Mukarram H. Zaghal

Complexes of 2-(2′-pyridyl)quinoline and 3,6-Di(4′-pyridyl)-S-tetrazine

Abstract The reactions of 2-(2′-pyridyl)quinoline (pq) with RhCl 3 · 3 H 2 O, K 3 RhBr 6 (prepared in situ ), [Rh(CO) 2 Cl] 2 and M(PhCN) 2 X 2 (M=Pd, Pt; X= Cl, Br, I) and 3,6-di(4′-pyridyl)-1,2,4,5-S-tetrazine (s-dpt) with [Ru(bpy) 2 ClNO](PF 6 ) 2 have been investigated. The new complexes cis -[Rh(pq) 2 Cl 2 ]- (PF 6 ), cis -[Rh(pq) 2 Br 2 ]Br, cis -[Rh(pq) 2 Cl 2 ] [Rh- (CO) 2 Cl 2 ]·H 2 O, cis -Pd(pq)X 2 (X=Cl, Br), cis - Pt(pq)X 2 (X=Cl, Br, I) and [{(bpy) 2 ClRu} 2 -dpt]- (PF 6 ) 2 ·3H 2 O have been characterized by elemental analyses, conductivity and cyclic voltammetric measurements, infrared, electronic absorption and 1 H NMR data.

Complexes of palladium, platinum and rhodium with 2,2′-biquinoline and 2-(2′-pyridyl)quinoline

SummaryThe reactions of 2,2′-biquinoline(biq) with M(PhCN)2X2 (M=Pd; X=Cl or Br; M=Pt, X=Cl, Br or I), K2PtCl4 and RhCl3·3H2O and of 2-(2′-pyridyl)quinoline (pq) with K2PtCl4 and RhCl3·3H2O have been investigated. The isolated complexescis-[Pd(biq)X2] (X=Cl or Br),cis-[Pt(biq)Cl2],cis-[Pt(biq)Cl2]·H2O,trans-[Pt(biq)2Br2]·5H2O, [Pt3(biq)2I6],mer-[Rh(biq)Cl3-(H2O)] andmer-[Rh(pq)Cl3(H2O)] have been characterized by elemental analyses, conductivity measurements, i.r., electronic, and1H n.m.r. spectra. The reaction of pq with K2PtCl4 in 1M H2SO4 gave the salt 2-(2′-pyridyl) quinolinium tetrachloroplatinate(II) pentahydrate, (pqH)2[PtCl4]·5H2O; when the reaction was carried out in aqueous acetone,cis-[Pt(pq)Cl2] was obtained. A new method for the synthesis ofcis-[Rh(biq)2X2]X (X=Cl or Br) is described; both compounds have been further characterized by1H n.m.r.

Interconversion of copper(II) to copper(I): synthesis, characterization of copper(II) and copper(I) 2,2′-biquinoline complexes and their microbiological activity

The complexes [Cu(biq)2]Cl2 and [Cu(biq)2]BF4·biq (biq = 2,2′-biquinoline) have been prepared and characterized. The interconversion to copper(I) complex [Cu(biq)2]BF4·biq, from [Cu(biq)2]Cl2 has been established. The new complexes have been characterized by elemental analysis, conductivity and magnetic measurements, IR, UV-vis and 1H- and 13C-NMR spectroscopy. The X-ray analysis of the complex [Cu(biq)2]BF4·biq supports the assumption of the interconversion of copper(II) to copper(I) in this case. The crystal structure shows that geometry around the metal is severely distorted from Td, and displays many supramolecular motifs incorporating both hydrophobic (aryl···aryl) and hydrophilic (C–H···F) intermolecular interactions. The microbiological activity of the complexes against bacteria and fungi was found to be high against Candida albicans, and slight to moderate against bacteria. The antimicrobial activity of [Cu(biq)2]BF4·biq was slightly better than that observed for [Cu(biq)2]Cl2 against both bacteria and fungi.

SUBSTITUTION REACTIONS OF CIS-DICHLOROBIS (2,2'-BIQUINOLINE)RHODIUM(III) CHLORIDE

Abstract The substitution reactions of the title complex cis-[Rh(pq)2C12]Cl with I−, ethylenediamine (en), 2,2′-bipyridine (bipy), the oxalate dianion (ox), pyridine (py) and NO2− have been investigated. The new complexes cis-[Rh(pq)2ICl]I·2H2O, [Rh(pq)(H2O)(en)Cl](PF6)2, [Rh(pq)2(bipy)](PF6)3·2H2O, [Rh(pq)2(ox)]PF6, cis-[Rh(pq)2(py)Cl](PF6)2·2H2O and cis-[Rh(pq)2(NO2)Cl]Cl·3H2O have been characterized by elemental analysis, conductivity measurements, IR, electronic absorption and 1H and 13C NMR spectra.

MUTAGENIC ACTIVITY OF RHODIUM(III) COMPLEXES WITH 2,2'-BIQUINOLINE AND 2-(2'-PYRIDYL)QUINOLINE

Abstract The mutagenic activity of the rhodium(III) complexes with 2,2′-biquinoline(biq) and 2-(2′-pyridyl)quinoline(pq) namely, mer - and fac -[Rh(pq)Cl 3 (H 2 O)], cis -[Rh(NN) 2 X 2 ]X (NN = biq or pq; X = Cl, Br) and cis -[Rh(pq) 2 Cl 2 ] [Rh(CO) 2 Cl 2 ]·H 2 O, was investigated in strains of Salmonella typhimurium TA1530 (hisG46, Δgal, Δuvr, R − ) and TA98 (hisD3052, ΔuvrB, rfa, R + ). All of the complexes studied appear to be active in inducing both base substitution and frame shift mutations. The complex cis -[Rh(biq) 2 Cl 2 ]Cl exhibits the highest activity in both strains and has the lowest toxicity.

