Murray F. Brennan

Intraductal papillary‐mucinous neoplasms of the pancreas

Intraductal papillary‐mucinous neoplasms (IPMNs) of the pancreas are intraductal tumors with variable amounts of papilla formation, mucin production, and cytoarchitectural atypia. Associated invasive carcinomas, reported to occur in up to 30% of patients, often are mucinous and clinically indolent.

Clinicopathologic correlates of solitary fibrous tumors.

Solitary fibrous tumors (SFTs) are rare fibrous neoplasms. Since their initial description as arising from the pleura, SFTs have been reported at a wide range of anatomic sites. To the authorss knowledge, there are no large series reporting both thoracic and extrathoracic SFTs nor are there any large series that analyze clinicopathologic correlates of tumor behavior.

The management of unicentric and multicentric Castleman's disease

Castlemans disease (CD), or angiofollicular lymph node hyperplasia, creates both diagnostic and therapeutic dilemmas for most physicians. For patients with this rare and poorly understood disease, the optimal therapy is unknown. The authors report their experience during the years 1986–1997 with this uncommon clinicopathologic entity.

Extremity and trunk desmoid tumors

The natural history of desmoid tumors remains an enigma. Previous reports attempting to identify their biology have included recurrent and primary tumors as well as tumors from both intra‐ and extra‐abdominal sites. The purpose of this study was to analyze patients with primary extremity and trunk desmoid tumors treated and followed at a single institution and to determine factors influencing disease free survival.

Prognostic factors for recurrence and survival in head and neck soft tissue sarcomas

Background. Soft tissue sarcomas of the head and neck represent uncommon malignant neoplasms. With the exception of orbital and parameningeal sites, the treatment of sarcomas in the head and neck has not been standardized. The authors used a prospectively collected database of adult soft tissue sarcomas to identify prognostic factors for local control and survival.

Multifactorial Analysis of the Survival of Patients with Distant Metastasis Arising from Primary Extremity Sarcoma

Despite optimal multimodality limb‐sparing therapy for extremity soft tissue sarcoma (STS), a significant number of patients develop distant metastasis. The objective of this study was to analyze patterns of metastatic disease and define prognostic factors for survival in a large group of patients followed prospectively at a single institution.

Clinicopathologic Analysis of Patients with Adult Rhabdomyosarcoma

Rhabdomyosarcoma (RMS) in adults (age ≥ 16 years) is rare, accounting for less than 3% of adult soft tissue sarcomas. There is little information describing the disease biology or clinicopathologic factors that influence survival in adults with RMS. The objective of this study was to define the factors in patients with adult RMS that predict outcome, disease progression, and survival.

Validation and adaptation of a nomogram for predicting the survival of patients with extremity soft tissue sarcoma using a three-grade system

A nomogram for predicting long term tumor‐specific death in patients with soft tissue sarcoma (STS) was developed at the Memorial Sloan‐Kettering Cancer Center (MSKCC).

Validation of the postoperative nomogram for 12-year sarcoma-specific mortality

On the basis of a prospectively followed cohort of adult patients with primary soft tissue sarcoma (STS) who were treated at Memorial Sloan‐Kettering Cancer Center (MSKCC; New York, NY), a nomogram for predicting sarcoma‐specific mortality was developed. Although this nomogram was found to be accurate by internal validation tests, it had not been validated in an external patient cohort, and thus its universal applicability remained unproven.

A comparison of staging systems for localized extremity soft tissue sarcoma.

Staging systems for soft tissue sarcoma (STS) are important to identify patients with similar systemic risk who might benefit from specific treatments. This study compared four commonly used staging systems for predicting systemic outcomes of patients with localized extremity STS, as proposed by the fourth and fifth editions of the American Joint Committee on Cancer/International Union Against Cancer (AJCC/UICC) staging system, the Memorial Sloan‐Kettering Cancer Center (MSK) system, and the Surgical Staging System (SSS) of the Musculoskeletal Tumor Society.