Muriel E. Johnston

The Measurement of Liver Circulation by Means of the Colloid Disappearance Rate: I. Liver Blood Flow in Normal Young Men

A method for calculating the liver blood flow by means of the rate of disappearance of colloidal chromic phosphate from the blood has been reviewed. This method has been applied to the study of liver circulation in a group of 29 fasting normal men. The significance of the colloid disappearance rate constant as a physiologic expression of the liver blood flow has been discussed and the average value obtained for this constant in normal young men was 0.287 ± 0.007 min.−1 Extra hepatic colloid localization, hepatic efficiency for colloid removal, speed of mixing, and type and time of sampling have been discussed.

The induction of tumors in the rat by astatine-211.

Exposure of rats to sublethal amounts of At/sup 211/ results in the early appearance of large numbers of mammary tumors, many of them malignant, and in the production of an altered functional state simulating menopause. It is evident that the tumor induction is not yet tested for its association with radiation exposure separately from the endocrine disturbance. (auth)

Studies of Human Peripheral Blood Flow: The Effect of Injection Volume on the Intramuscular Radiosodium Clearance Rate

The effects of changes in injection volume on the intramuscular radiosodium clearance rate was investigated in six normal young men. The clearance rate was found to be quite sensitive to the volume of solution injected, and an increase in the rate of clearance corresponding to a decrease in volume was uniformly noted. Rigid control of the injection volume is necessary when this method is used for regional blood flow measurements.

The Measurement of Total "Sodium Space" and Total Body Sodium in Normal Individuals and in Patients with Cardiac Edema

Total sodium space and total body sodium contents were determined in four groups of individuals with the aid of radiosodium24. There appears to be an increase in these values with age, but the presence of well compensated cardiovascular disease in the older age group does not significantly alter the magnitude of these measurements. When congestive failure with edema occurs, there is a marked increase in total sodium space and total body sodium. The increase in total sodium space shows a good correlation with the clinical degree of edema.

Evidence for function of aberrant thyroid tissue in thymus of rats.

Summary Aberrant thyroid follicles have been found in the thymi of female Sprague-Dawley rats. The accumulation of I131 by such follicles, shown autoradiographically, indicated their functional nature.

THE METABOLSIM AND TOXICITY OF RADIUM-223 IN RATS

UCRL 8189 UNIVERSITY OF CALIFORNIA THE METABOLISM AND TOXICITY RADIUM-223 IN RATS OF TWO- WEEK LOAN COpy ,Ii This is a library Circulating Copy which may be borrowed for two weeks. For a personal retention copy, call Tech. Info. Diuision, Ext. 5545

CORRELATION OF HISTOCHEMICAL, AUTORADIOGRAPHIC, AND MICRORADIOGRAPHIC DEMONSTRATIONS OF TISSUE CALCIFICATION

1. The sensitivity and reliability of three representative histochemical tests for calcium (von Kóssa, ferrocyanide, and alizarin) have been compared by applying them to vertebral ossification centers in the rat fetus. 2. The histochemical results were controlled by concurrent study of calcium45 autoradiographs and of soft x-ray microradiographs of the same or adjacent sections. 3. Microradiographs and von Kóssa-positive reactions produced essentially identical representations of mineralized bone and cartilage. 4. The von Kóssa reaction coincided with high grain density regions of calcium45 deposition in stripping-film autoradiographs but did not reflect the sparser densities. 5. The ferrocyanide reaction showed gradients of staining density corresponding in many sites with the varying degrees of radiocalcium density. Faint ferrocyanide reactions extended beyond the limits of microradiographic mineral opacity. 6. The resolution obtained with contact autoradiographs and alizarin dye-lake histological preparations was inadequate for study at high magnification.