Substituted dipyridylpyridazine rhodium(III) complexes

Abstract3,6-Bis(2′-pyridyl)pyridazine derivatives (n-dppn) react with hydrated rhodium(III) chloride and bromide (prepared in situ) to give cis-[Rh(n-dppn)2Cl2]PF6·xH2O (n = 5, 6, 7, 8) and cis-[Rh(n-dppn)2Br2]Br·xH2O (n = 5, 7) complexes, which have been characterized by elemental analyses, conductivity measurements, i.r., electronic and 1H- and 13C-n.m.r. spectra.

Complexes of substituted dipyridylpyridazines with palladium(II) and platinum(II)

Reactions of 3,6-bis(2′-pyridyl)pyridazine derivatives (n-dppn)¶ with MX2(PhCN)2 (M = Pd, Pt; X = Cl, Br) have been investigated. The new complexes cis-[PdCl2(n-dppn)] (n = 5, 6, 8, 12), cis-[PtCl2(n-dppn)] · H2O (n = 5, 6), cis-[PtCl2(8-dppn)] and cis-[PtBr2(5-dppn)] have been characterized by elemental analyses, conductivity measurements, infrared, electronic and 1H-NMR spectra. ¶For the n-dppn ligands, n stands for the size of the cyclic aliphatic ring on positions 4 and 5 of the pyridazine ring, n = 5, 6, 8, and 12.

Synthesis of 2,2′-bipyrimidine platinum(II) complexes

Multinuclear Pt(II) complexes of 2,2′-bipyrimidine (bipm) were prepared and characterized by elemental analyses and standard spectroscopic techniques. The complexes were formulated as [Pt(bipm)2][PtCl4]PhCN (1), [Pt3(μ-bipm)2(bipm)2]Cl6 (2), [Pt2(μ-bipm)(bpy)Cl2]Cl2 (3), [Pt3(μ-bipm)2(biq)2]Cl6·Me2CO·MeCN (4), [Pt3(μ-bipm)2(dmg)2]Cl2·MeCN (5) and [Pt5(μ-bipm)2(dmg)2]Cl8·2PhCN (6), [Pt3(μ-bipm)2(bpy)2]Cl6·2Me2CO·6PhCN (7), [Pt4(μ-bipm)3(phen)2]Cl8·8PhCN (8), [Pt4(μ-bipm)3(ox)2]Cl4·H2O·2PhCN (9); (bpy = 2,2′-bipyridine; dmg = dimethylglyoxime; ox = oxalate; phen = 1,10-phenanthroline; biq = 2,2′-biquinoline).

Cadmium(II) diallyldithiocarbamato complexes with 2,2′-bipyridine and 1,10-phenanthroline: spectroscopic and crystal structure analysis

Complexes of Cd(II) with diallyldithiocarbamato (hereafter denoted aldtc) and 2,2′-bipyridine (bipy) and 1,10-phenanthroline (phen) are discussed. Derivatives of general formula [Cd(aldtc)2(NN)] [NN = bipy, 1 and phen, 2] have been obtained by direct reaction between Cd(NO3)2 and a 2 : 1 molar ratio of aldtc and NN. The new complexes have been characterized by IR, 1H, and 13C NMR spectroscopy. Their single crystal structures were also determined. Compounds 1 and 2 have severely distorted octahedral coordination around cadmium, defined by an N2S4 donor set. The structure of 1 is isomorphous with the recently reported zinc analogue. The crystal packing of 1 shows different non-classical intermolecular interactions represented in both hydrophilic (π)C–H ··· S and hydrophobic (allyl)C–H ··· C(π) intermolecular interactions. Such interactions result in a chain arrangement of molecules along the crystallographic c-axis. These chains are further connected via π ··· π stacking along with (π)C–H ··· S parallel to b leading to an overall crystal packing that can be regarded as layers of complexes along the bc plane. Molecules in the crystal structure of 2 are arranged into infinite chains, down the b-axis, that are connected by aryl ··· aryl stacking. The chains are further connected to each other in a and c directions via (allyl)C–H ··· S interactions.

Bis-Chelated Pd(II)-Amino Acid Complexes: Substitution Reactions of cis-Dichlorobis(benzonitrile)Palladium(II) with Amino Acids

The substitution reactions of the benzonitrile (PhCN) complex cis-[Pd(PhCN)2C12] with the sodium salts of some amino acids, namely L-tyrosine (tyrH), L-phenylalanine (pheH), L-glutamic acid (gluH), L-glutamine (glnH), L-cysteine (cysH), and glycine (glyH) have been investigated. The isolated complexes [Pd(tyr)2].0.5H2O, [Pd(phe)2].H2O, [Pd(glu)2], [Pd(gln)2].H2O, Na2[Pd(cys)2].0.5Me2CO, and [Pd(gly)2].0.5H2O have been characterized by elemental analysis, conductivity measurements, IR, electronic absorption, and 1H- and 13C-NMR spectra. Based on these data, all amino acid anions are found to behave as bidentates through the ‒NH2 and ‒COO− groups except the cysteinate ion which bonds to Pd(II) through ‒NH2 and ‒S− groups.