N. F. Lazareva

(N-methyl-N-alkoxymethylaminomethyl)dialkoxysilanes and bis[N-methyl-N-(dialkoxysilylmethyl)amino]methanes

Abstract(N-methyl-N-alkoxymethylaminomethyl)-dialkoxysilanes and bis[N-methyl-N-(dialkoxymethyl)amino]methanes were first obtained by the interaction of (N-methylaminomethyl) dialkoxy-R-silanes with chloromethyl alkyl ethers in yields of 40–67% and 10–25 %, respectively.

Reactions of 1-hydro-and 1-halosilatranes with metal salts

Abstract1-Hydrosilatrane reduces AgNO3 and CuCl2 in CH3CN to form metallic silver and CuCl, respectively; other reaction products are the silatranyl nitrate O2NOSi(OCH2CH2)3N and the 1-chlorosilatrane ClSi(OCH2CH2)3N.

Si-C-Bond cleavage in 1-organylsilatranes by bromine or iodine chloride

The Si-C bond in I-organylsilatranes is cleaved by bromine or iodine chloride to yield 1-bromo- or 1-chlorosilatrane respectively. In the presence of Et2O or THF and under the action of dioxane dibromide, I-halosilatrane

Synthesis and structure of potentially biologically active N-(silylmethyl)tetrahydropyrimidin-2-ones

A transsilylation of 1,3-bis(trimethylsilyl)tetrahydropyrimidin-2-one with (chloromethyl)-chlorosilanes ClCH2SiMenCl3–n (n = 0, 2) gave the corresponding 1,3-bis[(chlorosilyl)-methyl]tetrahydropyrimidin-2-ones. New Si-containing tetrahydropyrimidin-2-ones were synthesized by the exchange reactions at the Si—Cl and Si—N bonds of these compounds. The structures of all the synthesized compounds were confirmed by multinuclear NMR spectroscopy. Virtual screening using the PASS program showed that these compounds can exhibit certain types of biological activity with 40—94% probability.

N-(2-THENYL)DERIVATIVES OF AMINOALKYLTRIETHOXYSILANES,-SILATRANES AND 2,2-DIMETHYL-1,3-DIOXA-6-AZA-SILACYCLOOCTANE

The reactions of aminoalkylethoxysilanes and 2,2-dimethyl-1,3-dioxa-6-aza-2-silacyclooctane with 2-(chlormethyl)thiophene and its 5-chloroderivative lead to the correspondingN-(2-thenyl) derivatives. TheN-methyl-N-(2-thenyl)aminomethyltriethoxysilane and 5-chlorothyenyl derivative formed are converted by triethanolamine into silatranes.

1-organyl-3-(2-vinyloxyethoxymethyl)silatranes

ConclusionsThe reaction of N-[2-hydroxy-2-(2-vinyloxyethoxymethyl)ethyl]-bis(2-hydroxyethyl)amine with organyltriethoxysilanes at 20–40°C gave previously unreported 1-organyl-3-(2-vinyloxy-ethoxymethy)silatranes, (R=CH3, ClCH2, CH2=CH, C6H5, C2H5O).

Synthesis of [(N-acetyl-N-methyl)aminomethyl](dimethyl)silyl nitrate

Transsilylation of N-methyl-N-trimethylsilylacetamide with chloromethyl(dimethyl)silylnitrate ClCH2SiMe2ONO2 led to the formation of (N-acetyl-N-methyl)aminomethyl](dimethyl)silyl nitrate, the (O–Si)-chelate with the intramolecular coordination C=O→Si bond. Spectral characteristics of this compound and the reaction product of N-[chloro(dimethyl)silylmethyl]-N-methylacetamide with silver nitrate are identical.

N-methyI-N-(triethoxysilylmethyl) andN-methyl-N-(silatran-1-ylmethyl) substituted glycine and alanine

Organosilicon derivatives of glycine, α- and β-alanine, and α-methylalanine were prepared by the reaction of methyl esters of α- and β-halocarboxylic acids withN-methylaminomethyltriethoxysilane in the presence of triethylamine. The compounds synthesized were converted into the correspondingN-silatran-l-ylmethyl derivatives. Trimethylsilyliodoacetate reacts withN-methylaminomethyltrietoxysilane to give 2,2-diethoxy4-methyl-1-oxa-4-aza-2-silacyclohexane-6-one. Its reaction with triethanolamine leads toN-methyl-N-(silatran-l-ylmethyl)glycine.