Muhammet Sayan

Protective Effects of Alpha-Lipoic Acid on Methotrexate-Induced Oxidative Lung Injury in Rats

ABSTRACT Objective: Oxidative stress is one of the major causes of methotrexate induced lung injury (MILI). Alpha-lipoic acid (ALA), which occurs naturally in human food, has antioxidative and anti-inflammatory activities. The aim of this study was to research the potential protective role of ALA on MILI in rats. Methods: Twenty one rats were randomly subdivided into three groups: control (group I), methotrexate (MTX) treated (group II), and MTX+ALA treated (group III). Lung injury was performed with a single dose of MTX (20 mg/kg) to groups 2 and 3. On the sixth day, animals in all groups were sacrificed by decapitation and lung tissue and blood samples were removed for histological examination and also measurement the levels of interleukin-1-beta (IL-1β), malondialdehyde (MDA), glutathione (GSH), tumour necrosis factor-alpha (TNF-α), myeloperoxidase (MPO), and sodium potassium-adenosine triphosphatase (Na+/K+ATPase). Results: In MTX group tissue GSH, Na+/K+ATPase activities were lower, tissue MDA, MPO and plasma IL-1?, TNF-? were significantly higher than the other groups. Histopathological examination showed that lung injury was less severe in group 2 according to group 3. Conclusions: Oxidative damage of MTX in rat lung is partially reduced when combined with ALA.

Mediastinal neurothekeoma: A rare tumor

Neurothekeoma, also known as nerve sheath myxoma, is a benign nerve sheath tumor that usually arises in the cutaneous nerves of the head, neck, or upper extremities. Extracutaneous placement is very rare. Mediastinal neurothekeoma has not previously been reported in the English literature. A 30-year-old woman was admitted to our clinic with back pain. A smooth-edged mass found in her paravertebral region, and a neurogenic tumor was suspected. The tumor was completely excised. Final pathology revealed it to be a mediastinal neurothekeoma.

Non-traumatic tension gastrothorax in a young lady

Tension gastrothorax is a very rare but potentially fatal clinical condition in which the stomach that herniates through a diaphragmatic defect into the thorax is massively distended by trapped air. It leads to severe symptoms due to the compression of the lung and mediastinum. A 27-year-old female, who had no prior trauma history, applied to the emergency service with the complaint of respiratory disorder, and was consulted by the department of thoracic surgery. Thorax CT revealed presence of gastrothorax in the left hemithorax. Thus, the patient went into cardiopulmonary arrest and was resuscitated. Emergency thoracotomy was performed, abdominal organs were reduced and diaphragmatic defect was repaired. She was discharged on the fifth postoperative day without any complications.

Pulmonary mucormycosis mimicking an endobronchial mass

Mucormycosis is an opportunistic fungal infection that can infect different regions of the body. This entity may present in rhinocerebral, pulmonary, cutaneous, and disseminated forms. Although pulmonary mucormycosis is usually seen as an invasive parenchymal consolidation or cavitation, it may rarely present as an endobronchial mass. We describe a case of endobronchial mucormycosis in which the fungal mass was completely removed via rigid bronchoscopy before medical therapy.

A Case of Pulmonary Alveolar Microlithiasis Diagnosed by Transbronchial Biopsy

Pulmonary alveolar microlithiasis is a rare infiltrative pulmonary disease, in which intraalveolar accumulation of small stones (microliths) consisting of calcium phosphatite occurs. It is an autosomal recessive disorder. The disease occurs as a result of the disruption of type IIb sodium phosphate cotransporter in type II alveolar cells after the mutation of SLC34A2. Majority of patients are diagnosed between age 20 and 40. Here, we present a case of alveolar microlithiasis that was diagnosed with transbronchial biopsy.

Upregulated mrna expression of mtor in surgically resected early stage non-small cell lung carcinoma: a potential molecular targeted therapy

Background: Non-small cell lung cancer (NSCLC) comprises about 85% of all lung cancers. Although many attempts for early detection and treatment, prognosis of NSCLC is still poor. In recent years the pathways and the genes that play role in lung cancer development were researched widely. PI3K/AKT/MTOR which is thought to be efficacious in the development of many cancer which controls the expression of many genes playing an important role in cell proliferation, metastasis, resistance to apoptosis and angiogenesis. Also the increase in CCND1 expression was shown in several cancer types. The aim of this study is to search the mRNA expression profile of AKT, MTOR and CCND1 genes which has been thought to play role in NSCLC development, and their expression in different pathological stages and histological types of the disease. Materials and Methods: Forty-four NSCLC patients who didn’t get neoadjuvant therapy were included in this study. The samples from tumor and matched normal lung tissue were obtained from resection specimens (lobectomy or pneumonectomy). Total cellular RNA was isolated from the samples. The mRNA expression levels of AKT1, mTOR and CCND1 genes were measured by quantitative real-time polymerase chain reaction (qPCR). Results: Our findings revealed a statistically significant increase of mTOR expression on mRNA levels (P < 0.05). Although AKT and CCND1 expression slightly increased in malign tissues, these changes in the expression were not significant (P > 0.05). The mRNA expression of mTOR was also upregulated and it was statistically significant for early stage disease and adenocarcinoma subtype (P < 0.05). Conclusions: Inhibition of mTOR gene expression at mRNA level might be potential target for future treatment strategies of NSCLC.

