Mukesh Srivastava

Chromium mobilization and plant availability — the impact of organic complexing ligands

Pot experiments were conducted to investigate the effect of various organic acids (carboxylic and amino acids) on the uptake and translocation of root-absorbed trivalent chromium by tomato ( Lycopersicum esculentum) plants grown in sand and soil culture. Statistically significant increases in chromium accumulation from Cr(III) treated plants in the presence of increasing concentrations of organic acid suggest the existence of Cr(III) — organic acid interactions in the soil-plant system. However, the amino acids have been less effective in the mobilization of chromium compared to carboxylic acids. The results are discussed on the basis of the potential of organic acids to form complexes with Cr(III).

Flavone-Based Novel Antidiabetic and Antidyslipidemic Agents

The hybrid congeners 62-90 of 6- and 7-hydroxyflavones with aminopropanol have been synthesized and evaluated for their antidiabetic activity in sucrose-challenged low-dosed streptozotocin (STZ)-induced diabetic rats and db/db mice. The optical enantiomers 70a, 70b, 90a, and 90b of two congeners 70 and 90 exhibiting consistent antidiabetic and antidyslipidemic activities were also prepared, and their antidiabetic activity results indicate its association mainly with S isomers. These compounds also lower cholesterol and TG profiles while improving high-density lipoprotein cholesterol to CHOL ratio in db/db mice. The bioavailability of compound 70 and its isomer varies between 27 and 29% whereas that of the more polar compound 90a is poor as determined in rat by oral and intraperitoneal administrations.

Chemistry of Phytopotentials: Health, Energy and Environmental Perspectives

Recent studies have shown that crucifers provide greater cancer protection than a diet high in a general mixture of fruits and vegetables. A diet rich in crucifers, such as Brussels sprouts and broccoli, is inversely associated with the risk of many common cancers. The high concentration of Glucosinolates (GLs) and their hydrolysis products (GLsHP) occurring in crucifers provide this protection through some mechanism. The present article describes the anticarcinogenic bioactivities of novel green bullets (Glucosinolates and their hydrolyzed products) and the mechanism of cancer protection. 4 Section A Health Perspectives bolites called Glucosinolates (GLs) as well as numerous other bioactive compounds that play a role in cancer protection. The plant family Cruciferae (mustard family or Brassicaceae) includes broccoli, parsnip, Brussels sprouts, Chinese cabbage, radish, horseradish, wasabi, white mustard, watercress, and cauliflower. Crucifers also contain many other bioactive components including flavonoids. The chemopreventive effect of cruciferous vegetables is thought to be due to their relatively high content of Glucosinolates (β-thioglucoside N-hydroxysulfates), which distinguishes them from other vegetables. Fig. 1: Cruciferous Vegetables Table 1: Vegetables and fruits of the family Cruciferae Genus species (sub species) Vegetable Armoracia lapathifolia Horseradish Brassica camoestris (rapifera) Turnip Brassica camoestris (oleifera) Rape Brassica napus (napobrassica) Swede Brassica oleracea (capitata) White/red cabbage Brassica oleracea (sabauda) Savoy cabbage Brassica oleracea (gemmifera) Brussels sprouts Brassica oleracea (cauliflora) Cauliflower Brassica oleracea (cymosa) Sprouting broccoli Brassica oleracea (laciniata) Curly kale Brassica pekinensis Chinese white cabbage Lepidium sativum Garden cress Nasturtium officinale Watercress Raphanus sativus Radish Sinapis alba White mustard Carica papaya Papaya Among all of the cruciferous vegetables, broccoli sprouts have the highest level of the glucosinolates relevant to this enzymatic process. Just two or three tablespoons of broccoli sprouts a day provide a powerful dose of Glucosinolates. After broccoli sprouts, cauliflower sprouts are second highest in terms of containing the relevant Glucosinolates.

Effect of selenite and selenate on plant uptake of cadmium by kidney bean (Phaseolus mungo) with reference to Cd—Se interaction

ABSTRACTPot culture experiments have been conducted to study the effect of selenite and selenate pretreatment on the uptake and translocation of root-absorbed cadmium in the kidney bean plant, irrigated with 2 μg mL−1 of Cd. A statistically significant reduction in cadmium uptake with increasing concentration of selenite and selenate (0.5–6.0 μg mL−1) has been observed. Selenite treatment is found to be more effective in decreasing cadmium uptake.

Chalcone-Based Aryloxypropanolamine as a Potential Antidiabetic and Antidyslipidaemic Agent

Poonam Shukla, Mavurapu Satyanarayana, Prem C. Verma, Jaya Tiwari, Atma P. Dwivedi, Rohit Srivastava, Neha Rehuja, Swayam P. Srivastava, Sudeep Gautam, Akhilesh K. Tamrakar, Anil K. Dwivedi, Hari N. Kushwaha, Nagsen Gautam, Shio K. Singh, Mukesh Srivastava, Chandishwar Nath, Ram Raghubir, Arvind K. Srivastava and Ram Pratap* Division of Medicinal and Process Chemistry, Division of Biochemistry, Division of Pharmaceutics, Division of Pharmacokinetics and Pharmaco-dynamics, Division of Biometry and Statistics, Division of Toxicology and Division of Pharmacology, CSIR-Central Drug Research Institute, Sector-10 Jankipuram Extension, Sitapur Road, Lucknow 226 031, India