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Featured researches published by N. Graillon.


Revue de Stomatologie, de Chirurgie Maxillo-faciale et de Chirurgie Orale | 2016

Orofacial manifestations of scleroderma. A literature review.

M. Hadj Saïd; J.M. Foletti; N. Graillon; L. Guyot; C. Chossegros

INTRODUCTIONnScleroderma is a rare disease of the connective tissue (50 to 200 patients/1 million people; 60,000 patients in France). We conducted a literature review about the orofacial manifestations of scleroderma that have been little studied.nnnMATERIAL AND METHODSnThe 45 articles found in 6 different databases by using the keywords scleroderma, systemic sclerosis, oral medicine, face and published between 1944 and 2016 were selected, for a total of 328 patients.nnnRESULTSnA total of 1187 orofacial manifestations of scleroderma were identified, occurring mainly in women (84.5%) with a mean age of 40.2 years, 10 years on average after the first manifestation of the disease. The main ones were limitation of mouth opening (69.8%), widening of the periodontal ligament (67.3%), xerostomia (63.4%), telangiectasia (36.2%) and bone lesions (34.5%). Dental root resorptions, pulp and nose calcifications were also reported but with no evident link with scleroderma.nnnDISCUSSIONnOrofacial manifestations of scleroderma are probably more common than reported. They mostly affect women with a mean age of 40. The most common oral manifestations are limitation of mouth opening, widening of the periodontal ligament and xerostomia. Because of the handicap they may be responsible for, these manifestations must be detected early in order to prevent from functional impairments and from dental and periodontal lesions.


Journal of Oral and Maxillofacial Surgery | 2018

Salivary Calculi Removal by Minimally Invasive Techniques: A Decision Tree Based on the Diameter of the Calculi and Their Position in the Excretory Duct

Jean Marc Foletti; N. Graillon; Simon Avignon; L. Guyot; C. Chossegros

PURPOSEnTo suggest a decision tree for the choice of the best minimally invasive technique to treat submandibular and parotid calculi, according to the diameter of the calculi and their position in the excretory duct.nnnMATERIALS AND METHODSnSubmandibular and parotid ducts can both be divided into thirds, delineated by easily recognizable landmarks. The diameter of calculi is schematically classified into 1 of these 3 categories: floating, slightly impacted, or largely impacted.nnnRESULTSnUsing 3 criteria, the type of gland involved (G), the topography (T) of the calculus and its diameter (D), a 3-stage GTD classification of calculi was established. Next, the best indication for each available minimally invasive technique (sialendoscopy, transmucosal approach, a combined approach, intra- or extracorporeal stone fragmentation) was determined for each calculus stage.nnnCONCLUSIONSnThe minimally invasive treatment options are numerous and have replaced invasive resection surgical approaches (submandibulectomy and parotidectomy) in the management of salivary calculi, significantly improving the prognosis of these diseases. We emphasize the need for flexibility in the surgical indications and challenge the dogma of all endoscopic management of salivary calculi.


Revue de Stomatologie, de Chirurgie Maxillo-faciale et de Chirurgie Orale | 2016

Carcinomes intra-osseux primitifs des mâchoires de novo (type 3)

A.C. Ray; J.M. Foletti; N. Graillon; L. Guyot; C. Chossegros

INTRODUCTIONnPrimary intraosseous carcinoma (PIOC) of the jaws is a rare epidermoid carcinoma from epithelial origin and initially strictly localized within the bone. Histologically, type 3 PIOC (PIOC3) is a de novo primary intraosseous carcinoma. Because of the rarity of this illness, we propose an analysis of a personal case and a revue of the literature.nnnMATERIAL AND METHODSnTwo search engines (Pubmed®, Sciencedirect®) were questioned over the period 1976-February 2016 by using following keywords carcinoma, intraosseous, jaws, squamous cell carcinoma. Articles reporting proven PIOC3 and mentioning a precise treatment were selected.nnnRESULTSnThirty articles concerning 54 patients (sex ratio: 2.4; mean age: 56.8; extreme: 24-78) met the inclusion criterions. The most common symptoms were swelling (53%), pain (44.9%) and infra-alveolar nerve paresthesia (30.6%). The time to diagnosis was 13 weeks. Classification of Zwetyenga et al. showed more than 80% of T2 and T3 stages. The lesions were predominantly mandibular (85.2%) and posterior. Less than a third of patients had lymph node and 10% had distant metastasis. Treatment consisted mostly in a combination of surgery and radiotherapy. With a mean follow-up of 74.8 months, 70.8% were in remission with no evidence of recurrence. We report the case of a 58-year-old patient, with no medical history, complaining since several months about periodontitis with teeth mobility in the right mandibular area. The panoramic X-ray showed a bone lysis at the place of tooth No.xa046. In the absence of alveolar healing after extraction and antibiotherapy, a biopsy was made that diagnosed a differentiated keratinizing squamous cell carcinoma. CT scan and MRI showed a mandibular cortical bone loss with involvement of adjacent structures and lymphadenopathy in the ipsilateral IB area. The patient was treated with a combination of chemotherapy and surgery. Postoperative chemo- and radiotherapy is still going on.nnnDISCUSSIONnThe PIOC3 is a rare tumor, mainly arising in males around 50. Diagnosis should be evoked in the presence of painful swelling and nervous symptoms. The time to diagnosis is long. Tumors are usually seen at late stages. Treatment classically combines surgery and radiotherapy.


