urinalysis and patient history (94%), this simple analysis can confidently direct clinicians to a contrast-enhanced CT in “rule-out” cases of flank pain in patients with a negative history and negative urinalysis, particularly given that 15% of these patients had alternative diagnoses.


Internal and Emergency Medicine | 2017

Precipitous neurologic decline following intraventricular rupture of a cerebral abscess: classic imaging findings in ventriculitis and pyocephalus

Mougnyan Cox; Manisha Patel; Vishal Kukkar; Pranshu Sharma

An 80-year-old man was admitted to an outside hospital for a headache, fever, and altered mental status. His admission to neurologic examination was notable for right eye deviation and right gaze preference. Neuroimaging was performed, and showed a ring-enhancing mass with central restricted diffusion in the right occipital lobe consistent with an abscess. During his admission, he became obtunded, and repeat imaging was performed. Repeat contrast-enhanced magnetic resonance imaging showed interval rupture of the right occipital lobe abscess into the adjacent lateral ventricle, with evidence of pyocephalus and ventriculitis. He was transferred to our facility for neurosurgical debridement of his abscess. Pyogenic ventriculitis is a life-threatening complication of cerebral abscesses caused by rupture and decompression of an abscess into the ventricles [1, 2]. Due to differences in blood supply, the wall of a cerebral abscess is usually thinner at its medial margin facing the ventricles, which predisposes rupture at this site. Signs of Intraventricular rupture of an abscess include a direct connection between the abscess and the ventricle, pyogenic debris within the ventricles, and abnormal thickening shown by increased enhancement of the ventricular wall [3]. Diffusion-weighted images are especially helpful, as viscous, pyogenic material is often diffusion-restricting, and will be bright on diffusion-weighted imaging. Delays in detecting ventriculitis can result in death or severe neurologic disability, even after successful treatment of infection [4]. Familiarity with the common imaging appearance of pyogenic ventriculitis can facilitate earlier diagnosis and treatment of this devastating condition, and potentially improve outcomes.


Clinical Imaging | 2017

Thoracic spinal osteochondroma: A rare presentation of spinal cord compression

David R. Hansberry; Raghav Gupta; Arpan V. Prabhu; Nitin Agarwal; Mougnyan Cox; Upasana Joneja; Mark T. Curtis; James S. Harrop; Adam E. Flanders

Osteochondromas are the most common benign bone tumor typically seen in the appendicular skeleton and are rarely found in the spine. We present a case of an osteochondroma of the spine presenting with spinal cord compression. 27-year-old male presented with lower extremity weakness and paresthesia, decreased lower extremity sensation, and decreased proprioception. MRI showed a heterogeneous mass with minimal peripheral enhancement and without restricted diffusion. CT demonstrated a calcified mass extending from the left facet joint of T11-T12 with medial extension, resulting in severe central canal stenosis and cord compression. The patient underwent surgical resection with pathology demonstrating an osteochondroma.


World Neurosurgery | 2018

Muslin Granuloma Mimicking Parenchymal Hematoma in Patient with Seizures 30 Years After Aneurysm Wrapping

Mougnyan Cox; Neda Sedora-Roman; Omar Choudhri

Muslin foreign body granulomas are a known complication of muslin aneurysm wrapping and have been associated with vision loss from optochiasmatic arachnoiditis. Muslin granulomas have also been confused with abscesses due to surrounding inflammatory changes. In this clinical image, we present a unique case of a muslin granuloma mimicking an intraparenchymal hematoma.

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Sandeep Deshmukh

Thomas Jefferson University

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Adam E. Flanders

Thomas Jefferson University Hospital

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Manisha Patel

Thomas Jefferson University

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Robert W. Hurst

University of Pennsylvania

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David R. Hansberry

Thomas Jefferson University

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Santosh Selvarajan

Thomas Jefferson University

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Bryan Pukenas

University of Pennsylvania

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David Kung

Hospital of the University of Pennsylvania

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