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Featured researches published by Murat Cakir.


Pediatrics International | 2007

Menstrual pattern and common menstrual disorders among university students in Turkey.

Murat Cakir; Ilke Mungan; Taner Karakas; Ilknur Girisken; and Aysenur Okten

Background: Menstrual disorders may affect the life of adolescents and young adult women, and may sometimes cause serious problems. The patterns of menstrual cycles were analyzed for association with age of menarche, prevalence of menstrual irregularity, dysmenorrhea, prolonged menstrual bleeding, and effect of menstrual disorders, especially dysmenorrhea, on social activities and school attendance among the female students.


Clinical Pediatrics | 2006

Analysis of Children with Peripheral Lymphadenopathy

Nilgun Yaris; Murat Cakir; Emin Sözen; Umit Cobanoglu

In this study, the clinical and laboratory features of children with lymphadenopathy were evaluated. Over a 3-year period, 126 patients were referred to the clinic for lymphadenopathy. Twenty-eight of cases have diseases mimicking lymphadenopathy; 98 (mean age: 86 ± 55 months) have lymphadenopathy. Localized, limited, and generalized involvement was found in 52%, 30%, and 18% of patients. The most common localization was the head and neck region. The causes of lymphadenopathy were benign diseases in 75 patients. Sixty percent were reactive lymphadenopathy, 39% were lymphadenitis. Lymphadenitis was more frequently localized and bigger than 3 cm compared with reactive adenopathy (p = .02, p = .004). Twenty-three patients have malignant diseases whose mean age was higher than others (p = .002). The enlargement of supraclavicular nodes was more likely due to malignant disease (p = .001). The risk of malignant disease was higher in patients who had generalized lymphadenopathy, lymph nodes bigger than 3 cm, hepatosplenomegaly, and high lactate dehydrogenase levels. In conclusion, this study pointed out the important clues for the differential diagnosis, which were present in the history, physical, and laboratory findings.


Annals of Tropical Paediatrics | 2009

Crimean-Congo haemorrhagic fever among children in north-eastern Turkey.

Embiya Dilber; Murat Cakir; E. A. Acar; Fazil Orhan; Nilgun Yaris; Elif Bahat; Ayşenur Ökten; Erol Erduran

Abstract Aim: To analyse the epidemiological and clinical features of children with Crimean–Congo haemorrhagic fever (CCHF) in north-eastern Turkey. Methods: A retrospective study of demographic features and physical and laboratory findings in 21 children with CCHF is described. Clinical course, treatment modalities and outcome were analysed. Results: Most patients were admitted in June and July 2008; most were from the Gumushane and Kelkit valleys and half of them lived in rural areas. Mean (SD) age was 10.3 (3.9) years and the disease was more common in males (71.4%). Approximately 70% had a history of tick bite. The main symptoms were fever (17, 80.9%), nausea (11, 52.3%), malaise (10, 47.6%) and headache (7, 33.3%). At initial examination, approximately 70% of patients had leukopenia and 65% had thrombocytopenia. Anaemia developed during follow-up in six patients. Liver involvement was seen in 12 patients and one patient had acute tubular necrosis. Six patients had haemophagocytosis. Patients were hospitalised for a median 8 days (range 3–22) and nine patients had bleeding from various sites approximately 3–5 days after hospitalisation. Subcutaneous haematoma (6), especially epistaxis and at venepuncture sites (6) were the most common sites of bleeding. Pulmonary haemorrhage developed in two patients and they required ventilatory support. Overall mortality related to CCHF was 4.7% (one patient). Conclusion: Early diagnosis of CCHF and early referral to specialised centres are important for outcome. Exceptional epidemics may be seen in future owing to ecological and environmental changes.


Rheumatology International | 2006

Henoch-Schönlein purpura: a case with atypical presentation

Mukaddes Kalyoncu; Murat Cakir; Erol Erduran; Ayşenur Ökten

We report on a case of Henoch-Schönlein purpura (HSP) with pulmonary hemorrhage and severe renal involvement. The patient also had active carditis related to acute rheumatic fever. He died despite intensive treatment. Regarding this case, we discuss the pathogenesis and clinical findings of pulmonary hemorrhage and active carditis in HSP.


Annals of Tropical Paediatrics | 2009

Listeria monocytogenes meningitis in two immunocompetent children.

Embiya Dilber; A. Aksoy; Murat Cakir; Elif Bahat; T. Kamaşak; B. Dilber

Abstract Listeria monocytogenes is an uncommon cause of bacterial meningitis beyond the neonatal period. Patients with immunosuppression or neoplastic disease are at increased risk of developing serious invasive disease, particularly meningitis. L. monocytogenes meningitis in two previously healthy, immunocompetent children aged 7 years and 18 months is described. One of them was successfully treated with ampicillin and amikacin. In the other there was resistance to ampicillin, and meropenem, vancomycin and amikacin were given. One patient developed unilateral abducens paralysis and inappropriate antidiuretic hormone secretion. L. monocytogenes should be suspected in children with bacterial meningitis who fail to respond to empirical antibiotic therapy.


