Murat Yiğit

Synthesis of ruthenium(II) N-heterocyclic carbene complexes and their catalytic activities in transfer hydrogenation of ketones

Three RuCl2(η6-arene, η1-carbene) and two RuCl2(NHC)(arene) complexes have been prepared by the reaction of bis(1,3-dialkylperhydrobenzimidazol-2-ylidene) (1) and bis(1,3-dialkyl-4-methylzimidazolin-2-ylidene) (3) with [RuCl2(arene)]2 in toluene and characterized by elemental analysis, 1H NMR, 13C NMR and IR spectroscopy. The catalytic activities of these complexes were examined in the transfer hydrogenation of aromatic ketones using 2-propanol as hydrogen source.

THE SYNTHESIS OF SOME BENZIMIDAZOLIUM SALTS AND USE AS CARBENE PRECURSORS IN THE HECK AND SUZUKI REACTIONS

Novel 1-(2-diisopropylaminoethyl)-3-alkylbenzimidazolium salts as N-heterocyclic carbene precursors 2a-g were prepared by quartemazition of 1-(2-diisopropylaminoethyl)benzimidazoles in DMF with alkyl halides. The salts were characterized spectroscopically and in situ formed complexes from Pd(OAc) 2 and 2 have been tested as catalyst in homogenous Heck and Suzuki reactions.

The Synthesis of Some Perhydrobenzimidazolinium Salts and Their Application in Pd-Carbene Catalyzed Heck and Suzuki Reactions

Novel 1,3-dialkylperhydrobenzimidazolinium chloride salts were prepared as precursors of N-heterocyclic carbenes 3a-e by reacting N,N’-dialkylcyclohexandiamine, triethyl orthoformate and ammonium chloride. The salts were characterized spectroscopically and the complexes formed in situ from Pd(OAc)2 and 3 have been tested as catalysts in homogenous Heck and Suzuki reactions.

Schiff bases and their amines: Synthesis and discovery of carbonic anhydrase and acetylcholinesterase enzymes inhibitors

Three series of symmetrical Schiff bases were synthesized from 1,2‐diaminoethane, 1,3‐diaminopropane and 1,4‐diaminobutane and substituted benzaldehydes, and reduced by sodium borohydride to the corresponding benzylic diamines 4–6. All of the compounds obtained were characterized using elemental analysis, FT‐IR, 1H NMR, and 13C NMR spectroscopy. The enzyme inhibitory properties of these compounds were tested and the influence of the alkane chain length and the substituents on the phenyl group on the enzyme inhibition activity were examined. The novel Schiff bases and their amine derivatives (1a–d, 2a–d, 3b–d, 4a–c, 5a–c, 6a, 6c, 6d) were effective inhibitors of the cytosolic carbonic anhydrase I and II isoforms (hCA I and II), and acetylcholinesterase (AChE) with Ki values in the range of 159.43 ± 30.03 to 563.73 ± 115.30 nM for hCA I, 104.88 ± 18.44 to 524.32 ± 95.03 nM for hCA II, and 3.95 ± 0.74 to 30.83 ± 6.81 nM for AChE.