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Murali Chebrolu

Novartis

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Publication

Featured researches published by Murali Chebrolu.

Bioorganic & Medicinal Chemistry Letters | 2015

Discovery of 1H-pyrazolo[3,4-b]pyridines as potent dual orexin receptor antagonists (DORAs).

Dirk Behnke; Simona Cotesta; Samuel Hintermann; Markus Fendt; Christine E. Gee; Laura H. Jacobson; Grit Laue; Arndt Meyer; Trixie Wagner; Sangamesh Badiger; Vinod Chaudhari; Murali Chebrolu; Chetan Pandit; Daniel Hoyer; Claudia Betschart

Compound rac-1 was identified by high throughput screening. Here we report SAR studies and MedChem optimization towards the highly potent dual orexin receptor antagonists (S)-2 and (S)-3. Furthermore, strategies to overcome the suboptimal physicochemical properties are highlighted and the pharmacokinetic profiles of representative compounds is presented.

Archive | 2010

Oxazine derivatives and their use as bace inhibitors for the treatment of neurological disorders

Sangamesh Badiger; Murali Chebrolu; Mathias Frederiksen; Philipp Holzer; Konstanze Hurth; Rainer Martin Lueoend; Rainer Machauer; Henrik Moebitz; Ulf Neumann; Rita Ramos; Heinrich Rueeger; Marina Tintelnot-Blomley; Siem Jacob Veenstra; Markus Voegtle

Archive | 2012

NOVEL HETEROCYCLIC DERIVATIVES AND THEIR USE IN THE TREATMENT OF NEUROLOGICAL DISORDERS

Sangamesh Badiger; Murali Chebrolu; Konstanze Hurth; Sébastien Jacquier; Rainer Martin Lueoend; Rainer Machauer; Heinrich Rueeger; Marina Tintelnot-Blomley; Siem Jacob Veenstra; Markus Voegtle

Archive | 2013

Heterocyclic derivatives and their use in the treatment of neurological disorders

Sangamesh Badiger; Murali Chebrolu; Konstanze Hurth; Sébastien Jacquier; Rainer Martin Lueoend; Rainer Machauer; Heinrich Rueeger; Marina Tintelnot-Blomley; Siem Jacob Veenstra; Markus Voegtle

Archive | 2010

Disubstituted heteroaryl-fused pyridines

Sangamesch Badiger; Dirk Behnke; Claudia Betschart; Vinod Chaudhari; Murali Chebrolu; Simona Costesta; Samuel Hintermann; Chetan Pandit

Archive | 2016

derivados de oxazina e seu uso no tratamento de distúrbios neurológicos

Heinrich Rueeger; Henrik Moebitz; Hui Liu; Konstanze Hurth; Lei Li; Marina Tintelnot-Blomley; Markus Voegtle; Mathias Frederiksen; Michael Schaefer; Murali Chebrolu; Philipp Holzer; Rainer Machauer; Rainer Martin Lueoend; Rita Ramos; Sangamesh Badiger; Siem Jacob Veenstra; Ulf Neumann; Xin Xiong

Archive | 2014

Compuestos derivados heterociclicos nitrogenados, inhibidores de la bace-1 o de la bace-2; composicion farmaceutica que los comprende; combinacion farmaceutica; su uso en el tratamiento o prevencion de la enfermedad de alzheimer o un deterioro cognitivo leve.

Sangamesh Badiger; Murali Chebrolu; Konstanze Hurth; Rainer Martin Lueoend; Rainer Machauer; Heinrich Rueeger; Marina Tintelnot-Blomley; Siem Jacob Veenstra; Markus Voegtle; Sébastien Jacquier

Archive | 2013

Compuestos derivados de heterociclos, como inhibidores de bace 1 o 2; composicion farmaceutica que los comprende; combinacion farmaceutica; y su uso para el tratamiento o prevencion de la enfermedad de alzheimer o deterioro cognitivo leve, resistencia a la insulina, diabetes tipo 2, entre otras.

Sangamesh Badiger; Murali Chebrolu; Konstanze Hurth; Sébastien Jacquier; Rainer Martin Lueoend; Rainer Machauer; Heinrich Rueeger; Marina Tintelnot-Blomley; Siem Jacob Veenstra; Markus Voegtle

Archive | 2012

Nouveaux dérivés hétérocycliques et leur utilisation dans le traitement de troubles neurologiques

Sangamesh Badiger; Murali Chebrolu; Konstanze Hurth; Sébastien Jacquier; Rainer Martin Lueoend; Rainer Machauer; Heinrich Rueeger; Marina Tintelnot-Blomley; Siem Jacob Veenstra; Markus Voegtle

Archive | 2012

Derivatives and novel heterocyclic use in treating neurological disorders

Sangamesh Badiger; Murali Chebrolu; Konstanze Hurth; Sébastien Jacquier; Rainer Martin Lueoend; Rainer Machauer; Heinrich Rueeger; Marina Tintelnot-Blomley; Siem Jacob Veenstra; Markus Voegtle

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Collaboration

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Sangamesh Badiger

Novartis

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Heinrich Rueeger

Novartis

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Konstanze Hurth

Novartis

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Marina Tintelnot-Blomley

Novartis

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Markus Voegtle

Novartis

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Rainer Machauer

Novartis

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Rainer Martin Lueoend

Novartis

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Siem Jacob Veenstra

Novartis

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Sébastien Jacquier

Novartis

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Henrik Moebitz

Novartis

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