Mozammel Hoque

Frequency of insulin resistance in nondiabetic adult Bangladeshi individuals of different obesity phenotypes

Insulin resistance (IR) is the corner stone of metabolic obesity. This cross-sectional analytical study was aimed to find out the frequency of IR in non-diabetic adult individuals of different obesity phenotypes that would help to implement preventive measures to avoid the cardiometabolic catastrophes. METHODS Total 955 nondiabetic adult individuals were selected and categorized into six metabolic phenotypes by metabolic syndrome criteria in each BMI group (18.5-24.9-normal weight, 25-29.9-overweight, ≥30-obese). From them, metabolically obese normal weight, metabolically obese overweight, metabolically healthy obese and metabolically unhealthy obese were selected as Obesity phenotypes (N = 616). RESULTS The frequency of IR was found to be very high (60.2%) in total nondiabetic adult obese individuals (N = 616). Highest frequency of IR was found in MUO phenotype (76.3%), lowest frequency of IR was found in MONW phenotype (37.1%) and frequency of IR in MOOW and MHO phenotypes found to be identical but significantly (p < 0.0001) less than MUO and significantly (p < 0.0001) more than MONW phenotype. Among the obesity phenotypes, females were more insulin resistant than males (67.5% vs 48.1% respectively, p < 0.05). Frequency of IR found significantly (p < 0.05) more in female than male in all obesity phenotypes except in MUO phenotype where males found to show significantly (p < 0.05) higher frequency than females. Frequency of IR was significantly higher in younger (20-39 yrs) age group than 40-60 yrs age group (63.2% vs 53.5% respectively, p < 0.05). CONCLUSION IR is alarmingly high (60.2%) in nondiabetic adult obese individuals. Among different obesity phenotypes, it is highest (76.3%) in MUO and lowest (37.1%) in MONW.

Injection Sclerotherapy with 5% Phenol in Almond Oil in the Treatment of Rectal Prolapse in Children: Our Experience

Background: Rectal prolapse is a relatively common condition in children. A wide variety of sclerosing agents have been used in the treatment of rectal prolapse in children. We have used 5 % phenol in almond oil in the treatment of rectal prolapse in our children. The aim of this study was to find out the outcome of injection sclerotherapy with 5% phenol in almond oil in the treatment of rectal prolapse in children. Methods: From May 2009 to December 2016 a total of 186 patients with rectal prolapse were treated by injection sclerotherapy with 5% phenol in almond oil. Of which males were 112 and females 74. Age ranged from 1.5 years to 7 years. Initial management included assessment and correction of predisposing factors. If the rectal prolapse persisted or if the prolapse required repeated reduction, injection sclerotherapy was performed. Number of injections, recurrences, and complications were reviewed. Results: Out of 186 patients recurrence occurred in 12 patients, cured after second injection in 10 patients and 2 children needs Thiersch’s stitch. Excessive oozing at the injection site was in 5 patients. Conclusion: Injection sclerotherapy with 5% phenol in almond oil is simple, safe and effective treatment of recurrent rectal prolapse after failure to conservative measures. Chatt Maa Shi Hosp Med Coll J; Vol.16 (1); Jan 2017; Page 19-21