Journal of Stomatology, Oral and Maxillofacial Surgery | 2018

Extracorporeal lithotripsy of salivary gland stone: A 55 patients study

J. Lafont; N. Graillon; M. Hadj Saïd; D. Tardivo; J.M. Foletti; C. Chossegros

Sialolithiasis are the most frequent salivary gland disease, mainly affecting the submandibular gland. With the advent of minimally invasive techniques, total salivary gland removal should not be considered as the first-line treatment anymore. Extracorporeal Shock Wave Lithotripsy (ESWL) is an alternative to surgery preserving the gland. The objective of our retrospective study was to evaluate the efficiency of ESWL on pain and obstructive syndrome in patients suffering from sialolithiasis. The global result felt by the patients was also considered. All patients treated between October 2009 and July 2016 for sialolithiasis by ESWL in our department were included. They were divided into two groups according to the concerned gland: a parotid gland (PG) and a submandibular gland (SMG) group. Our retrospective telephone questionnaire consisted in 4 questions about their symptomatology before and after ESWL, including pain self-evaluation before and after treatment. They were finally asked to evaluate the global result of the ESWL treatment: excellent, good, mean, or poor. In total, 55 patients were included in this study, 38 patients in PG group and 17 patients in SMG group. We observed a decrease of pain and obstructive syndrom after ESWL procedure in both groups. Better results were found on the obstructive syndrome in the PG group. Very few side-effects were reported by patients. Given that it has very few side effects, ESWL can easily be considered as first line treatment for sialolithiasis to avoid heavier treatments such as surgery. It should be the first-line treatment for symptomatic parotid sialolithiases. The treatment of symptomatic submandibular sialolithiases depends on the topography of the lithiasis.


Journal of Stomatology, Oral and Maxillofacial Surgery | 2018

Retrograde approach for parotid benign tumours: A review

J. Gagé; C. Chossegros; P. Haen; L. Guyot; A. Gallucci; N. Graillon

INTRODUCTIONnParotidectomy for benign tumours is usually performed after facial nerve trunk discovery through an anterograde approach (AA) of the nerve. More recently, a retrograde approach (RA) toward the facial nerve, which begins on the facial nerve branches and ends on the nerve trunk, has been described. A literature review of the RA was conducted to evaluate the RA and to compare it with AA.nnnMETHODSnA literature review was conducted for the years 1980 through 2016. Nine studies out of 216 were included, including 558 parotidectomies and 370 RA. We studied the operative time (OT), the postoperative complications including facial paralysis (FP), tumour recurrences, and possibilities for reoperation.nnnRESULTSnOperative time was shorter in RA than in AA. Transitory FP significantly less frequent in RA than in AA in only one studies and not significantly in four studies. Incidence of Frey syndrome was similar in RA and AA. Tumour relapses were reported in 1.8% of cases with RA, comparable to AA.nnnCONCLUSIONnRetrograde parotidectomy is recommendable. OT was significantly shorter for the RA. The FP rate was lower for RA than for AA, but the difference was not significant. The recurrence rate appeared to be similar between RA and AA. Possibilities of reoperation were better after RA.


Journal of Cranio-maxillofacial Surgery | 2018

Bioactive glass 45S5 ceramic for alveolar cleft reconstruction, about 58 cases

N. Graillon; Nathalie Degardin; Jean Marc Foletti; Magali Seiler; Marine Alessandrini; A. Gallucci

BACKGROUNDnSecondary alveolar bone grafting in patients with clefts lip and palate is usually performed with iliac crest bone harvesting, however using bone substitute allow to avoid harvesting morbidity. The purpose of our study was to assess if the use of a bioactive glass ceramic is an acceptable alternative to iliac crest bone harvesting in alveolar clefts treatment.nnnMETHODSnA prospective study including all patients who have benefited of alveolar grafting by GlassBONE™ (Noraker, France), a synthetic resorbable bioactive glass 45S5 ceramic was conducted. The patients underwent clinical assessments and imaging check-up by dental panoramic radiography and CBCT.nnnRESULTSnFifty-eight graftings were performed. The mean age at the time of the graft was 7.6 years. Hospitalization, social eviction and antalgic consumption were reduced. Bone continuity was achieved in 63.8% of the cases. Bilateral cleft and dental agenesia increased grafting failure. In the subgroup of 25 patients with isolated unilateral cleft without dental agenesis, 80% had bone continuity at one year. We noted 10.3% of alveolar fistula recurrence.nnnCONCLUSIONnThe use of GlassBONE™ in alveolar grafts simplifies the surgery procedure and the postoperative management, and ensures satisfactory mucosal healing, tooth eruption and bone continuity in two thirds of the followed grafts.


