N. Cerullo

Spectrum shaping assessment of accelerator-based fusion neutron sources to be used in BNCT treatment

Abstract Monte Carlo modelling of an irradiation facility, for boron neutron capture therapy (BNCT) application, using a set of advanced type, accelerator based, 3 H(d,n) 4 He (D–T) fusion neutron source device is presented. Some general issues concerning the design of a proper irradiation beam shaping assembly, based on very hard energy neutron source spectrum, are reviewed. The facility here proposed, which represents an interesting solution compared to the much more investigated Li or Be based accelerator driven neutron source could fulfil all the medical and safety requirements to be used by an hospital environment.

Spectrum shaping of accelerator-based neutron beams for BNCT

We describe Monte Carlo simulations of three facilities for the production of epithermal neutrons for Boron Neutron Capture Therapy (BNCT) and examine general aspects and problems of designing the spectrum-shaping assemblies to be used with these neutron sources. The first facility is based on an accelerator-driven low-power subcritical reactor, operating as a neutron amplifier. The other two facilities have no amplifier and rely entirely on their primary sources, a D-T fusion reaction device and a conventional 2.5 MeV proton accelerator with a Li target, respectively.

Progress in the use of gadolinium for NCT

The evaluation of possible improvement in the use of Gd in cancer therapy, in reference to gadolinium in cancer therapy (GdNCT), has been analysed. At first the problem of the gadolinium compounds toxicity was reviewed identifying the Motexafin Gadolinium as the best. Afterwards, the spectrum of IC and Auger electrons was calculated using a special method. Afterwards, this electron source has been used as input of the PENELOPE code and the energy deposit in DNA was well defined. Taking into account that the electron yield and energy distribution are related to the neutron beam spectrum and intensity, the shaping assembly architecture was optimised through computational investigations. Finally the study of GdNCT was performed from two different points of view: macrodosimetry using MCNPX, with calculation of absorbed doses both in tumour and healthy tissues, and microdosimetry using PENELOPE, with the determination of electron RBE through the energy deposit. The equivalent doses were determined combining these two kinds of data, introducing specific figures of merit to be used in treatment planning system (TPS). According to these results, the GdNCT appears to be a fairly possible tumour therapy.

An irradiation facility for Boron Neutron Capture Therapy application based on a radio frequency driven D-T neutron source and a new beam shaping assembly

A line of the Boron Neutron Capture Therapy (BNCT) research program aimed at the treatment of brain tumors, carried on at the Nuclear Departments of Pisa and Genova Universities (DIMNP and DITEC), is being focused on a new, 3H(d,n)4He (D–T), accelerator-based neutron source concept, developed at Lawrence Berkeley National Laboratory (LBNL). Simple and compact accelerator designs, using mixed D+ T+ ion beam with relatively low energy, ∼100 keV, have been developed which, in turn, can generate high neutron yields. New approaches have thus been started to design an epithermal neutron irradiation facility able to selectively slow the 14.1 MeV D–T neutrons down to the epithermal (1 eV–10 KeV) energy range. New neutron spectrum shifter and filtering materials, as well as different facility layout approaches have been tested. Possible beam shaping assembly models have also been designed. The research demonstrates that a D–T neutron source could be successfully implemented to provide a ∼1×109 n/cm2 s epithermal n...

Generation IV reactor designs, operation and fuel cycle

This chapter looks at Generation IV nuclear reactors, such as the very high-temperature reactor (VHTR), the supercritical water reactor (SCWR), the molten salt reactor (MSR), the sodium-cooled fast reactor (SFR), the lead-cooled fast reactor (LFR) and the gas-cooled fast reactor (GFR). Reactor designs and fuel cycles are also described.

The use of Th in HTR: State of the art and implementation in Th/Pu fuel cycles

Nowadays nuclear is the only greenhouse-free source that can appreciably respond to the increasing worldwide energy demand. The use of Thorium in the nuclear energy production may offer some advantages to accomplish this task. Extensive R&D on the thorium fuel cycle has been conducted in many countries around the world. Starting from the current nuclear waste policy, the EU-PUMA project focuses on the potential benefits of using the HTR core as a Pu/MA transmuter. In this paper the following aspects have been analysed: (1) the state-of-the-art of the studies on the use of Th in different reactors, (2) the use of Th in HTRs, with a particular emphasis on Th-Pu fuel cycles, (3) an original assessment of Th-Pu fuel cycles in HTR. Some aspects related to Thorium exploitation were outlined, particularly its suitability for working in pebble-bed HTR in a Th-Pu fuel cycle. The influence of the Th/Pu weight fraction at BOC in a typical HTR pebble was analysed as far as the reactivity trend versus burn-up, the energy produced per Pu mass, and the Pu isotopic composition at EOC are concerned. Although deeper investigations need to be performed in order to draw final conclusions, it is possible to state that some optimized Th percentage in the initial Pu/Th fuel could be suggested on the basis of the aim we are trying to reach.

