Myron R. Melamed

Early incidence rates of precancerous cervical lesions in women using contraceptives

Abstract This report describes the continuation of a study on the occurrence of early cervical neoplasia in relation to method of contraception used by women attending Planned Parenthood of New York City, Inc. An earlier paper indicated a small but significant excess in prevalence rates of carcinoma in situ for steroid users compared with diaphragm users. We now estimate incidence rates of carcinoma in situ and lesser precancerous cervical lesions in steroid, diaphragm, and IUD contraceptors who are initially proved free of cervical neoplasia. These data do not prove any statistically significant differences although the estimates exhibit variations not inconsistent with our previous findings.

Automated flow cytometry to monitor intravesical BCG therapy of superficial bladder cancer

The automated flow cytometry system (FCM) at Memorial Sloan-Kettering Cancer Center has been used to monitor the effect of intravesical BCG in the therapy of superficial bladder cancer. Analysis of saline bladder washings prior to therapy, weekly during the six weeks of therapy, and at follow-up examination in 2 patients, 1 responder and 1 nonresponder, provides the basis for some projections regarding the potential value of this technique.