Mustapha Rahmouni

Catalysed esterifications in room temperature ionic liquids with acidic counteranion as recyclable reaction media

Esterification reactions of acetic acid, methoxyacetic acid and methylmalonic acid with neo-pentanol, hexanol, heptanol and decanol have been investigated in three ionic liquids with hydrogen sulphate, dihydrogen phosphate as counteranions and also two ionic liquids modified with HPF6 as catalyst. The nature of both the counteranion and cation influence the behavior of the catalyst. Good yields and high selectivities were obtained and all the produced esters could be easily recovered due to their immiscibility with the ionic liquid as green reaction medium. 2002 Elsevier Science B.V. All rights reserved.

A new route to pyrimido [1,6-a] benzimidazoles : Reactivity of activated 2-benzimidazoles with N-Acyl imidates as β-dielectrophiles under microwave irradiation

Abstract Activated 2-benzimidazoles react with a variety of N-Acyl imidates under microwave irradiation in open vessels to give the corresponding pyrimido [1,6-a] benzimidazoles.

One-Pot Synthesis of 5-Arylidene-2-Imino-4-Thiazolidinones under Microwave Irradiation

A rapid and easy solvent free one-pot synthesis of 5-arylidene-2-imino-4-thiazolidinones by condensation of the thioureas with chloroacetic acid and an aldehyde under microwave-irradiation is described.

A NEW ACCESS TO 2,3-DIHYDRO IMIDAZO 1,2-C PYRIMIDINES

Abstract A simple and efficient route to 2,3-dihydro imidazo [1,2-c] pyrimidines 3(a-e) by reaction under focused microwave irradiation of N-Acyl imidates 1 with imidazolidine ketene aminals 2 is described.

A new route to α-hetero β-enamino esters using a mild and convenient solvent-free process assisted by focused microwave irradiation

New α-hetero β-enamino esters 5 (X = NH, O, S) are obtained in good to excellent yields by transamination reactions from ethyl 3-dimethylamino acrylate 2(a-c) and various volatile amines 3(a-e) using solvent-free conditions assisted by focused microwave irradiation. Most of the α-hetero β-enamino ester derivatives 3 present a (E)-s-cis/trans conformation.

1,3-Dipolar cycloadditions of aldehydes or imines with carbonyl ylides generated from epoxides : Classical heating and microwave irradiation

Abstract Cycloadditions of aldehydes with carbonyl ylides to give dioxolanes have been carried out without solvent under microwave irradiation. The reactions proceeded in similar yields and stereoselectivities, but in shorter reaction times, than those obtained in toluene at reflux using an oil bath. Cycloadditions conducted between imines and carbonyl ylides using the same protocol were less efficient because the oxazolidines formed proved unstable under the reaction conditions.

An expeditious, environment-friendly, and microwave-assisted synthesis of 5-isatinylidenerhodanine derivatives

A series of nine 5-arylidenerhodanine derivatives was prepared in good yields and purity without the use of a solvent or catalyst under microwave-assisted condensation with some substituted isatins. All 5-arylidenerhodanines were evaluated as possible inhibitors of the CK1α/β, CDK5/p25, and GSK-3α/β kinases. None of them showed substantive inhibitory activity against these kinases when evaluated at the concentration of 10 μM.

Stereoselective synthesis of (2E) 3‐amino‐2‐(1H‐benzimidazol‐2‐yl)acrylate and symmetric bisacrylates by transamination reactions

A range of various amines 2(a–i) was tested in transamination reactions using ethyl 2-(1H-benzimidazol-2-yl)-3-dimethylamino-acrylate 1a. The (E)-s-cis/trans conformation of some representative products 4 was analyzed by 1H and 13C NMR spectra. The C-2/C-3 bond of the compounds 3(a–i) is strongly polarized by a push-pull effect. In the same manner, reactions of ethyl 2-(benzoxazol-2-yl)-3-dimethylamino-acrylate 1c with 1,4-diaminobenzene 2i, ethylenediamine 2i, and 1,5-diaminomaphthalene 2k have been investigated and gave directly the corresponding symmetric bis-acrylates 4(a–c) in good yields.