Preliminary Evaluation of a Nuclear Scenario Involving Innovative Gas Cooled Reactors

In order to guarantee a sustainable supply of future energy demand without compromising the environment, some actions for a substantial reduction of CO2 emissions are nowadays deeply analysed. One of them is the improvement of the nuclear energy use. In this framework, innovative gas-cooled reactors (both thermal and fast) seem to be very attractive from the electricity production point of view and for the potential industrial use along the high temperature processes (e.g., H2 production by steam reforming or I-S process). This work focuses on a preliminary (and conservative) evaluation of possible advantages that a symbiotic cycle (EPR-PBMR-GCFR) could entail, with special regard to the reduction of the HLW inventory and the optimization of the exploitation of the fuel resources. The comparison between the symbiotic cycle chosen and the reference one (once-through scenario, i.e., EPR-SNF directly disposed) shows a reduction of the time needed to reach a fixed reference level from ∼170000 years to ∼1550 years (comparable with typical human times and for this reason more acceptable by the public opinion). In addition, this cycle enables to have a more efficient use of resources involved: the total electric energy produced becomes equal to ∼630 TWh/year (instead of only ∼530 TWh/year using only EPR) without consuming additional raw materials.

Assessment of LWR-HTR-GCFR Integrated Cycle

Preliminary analyses already performed showed that innovative GCRs, both thermal and fast, are very promising candidate to reach the Gen-IV sustainability goal. The integrated LWR-HTR-GCFR basically aims at closing the current nuclear fuel cycle: in principle, thanks to the unique characteristics of Helium coolant reactors, LWR SNF along with DU become valuable material to produce energy. Additionally, burning HMs of LWR SNF means not only a drastic reduction in the Unat demand but also a remarkable decrease in the long-term radiotoxic component of nuclear waste to be geologically stored. This paper focuses on the analyses of the LWR-HTR-GCFR cycle performed by the University of Pisa in the frame of the EU PUMA project (6th FP). Starting from a brief outline of the main characteristics of HTR and GCFR concepts and of the advantages of linking LWR, HTR and GCFR in a symbiotic way, this paper shows the integrated cycle involving a typical LWR (1000 MWe), a PBMR (400 MWth) and a GCFR-“E” (2400 MWth). Additionally, a brief overview of the main technological constraints concerning (Pu

Development of a treatment planning system for BNCT based on positron emission tomography data: preliminary results

Abstract Present standard treatment planning (TP) for glioblastoma multiforme (GBM – a kind of brain tumor), used in all boron neutron capture therapy (BNCT) trials, requires the construction (based on CT and/or MRI images) of a 3D model of the patient head, in which several regions, corresponding to different anatomical structures, are identified. The model is then employed by a computer code to simulate radiation transport in human tissues. The assumption is always made that considering a single value of boron concentration for each specific region will not lead to significant errors in dose computation. The concentration values are estimated “indirectly”, on the basis of previous experience and blood sample analysis. This paper describes an original approach, with the introduction of data on the in vivo boron distribution, acquired by a positron emission tomography (PET) scan after labeling the BPA (borono-phenylalanine) with the positron emitter 18F. The feasibility of this approach was first tested with good results using the code CARONTE. Now a complete TPS is under development. The main features of the first version of this code are described and the results of a preliminary study are presented. Significant differences in dose computation arise when the two different approaches (“standard” and “PET-based”) are applied to the TP of the same GBM case.

Analysis of Pebble-Fueled Zone Modeling Influence on High-Temperature Reactor Core Calculations

Abstract The pebble bed gas-cooled reactor is one of the most promising concepts among the Generation III+ and Generation IV reactors. Currently, the pebble bed modular reactor (PBMR) design, both U and Pu and minor actinide fueled, is being developed. Modeling the arrangement of coated particles (CPs) inside a spherical region like a pebble seems to be an important issue in the frame of calculations. To use the (relatively) old Monte Carlo codes without any correction, some approximations are often introduced. Recent Monte Carlo codes like MCNP5 and some new original subroutines that we have developed allow the possibility of obtaining more detailed and more physically correct geometrical descriptions of this kind of system. Some studies on modeling pebbles and pebble bed cores have already been carried out by other researchers, but these works are substantially limited to AVR-type UO2-fueled pebbles. However, the impact of approximated models on fuel mass, reactivity, and reactor life prediction has not yet been investigated for new PBMR-type pebbles. At the same time, an assessment of introducing a stochastic CP arrangement is not so widespread. Analyzing two PBMR pebbles, one Pu- and the other U-fueled, this paper focuses on quantifying errors due to the different approximations generally used to describe the CP lattice inside a high-temperature reactor pebble bed core, as far as mass of fuel, reactivity, and burnup simulation are concerned. This aim was reached also through a new feature implemented in the MCNP5 code, i.e., capability to treat (pseudo) stochastic geometries. Later, we compared the initial mass of fuel, keff, and isotopic evolution versus burnup of some approximated pebble models with the reference model, built by means of this new MCNP5 feature.