Myeong-Jin Lee

Foodborne illness outbreaks in Korea and Japan studied retrospectively

The average prevalence of reported foodborne illness from 1981 to 1995 was 2.44 per 100,000 population in Korea, and 28.01 in Japan. The mean case fatality rate in Korea was 0.74% and in Japan, 0.03%. When both prevalence and case fatality rates in Korea and Japan were compared during the same period, the prevalence in Japan was much higher than that in Korea. However, the case fatality rate of patients in Korea was much higher than that in Japan. The distribution of monthly and seasonal patterns of foodborne illness outbreaks strongly indicate the outbreaks may be associated with climatic conditions, frequencies of national holidays, and vacation seasons. Comparison study indicates that the foodborne illness outbreaks in Korea most frequently involved homemade foods (47% of the total cases); in Japan, restaurants accounted for 31.3%. Foodborne illness cases of bacterial origin in Korea were 59.3% of the total and included Salmonella spp. (20.7%). Vibrio (17.4%), Staphylococcus (9.7%), pathogenic Escherichia coli (2.4%), and other species (9.1%); in Japan, 72.8% of the total cases and the majority of the bacterial foodborne illness was caused by Vibrio (32.3%), Staphylococcus (15.9%), Salmonella (14.2%), pathogenic E. coli (3.0%), and other species (7.2%). In conclusion, the outbreaks of foodborne illness in Korea and Japan may be mainly caused by improper food handling, and their occurrences may be differentiated according to food sources.

An epidemiological study of food poisoning in Korea and Japan

The purpose of this study was to make a comparative epidemiological observation on outbreaks of food poisoning between Korea and Japan, during the period from 1971 to 1990. The mean morbidity rate by fiscal year from 1971 to 1990 was 3.0 per 100,000 population in Korea, and 29.2 in Japan. The mean mortality rate, in Korea was 2.48%, and in Japan, 0.07%. When both morbidity and mortality rates in Korea and Japan were compared during same period, the morbidity rate in Japan was much higher than that in Korea. However, the mortality rate of patients in Korea was much higher than that in Japan. Comparison of food poisoning rates according to food preparation facilities in Korea and Japan was also performed; outbreaks in Korea most frequently involved home-made foods (48% of the total cases), while in Japan, restaurants accorded for 32.7%. Foods most commonly incriminated in Korea were seafood, meat and animal products, grains and vegetables, including mushrooms. In Japan, however, unknown causes, followed by seafood, vegetables, and meat and animal products were the most common. Food poisoning of bacterial origin in Korea was 58.6% of the total case, including Vibrio spp. (37.6%), Salmonella spp. (23.1%), Staphylococcus spp. (14.9%), pathogenic E. coli (6.8%) Clostridium spp. (0.5%) and other species (17.1%). In Japan, the majority of bacterial causes were Vibrio spp. (47.3%), Staphylococcus spp. (24.6%), Salmonella spp. (14.8%), E. coli (3.5%), Clostridium spp. (0.2%) and other species (9.6%). In conclusion, the outbreaks of food poisoning in Korea and Japan may be mainly caused by food handling, and their occurrence may be different according to food sources.

DNMT3b 39179GT Polymorphism and the Risk of Adenocarcinoma of the Colon in Koreans

DNA-methyltransferase-3B (DNMT3b) plays an important role in the generation of aberrant methylation in carcinogenesis. DNMT3b SNP has been associated with susceptibility to lung, head, neck, and breast cancer, but its association with the development of colon cancer has not been reported. We investigated the relationship between the 39179G‎T polymorphism in the DNMT3b gene, which is involved in de novo methylation and is associated with the risk of adenocarcinoma of the colon in Koreans. The DNMT3b 39179G‎T genotypes were determined by a PCR-RFLP method in 248 adenocarcinomas of colon cancer patients and in 248 healthy controls matched as to age and sex. When stratified by sex and age, a significantly reduced risk of the combined GT and GG genotypes was observed in younger patients (<59, adjusted OR = 0.255, 95% CI = 0.133–0.489) and in male patients (adjusted OR = 0.383, 95% CI = 0.225–0.652). The DNMT3b 39179G‎T polymorphism may be a genetic determinant of adenocarcinoma of the colon, especially in younger Korean men.

