Mourad Daoubi

Two novel steroids from Euphorbia officinarum latex.

Two novel steroids, 3β,7α-dihydroxy-4α,14α-dimethyl-5α-cholest-8-en-11-one (2) and 3β,7β-dihydroxy-4α,14α-dimethyl-5α-cholest-8-en-11-one (3) were isolated from the latex of Euphorbia officinarum. Their structures were established on the basis of NMR and MS studies.

Hemisynthesis of New Triterpene Derivatives using Oxidation by CrO3 and NaIO4‐(RuCl3, 3H2O)

Abstract Oxidation of triterpenes resulting from E. resinifera, E. officinarum, and their derivatives, using chromic anhydride (CrO3) and the system NaIO4‐(RuCl3,3H2O), gives carbonyl triterpenic compounds with high chemioselectivity.

3β-Acetoxy-elemo-lanost-8-en-24-one

The sodium periodate is prepared in situ with a equimolecular quantity of soda NaOH (0.5g; 12.50 mmol) and periodic acid H5IO6 (2.85g; 12.50 mmol), the mixture is stirred at 0°C. After 15 min, 5 ml of CCl4, 5 ml of H3CCN and 93.03mg (0.12mmol) of ruthenium trichloride1,2 were added.[...]

3β-Acétoxy nor-31-lanostène-7,11-dione

The structure of the title compound, C31H48O4, has been established by X-ray crystallographic study. The molecule exhibits an extended conformation.

ELAC (3,12-di-O-acetyl-8-O-tigloilingol), a plant-derived lathyrane diterpene induces subventricular zone neural progenitor cell proliferation through protein kinase C beta activation.

Pharmacological strategies aimed to facilitate neuronal renewal in the adult brain, by promoting endogenous neurogenesis, constitute promising therapeutic options for pathological or traumatic brain lesions. We have previously shown that non‐tumour‐promoting PKC‐activating compounds (12‐deoxyphorbols) promote adult neural progenitor cell (NPC) proliferation in vitro and in vivo, enhancing the endogenous neurogenic response of the brain to a traumatic injury. Here, we show for the first time that a diterpene with a lathyrane skeleton can also activate PKC and promote NPC proliferation.

3β-Tosyloxy-elemo-lanost-8-en-24-one

The sodium periodate is prepared in situ with equimolecular quantity of soda NaOH (0.5g; 12.50 mmol) and periodic acid H5IO6 (2.85g; 12.50 mmol), the mixture is stirred at 0°C.[...]