Chest wall deformities and coincidence of additional anomalies, screening results of the 25.000 Turkish children with the review of the literature

Background: The main subtypes of chest wall deformities are pectus excavatum (PE) and pectus carinatum (PC). Although these are not life threatening diseases, some functional or physico-social disabilities due to the abnormal chest wall structure require treatment. The main stem of the treatment is surgical correction. Since the beginning of the 20 th century various surgical techniques were introduced. In the last few decades some minimally invasive surgical techniques were also described. In the English literature many reports suggest that the vast majority of these abnormalities are PE. But in most of the reports patient groups consist of hospital admissions. The real frequency of this group of disease is controversial. Materials and Methods: In this report, a wide field study was designed to find the real frequency of the chest wall diseases. Total of 25117 children between 6-11 years of age were visited in the elementary schools of Kahramanmaras. The team members were a thoracic surgeon, a pulmonologist and a pediatrician. Results: A careful physical examination revealed that a total of 255 patients had different degrees of chest wall deformity. We found that PC (90.58%) was the most frequent type of deformity in contrast with the previous reports suggesting PE as the most frequent type. In our results only 5.49% of the patients had PE and 3.93% of the patients had mixed type PE+PC. The most frequent ECG abnormality seen in 49 cases (19% of cases with deformity) was a negative T wave on V1 derivation and a biphasic T wave configuration on V1-V2 derivations. 8 patients (3.13%) had concomitant scoliosis and 6 patients (%2.35) had different degrees of cardiomegaly. Conclusions: The real frequency of chest wall deformities is an enigma. When PE patients themselves or their family notice the abnormality, they may consider it as a big health problem and admit to a healthcare unit. But in contrast, PC patients mostly do not care about this disorder until adolescence, so admission rate is less then PE. We suggest that the real frequency of the chest wall deformities may be found only by widespread field studies. Moreover, we found more accompanying cardiac disorders in PC group, and this type of screening may allow early diagnosis of some cardiac diseases.

One-Stage Operation for Hydatid Disease of Right Lung and Liver; Analysis of the 21 Patients

1 İlknur Aytekin1, Kerim Tülüce2, Şevki Mustafa Demiröz3, Muhammet Sayan4, İsmail Cüneyt Kurul5, Sedat Demircan5 1Ordu Devlet Hastanesi, Göğüs Cerrahisi Bölümü, Ordu, 2Rize Devlet Hastanesi Göğüs Cerrahisi Bölümü, Rize, 3Malatya Devlet Hastanesi, Göğüs Cerrahisi Bölümü, Malatya, 4Aksaray Devlet Hastanesi, Göğüs Cerrahisi Bölümü, Aksaray, 5Gazi Üniversitesi Tıp Fakültesi, Göğüs Cerrahisi Bölümü, Ankara, Türkiye Eş Zamanlı Akciğer ve Karaciğer Hidatik Kist Cerrahisi / Simultaneous Lung and Liver Hydatid Cysts Surgery One-Stage Operation for Hydatid Disease of Right Lung and Liver; Analysis of the 21 Patients

Surgical Treatment of the Lung Hydatid Cysts; Analysis of the 73 Patients

1 Ilknur Aytekin1, Kerim Tuluce2, Mustafa Demiroz3, Muhammet Sayan4, Ismail Cuneyt Kurul5, Sedat Demircan5, Abdullah Irfan Tastepe5 1Ordu Devlet Hastanesi, Gogus Cerrahisi Bolumu, Ordu, 2Rize Devlet Hastanesi Gogus Cerrahisi Bolumu, Rize, 3Malatya Devlet Hastanesi, Gogus Cerrahisi Bolumu, Malatya, 4Aksaray Devlet Hastanesi, Gogus Cerrahisi Bolumu, Aksaray, 5Gazi Universitesi Tip Fakultesi, Gogus Cerrahisi Bolumu, Ankara, Turkiye Akciger Kist Hidatik Cerrahisi / Surgery of the Lung Hydatic Cysts Surgical Treatment of the Lung Hydatid Cysts; Analysis of the 73 Patients

Nonossifying fibroma of rib.

Nbenign lesion seen in the first 2 decades of life, occurring commonly in the long bones of lower extremities. Biopsy is required for symptomatic lesions and for those that develop in unusual sites and outside the usual age of presentation [1].Histologically, therearenoneoplastic features. It is considered to be a developmental bony defect that is usually self-limiting, with spontaneous resolution [2]. A 48-year-old man was admitted for left side back pain. His pain had been present since he was 15 years old but had progressed and become unbearable during the last 6 months. Radiologic evaluation revealed an expansile bone lesion on the posterior aspect of the left 10th rib (Fig 1A, negative image of chest; 1B, left lateral three-dimensional view of thorax). A subtotal 10th