Mutsuyo Asai

Videomicroscopic and histopathological investigation of intense pulsed light therapy for solar lentigines.

A noncoherent, broadband, intense pulsed light source has been effective for symptoms of photoaging skin as a nonablative method. The purpose of this study was to investigate the mechanism of efficacy of intense pulsed light for solar lentigines, a symptom of photoaging skin, with videomicroscopy and histopathology. Skin lesions of patients with solar lentigines who received one treatment of intense pulsed light were examined. Sixteen of 20 patients showed tiny crusts clinically. These tiny crusts were confirmed to be micro-crust formation after epidermal injury with sequential observation using videomicroscope and histopathology. Drop-off of micro-crusts with ample melanin pigments lead to clinical improvement of skin lesions. Intense pulsed light with absorption spectrum for melanin induced injury of melanin-containing epidermal cells via photothermal effects, suggesting that intense pulsed light may be a new modality for solar lentigines.

Drug eruption induced by cefcapene pivoxil hydrochloride

Keywords: cutaneous adverse drug reaction; cefcapene pivoxil hydrochloride; antibiotics; medicaments; positive patch test

Allergic contact cheilitis due to glyceryl monoisostearate monomyristate in a lipstick

Case Report After starting to use 3 kinds of lipsticks from unknown Japanese manufacturers, a 23-year-old woman had developed pruritic erythema on her lips within a few days. A positive patch test reaction was seen to 1 of the lipsticks, as is, at D3. The patient was then patch tested with 32 ingredients of this lipstick at appropriate dilutions. Only glyceryl monoisostearate monomyristate 7% pet. was positive at D3 (Table 1). Patch tests with 7%, 1% and 0.1% pet. glyceryl monoisostearate monomyristate in 6 control subjects showed no reactions at D2 or D3.