Annals of Tropical Paediatrics | 2006

Henoch-Schonlein purpura in north-eastern Turkey

Murat Cakir; Fazil Orhan; Ilke Mungan; F. Müjgan Sönmez; Yakup Aslan; Mukaddes Kalyoncu; Erol Erduran; Yusuf Gedik; Ayşenur Ökten

Abstract Aim: To evaluate the epidemiological and clinical findings in children with Henoch-Schönlein purpura (HSP) admitted during a 10-year period, 1995 to 2004, and to compare them with series from other parts of the world. Methods: The medical records of all children aged 17 years or less admitted with a diagnosis of HSP to the Department of Pediatrics of Karadeniz Technical University were evaluated retrospectively for epidemiological and clinical features. Results: Of 116 children, 73 (63%) were boys. The mean (SD) age at presentation was 8.9 (3.7) years and one-third of them were older than 10 years of age. Over half the cases presented between September and January. All patients had the typical skin rash. Gastro-intestinal manifestations were seen in 64 (55.1%) and joint manifestations, common during the early course of the disease, in 73 (62.9%). Two patients required laparatomy, one for acute abdomen and the other for bowel resection owing to intussusception. Renal manifestations were observed in 36 (31%), all within 3 months of initial symptoms, and one patient (0.8%) with nephritic syndrome progressed to end-stage renal disease. Five patients had hypertension without urinary findings. Symptoms recurred in eight patients (6.9%) over a period ranging from 2 to 5 months after complete resolution of symptoms. There was a history of a preceding upper respiratory tract infection in 16 (13.7%) and a streptococcal infection was confirmed by throat culture in 12 of the 42 (28.5%) children at presentation. Conclusion: HSP is generally benign and self-limiting. Hypertension may be seen during the course of the disease without urinary findings. In this area, it seems to affect older children and there is a relatively lower incidence of renal manifestations.


Acta Paediatrica | 2010

Liver cirrhosis in an infant with Chanarin–Dorfman syndrome caused by a novel splice-site mutation in ABHD5

Murat Cakir; C Bruno; Aysegul Cansu; Umit Cobanoglu; Erol Erduran

We described a Turkish girl with Chanarin–Dorfman syndrome who developed liver cirrhosis in the early infancy. She had all the clinical features of Chanarin–Dorfman syndrome such as ichthyosis, Jordan’s anomaly, fatty liver disease and mild ectropion. The diagnosis was confirmed with a novel ABHD5 mutation. Liver steatosis or steatohepatitis with or without hepatomegaly is the predominant finding of Chanarin–Dorfman syndrome. Cirrhosis has been reported in patients with long‐duration disease.


Acta Paediatrica | 2007

Atopy in children with chronic hepatitis B virus infection

Murat Cakir; Taner Karakas; Fazil Orhan; Ayşenur Ökten; Yusuf Gedik

Aim: To investigate whether immune responses against chronic HBV infection in children have an effect on prevalence of allergic diseases and atopy.


Digestive and Liver Disease | 2012

Liver involvement in children with Familial Mediterranean fever

Fatih Unal; Murat Cakir; Masallah Baran; Cigdem Arikan; Hasan Ali Yuksekkaya; Sema Aydogdu

AIM Familial Mediterranean fever is characterised by recurrent, febrile, inflammatory attacks of the serosal membranes. Prolonged inflammatory response is triggered secondary to cytokine stimulation due to reduced activity of pyrin. Inflammatory cytokines play major role in the pathogenesis of acute liver injury; and chronic, recurrent cytokine production may cause chronic hepatitis/cirrhosis. We aimed to analyse liver involvement in children with Familial Mediterranean fever. PATIENTS The study included 58 patients with Familial Mediterranean fever. Patients with liver involvement were examined in detail. RESULTS Liver involvement was seen in 11 of 58 patients (18.9%). Two patients (3.4%) had abnormal liver enzymes during the diagnostic evaluation, whilst 9 patients (15.5%) were admitted with the features of liver diseases, and had final diagnosis of Familial Mediterranean fever (2 had Budd-Chiari syndrome, 5 had chronic hepatitis/cirrhosis, 2 had acute hepatitis). None of the demographic factors or laboratory findings was different between the patients with or without liver involvement M694V allele was more common in patients with liver involvement but did not reach significant difference (50% vs. 33.6%, p=0.21). All the patients showed clinical and laboratory improvement after colchicine. CONCLUSION Paediatric hepatologists must keep Familial Mediterranean fever in mind in the patients with cryptogenic hepatitis/cirrhosis especially in regions where hereditary inflammatory diseases are common.


Pediatric Hematology and Oncology | 2004

Castleman Disease: A Case with Atypical Presentation

Nilgun Yaris; Murat Cakir; Mukaddes Kalyoncu; Kadriye Yildiz; Ayşenur Ökten

Castleman disease is a benign lymphoproliferative disorder characterized by enlarged lymph nodes. In children the disease is rare, usually localized, and asymptomatic. Resection of the node is almost always curative. A case is reported that was diagnosed as hyaline vascular-type Castleman disease at 1 year of age. The disease recurred from infraclavicular region in addition to primary site, even though total excision was performed. Although the disease is mullticentric after recurrence, the patient has no systemic symptoms.

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Ayşenur Ökten

Karadeniz Technical University

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Mukaddes Kalyoncu

Karadeniz Technical University

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Fazil Orhan

Karadeniz Technical University

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Ilke Mungan

Karadeniz Technical University

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Nilgun Yaris

Karadeniz Technical University

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Erol Erduran

Karadeniz Technical University

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Embiya Dilber

Karadeniz Technical University

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Ulaş Emre Akbulut

Karadeniz Technical University

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Elif Sag

Karadeniz Technical University

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Taner Karakas

Karadeniz Technical University

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