Review of canine rabies prevalence under two different vaccination programmes in Korea

10 LINDSAY, D. S. & BLAGBURN, B. L. (1995) Practical treatment and control of infections caused by canine gastrointestinal parasites. Veterinary Medicine 90,441-443 LOSS, Z. G. & LOPES, C. W. G. (1992) Some clinical aspects of Cystisosporafelis (Wenyon, 1926) Frenkel, 1976 (Apicomplexa: Cystiososporinae) experimentally infected in cats. Arquivos da Universidade Federal Rural do Rio de Janeiro 15,79-84 MATSUI, T., ITO, S., FUJINO, T. & MORII, T. (1993) Infectivity and sporogony of Caryospora-type oocysts of Isospora rivolta obtained by heating. Parasitology Research 79, 599-206 ROMMEL, M., SCHNIEDER, T., KRAUSSE, H. D. & WESTERHOFF, J. (1987) Trials to suppress the formation of oocysts and cysts of Toxoplasma gondii in cats by medication of the feed with toltrazuril. Veterinary Medical Review 2,141-153

The Levels of Blood Lead and Cadmium in Urban and Rural Population in Korea

The purpose of this study was to evaluate the levels of blood lead and cadmium in urban and rural populations. Blood samples were collected from 100 urban (Busan) residents and 150 rural residents (Jinju-84, Gijang-66) from July 1 to August 30, 2007. The blood lead and cadmium levels were analyzed using flameless atomic absorption spectrophotometry and were compared by age, gender and smoking status. The mean levels of blood lead in urban-Busan, rural-Jinju and rural-Gijang residents were , and , respectively. There was a significant difference in the level of blood lead between urban-Busan residents and rural-Gijang residents. The mean levels of blood cadmium in urban-Busan, rural-Jinju and rural-Gijang residents were , and , respectively. There was a significant difference in the level of blood cadmium between urban-Busan residents and rural-Jinju residents. This study showed that the levels of blood lead and cadmium were significantly different between urban and rural populations. The level of blood lead was highest in urban-Busan residents, but the level of blood cadmium was highest in rural-Jinju residents. Further studies are needed to define the cause of high levels of blood lead and cadmium related to area of residence and personal habits.

A Comparative Study of the Epidemiological Aspects of Legionnaires’ Disease: Outbreaks in Korea and Japan, 2010 - 2014

Background In the present study, we compared the epidemiological aspects of Legionnaire’ disease (LD) outbreaks in Korea and Japan by analyzing the current state from 2010 to 2014. Methods The following factors were analyzed: nationwide cumulative incidence rate (CIR) per 100,000 populations and case-fatality rate in percentage, epidemiological aspects (i.e., case related to gender), male to female morbidity ratio (MFMR), age, seasonality and habitat distribution of LD cases. Results In total, there were 134 cases of LD with the CIR of 0.05 per 100,000 populations in Korea from 2010 to 2014. During the same period in Japan, there were 4,840 cases of LD with a CIR of 0.76 per 100,000 populations. The CIR in Japan was significantly higher than that in Korea. However, the case-fatality rates were at similar levels (3.0% vs. 5.9%). Moreover, LD affects both sexes differently, accounting for 2.05 and 4.41 of MFMR in Korea and Japan, respectively. In both countries, the incidence mainly occurred among people aged 40 years or older, and peaked in summer (37.3% vs. 33.7% of total cases). Significant differences were observed in the incidence of LD cases between the capital city and county areas in both two countries. These differences in LD risk factors reflect the different influences of reservoir/host with natural or artificial aquatic environments. Conclusion This study provides a quantitative analysis of the epidemiological aspects and risk factors of LD outbreaks in Korea and Japan. We hope this study would be helpful for providing insight on effective future strategies to reduce LD outbreaks.

Comparative study on the epidemiological trends and aspects of murine typhus in Korea in the last decade (2006–2015)

Introduction: In this study, we undertook a retrospective analysis of the epidemiological aspects and risk factors of murine typhus (MT) in Korea in the last decade (2006–2015). Materials and Methods: MT infections in Korea using a total of 411 cases obtained from the Diseases Web Statistical System of the Korea Center for Disease Control and Prevention. Results: In a total of 411 MT infection cases, the cumulative incidence rate was 0.08/100,000 populations. Men were slightly more infected by MT as compared to women (51.3% vs. 48.7%), and a higher incidence of MT was observed in people aged over 40 years (93.4%; P < 0.01). The seasonal pattern of outbreaks revealed that most infections occurred from October to November (69.1% of the total cases) (P < 0.01). Significantly more outbreaks occurred in the southern part (53.5%) of the Korean peninsula as compared to its northern (33.3%) and central (10.7%) parts, as well as the Jeju Island (1.0%) (P < 0.01). In addition, the number of MT infections was significantly higher in rural and sea-village (87.6%) than in urban areas (12.4%; P < 0.01). Conclusion: In conclusion, the rapid reemergence of MT outbreaks can be minimized through health education, and a strong enforcement of control measures against rats and their ectoparasites could markedly reduce the transmission of this infection to humans in high-risk areas.