Muhammad Rashedul Islam

THROMBOLYTIC AND MEMBRANE STABILIZING PROPERTIES OF METHANOLIC EXTRACTS OF AVICENNIA MARINA LEAVES & BARKS

The present study was commenced to judge ethnomedicinal worth of the plant. We tried to analyze in vitro thrombolytic and membrane stabilising activities of methanolic extracts of Avicennia marina . Crude methanolic extracts of A. marina leaves & barks at numerous conc. were used for in vitro thrombolytic and membrane stabilising activities. Just in case of thrombolytic study, it absolutely was dose dependently accumulated , wherever 10 mg/ml concentration most importantly showed 13.22% lysis of clot (p< 0 .001) by in vitro clot lysis assay technique . Streptok inase was used as standard & water was treated as negative management . Crude methanolic extracts of A. marina dose dependently increased in membrane stabilising study, whereas 10 mg/ml concentration most importantly showed 10.11% & 22.23% inhibition of hae molysis severally by both hypotonic solution and heat induced haemolysis of RBC membrane. Acetyl salicylic acid was used as standard in membrane stabilising study.

Recent Prescribing Patterns of Cardiac Physicians in Metropolitan Dhaka City, Bangladesh

A large number of people in Bangladesh suffer from many cardiovascular diseases (CVDs). Therefore, cardiovascular drugs are one of the major classes of drugs prescribed in Bangladesh. The study of prescribing patterns seeks to monitor, evaluate and suggest modifications in clinicians’ prescribing habits to make medical care more rational. This study was mainly focused on the recent trends of prescribing patterns of oral cardiovascular drugs in Dhaka city. It was a questionnaire-based direct interview type of descriptive study, conducted in the cardiology departments of eight most renowned hospitals of Dhaka, during the study period of February 2017 to April 2017. Most patients in the disease states belonged to the older age group of 50-60 years. More male patients were found in the cardiology departments than the female patients. Hypertension was the most prevalent diseases (86.67%) followed by angina (75.00%) and myocardial infarction (53.33%). Most commonly prescribed antihypertensive medication was angiotensin-II receptor blocker (ARB, 55.00%) and individually losartan (61.67%), followed by angiotensin-converting enzyme inhibitor (ACEI, 25.00%) and only ramipril (90.00%). Amlodipine was the first choice of every respondent when prescribing a calcium-channel blocker (CCB). In case of combination products, amlodipine plus atenolol was found to be the most preferred (65%) medication, followed by hydrochlorothiazide plus losartan (40%).