Muniruddin Ahmed

Antinociceptive activity of Polygonum hydropiper

The hexane, ethylacetate and methanol extracts of Polygonum hydropiper whole plant administered to mice at doses of 250 and 500 mg/kg, showed a significant activity on acetic acid-induced writhing. Within the tested extracts, the ethylacetate one showed the most significant activity.

Antinociceptive activity of the aerial parts of Solanum xanthocarpum.

The methanolic extract of Solanum xanthocarpum aerial parts, given orally at 125, 250 and 500 mg/kg, showed significant antinociceptive activity in mice.

Analgesic sesquiterpene dilactone from Mikania cordata

The crude extract of Mikania cordata (1 and 3 g/kg, p.o.) and deoxymikanolide (1) (10 mg/kg, p.o.) significantly inhibited acetic acid-induced writhing in mice. Three other sesquiterpene dilactones isolated from the same plant, namely mikanolide, dihydromikanolide and scandenolide, did not show significant analgesic activity.

HIGHLY OXYGENATED FUROEREMOPHILANE DERIVATIVES FROM SENECIO ZOELLNERI

Abstract The aerial parts of Senecio zoellneri afforded, in addition to known compounds, five oxygenated furoeremophilane derivatives and three seco -furoeremophilanolides, all of which are probably formed by oxidation of 3β-hydroxy-6β-acyloxyeuryopsin.

Flavone and α-santalene derivatives from Polygonum flaccidum

Abstract Chemical investigation of Polygonum flaccidum revealed the presence of a new acylflavone and an α-santalene derivative. The structures of the compounds were elucidated by high field 1H NMR spectroscopic techniques.

Kaurene derivatives from Lasianthea fruticosa, revision of stereochemistry of related compounds

Abstract Two new kaurene diterpenes, 12α-angeloyloxy and 12α-senecioyloxy-9,11-dehydro-ent-kaur-16-en-19-oic acids, have been isolated from Lasianthea fruticosa. The structures and stereochemistry of the compounds were determined on the basis of spectroscopic techniques and minor chemical transformation. The stereochemistry of a few similar compounds has been revised.

Furoeremophilanes and related compounds from Senecio pachyphyllos

Abstract In addition to known compounds, a new furoeremophilane and two pairs of epimeric acetals with an eremophilane skeleton have been isolated from Senecio pachyphyllos. The structures were elucidated by high field 1H NMR techniques.

A preliminary study on the analgesic activity of Grangea maderaspatana

The methanol extract of the whole plant of Grangea maderaspatana showed a dose-dependent analgesic activity. At doses of 1 and 3 g/kg, the extract significantly (P<0.001) inhibited acetic acid-induced writhing in mice by 50 and 80%, respectively.

A 5-methylcoumarin and glaucolides from Bothriocline amplifolia

Abstract 19-Hydroxy glaucolide A, three hirsutinolides and a derivative of brachycalyxolide were isolated from the aerial parts of Bothriocline amplifolia in addition to ethuliacoumarin. The structure of the latter was elucidated by NMR spectroscopy and that of a new hirsutinolide by comparison of the spectral data with those of a closely related one.

The Secret Linkage Amid Sugar and Heart Disease: Is Sugar Truly Foe Rather thanJust Friend?

Sugar is the crucial cradle of sweetness that embodies a prompt energy boost. It is something that we intake relentlessly and toils to precisely estimate sugar content in diet and food stuff because of its rife distribution [1]. Numerous studies advocated the occurrence of high amounts of added sugars up to 75% of all foods and beverages [2,3]. Owing to the arrival of modern food-processing methods, nowadays added sugar is a significant factor of the human diet. The endorsement for the intake of added sugar is not fixed yet it differs substantively. The World Health Organization praises that added sugar is accountable for less than 10% of total calories and as per Institute of Medicine it is less than 25% [4,5].