Murray Dworetzky

Prometheus in Gloucestershire: Edward Jenner, 1749-1823

Abstract Thou shalt not be afraid for the pestilence that walketh in darkness nor for the destruction that wasteth at noon day. 1

Studies of materials derived from staphylococcus: III. Protective action of gamma globulin against the anaphylactoid effects of a staphylococcal bacterial fraction

Abstract Through use of the agar precipitin method, human sera have been shown to contain antibodies directed against both culture filtrates and bacterial extracts of staphylococci. Most of the antibodies were directed against culture filtrates. All of the Staphylococcus aureus strains studied produced antigens which reacted with HGG, while only two of nine Staphylococcus albus strains formed antigens reacting with HGG. This suggests a relationship between the pathogenicity of a strain of staphylococcus and its ability to stimulate antibody production.

Certification and recertification

Date Due_______________ I certify that continued SNF inpatient care is necessary for the following reason(s): _____________________________________________________________________________________________________ _____________________________________________________________________________________________________ _____________________________________________________________________________________________________ _____________________________________________________________________________________________________ _____________________________________________________________________________________________________ _____________________________________________________________________________________________________ I estimate that the additional period of SNF inpatient care will be ___________ days (or ___________ weeks). Plans for post-SNF care are: ❑ Home Health Agency ❑ Office Care ❑ Other ____________________________ Continued SNF care is for same condition(s) for which patient received inpatient hospital services: ❑ Yes ❑ No

Small-dose emulsion treatment of ragweed pollinosis. A double-blind study continued for three seasons

T he use of emulsified pollen extract in the treatment of rhinitis due to allergy has been increasingly popular since its introduction by Loveless1 and the extension of her original work by Bro&n .2 Although the reports are too numerous to mention, there have been few well-controlled studies”-” since Loveless6 published the results of a double-blind study in 1957. Only two such studies with aqueous therapy have been reported.‘, y Because all reports prior to the initiation of our study, and most of them since, have been primarily concerned with determination of the largest dose that could be given without producing a reaction, we became interested in evaluating the effects of very small doses, since reaction is one of the problems in emulsion therapy. One purpose of our study was to determine the results of treatment with relatively small doses of emulsified pollen extract in rhinitis caused by allergy to ragweed pollen. A double-blind study was carried out through the allergy seasons of 1960, 1961, and 1962. We felt that an understanding of the difficulties in establishing proper experimental design was perhaps more important than the actual results themselves. The study was initiated as a pilot study in 1960 in cooperation with the Committee on Specific Therapy of the American Academy of Allergy. E’ortyfive patients with ragweed allergic rhinitis were selected from The New York Hospital Allergy Clinic. These patients were grouped in pairs matched as closely as possible according to sex, duration of disease, previous aqueous hypo-

Studies of materials derived from staphylococcus: IV. Precipitating antibodies to staphylococcal antigens in human sera☆

Abstract Through use of the agar precipitin method, human sera have been shown to contain antibodies directed against both culture filtrates and bacterial extracts of staphylococci. Most of the antibodies were directed against culture filtrates. All of the Staphylococcus aureus strains studied produced antigens which reacted with HGG, while only two of nine Staphylococcus albus strains formed antigens reacting with HGG. This suggests a relationship between the pathogenicity of a strain of staphylococcus and its ability to stimulate antibody production.