Journal of Stomatology, Oral and Maxillofacial Surgery | 2017

Double palatal flap for oro-nasal fistula closure

P. Pouzoulet; N. Graillon; L. Guyot; C. Chossegros; J.M. Foletti

INTRODUCTIONnThe management of oral fistula to the nose depends on its etiology, its size and its location. Here, we describe a simple technique, inspired by the ones initially developed by Bardach for cleft palates repair. The surgical alternatives are discussed.nnnTECHNICAL NOTEnThe double palatal flap is a simple technique, allowing closure in a single session of a central or centro-lateral palate fistula. The key of this technique is the dissection between nasal and palate mucous layers, providing a sufficient amount of laxity to close the defect without tension.nnnDISCUSSIONnThe double palatal flap can cover centro-lateral palate mucosal fistulae. It provides both aesthetic and functional results in a single stage. Reliability, simplicity and quickness are its main advantages. Outcomes are usually simple; Velar insufficiency may occur, that can be corrected by speech therapy.


Journal of Stomatology, Oral and Maxillofacial Surgery | 2017

CT scan assessment in salivary gland lithiasis diagnosis

M.A. Gardon; J.M. Foletti; S. Avignon; N. Graillon; C. Chossegros

INTRODUCTIONnThe aim of the study was to assess computed tomography (CT) scan efficiency for the diagnosis of salivary lithiasis.nnnMETHODSnPatients who were included were all the patients who consulted in our department for main salivary gland (submandibular and parotid) obstruction symptoms between June 2014 and December 2016. A CT scan without injection was prescribed for all of them. The 163 patients were divided into two groups after the CT scan: patients with and without lithiasis. During surgery, we confirmed the presence or absence of the lithiasis previously diagnosed on the CT scan. The patients were divided in two groups: case and control groups. For statistical analysis, the sensitivity, specificity, and the negative and positive predictive values of the preoperative CT scan were calculated.nnnRESULTSnA total of 163 patients with a salivary obstructive syndrome were included. On the CT scans, we found lithiases (hyperdense images) in 157 glands (CT scan⊕ group), and we found no lithiasis in 6 glands (CT scan group). In the CT scan⊕ group, 203 lithiases were present. During surgery, we found and removed lithiases in 155 patients (case group), and 8 patients had no lithiases (control group). The overall sensitivity, specificity, positive predictive value, and negative predictive values of the CT scan for the detection of lithiasis were 100%, 75%, 99%, and 100%, respectively. The specificity of CT scans for the lithiasis located in the anterior and middle third of the duct was 100%.nnnDISCUSSIONnAccording to our study, the CT scan is very efficient in diagnosing salivary main gland lithiases in patients with an obstructive syndrome.


Revue de Stomatologie, de Chirurgie Maxillo-faciale et de Chirurgie Orale | 2016

Les Torus ou Torii de la cavité buccale, pourquoi ?

C. Chossegros; J.M. Foletti; N. Graillon; L. Guyot

a Service de chirurgie maxillofaciale, stomatologie et chirurgie orale, hôpital de la Conception, CHU de Marseille, 147, boulevard Baille, 13385 Marseille cedex 5, France b Service de chirurgie maxillofaciale, chirurgie plastique, stomatologie, hôpital Nord, chemin des Bourrelys, 13015 Marseille, France c Aix-Marseille université, Jardin du Pharo, 58, boulevard Charles-Livon, 13284 Marseille cedex 07, France d UMR 6057, laboratoire parole et langage (LPL), 5, boulevard Pasteur, 13100 Aix-en-Provence, France Disponible en ligne sur


Revue de Stomatologie, de Chirurgie Maxillo-faciale et de Chirurgie Orale | 2016

Une inflammation palatine inexpliquée

I. Romanet; J.M. Foletti; E. Massereau; N. Graillon; C. Chossegros

Une patiente de 24 ans, sans antécédent particulier, a consulté pour des douleurs au niveau du palais et des gencives. À l’interrogatoire, elle se plaignait de douleurs inconstantes au niveau gingival et d’une gêne au niveau palatin soulagée par des antalgiques de palier 1, type paracétamol. L’examen général retrouvait une asthénie évoluant depuis quelques mois associée à des arthralgies aspécifiques localisées au niveau des mains évoluant de façon paroxystique.

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C. Chossegros

Aix-Marseille University

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J.M. Foletti

Aix-Marseille University

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L. Guyot

Aix-Marseille University

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A. Gallucci

Aix-Marseille University

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M. Hadj Saïd

Aix-Marseille University

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A.C. Ray

Aix-Marseille University

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D. Tardivo

Aix-Marseille University

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J. Lafont

Aix-Marseille University

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M.A. Gardon

Aix-Marseille University

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