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Featured researches published by N. I. Baram.
Chemistry of Natural Compounds | 1997
Kh. L. Ziyaev; F. G. Kamaev; N. I. Baram; L. Biktimirov; A. I. Ismailov
Information is given on new gossypol imines. The use of hydrazines as the imine components produces Schiff bases of gossypol existing in the benzoid form.
Chemistry of Natural Compounds | 2000
N. I. Baram; Kh. L. Ziyaev; A. I. Ismailov; D. Ziyamov; Yu. S. Mangutova
Compound mp, (C R * UV spectrum, , nm (log J) Empirical formula Yield, % f max 1 205-207 0.61 330(4.10) C H N O 71.70 2 315-317 0.80 345(4.02) C H N O S Na 68.10 3 152-154 0.55 440(4.15) C H N O 58.84 4 254-256 0.54 505(4.41) C H N O 69.12 5 283-285 0.85 485(4.12) C H N O 74.71 6 248-250 0.71 490(4.75) C H N O S 48.17 7 275-277 0.65 470(4.80) C H N O S 54.08 8 248-250 0.82 460(4.82) CH N O S 53.13 9 277-278 0.80 460(4.54) CH N O S 64.15 10 298-300 0.78 450(4.58) CH N O S 67.84 11 235-237 0.74 460(4.74) CH N O S 74.1 12 224-226 0.64 455(4.42) CH N O S 70.0 13 215-218 0.62 485(4.54) CH N O S 44.1 14 279-281 0.80 380(4.73) C H N O 56.6 34 38 4 10 34 36 4 16 2 2 42 38 4 8 54 46 8 8 58 54 8 8 42 40 6 12 2 44 48 8 12 4 48 48 10 12 2 50 44 10 12 2 52 48 10 14 2 50 48 10 14 2 52 48 10 14 2 54 52 10 12 2 52 50 8 10 ______ *Acetone—toluene (6:4)
Chemistry of Natural Compounds | 1988
N. I. Baram; Kh. L. Ziyaev; G. A. Ismailova; L. Biktimirov; A. I. Ismailov; K. G. Urazmetov
Information is given on the immunosuppressive activity of a number of gossypol derivatives, and it is shown that practically all the compounds studied are immunotropic. The structural-functional relationship and the dose-dependent nature of the action of the substances obtained are shown.
Chemistry of Natural Compounds | 1991
N. I. Baram; L. Biktimirov; S. B. Dzhurabekova; F. G. Kamaev; A. I. Ismailov
Imines of methyl ethers of gossypol have been synthesized for the first time, their structures have been shown, and their immunomodulating activities have been determined. The quinoid form of existence of the imines of the dimethyl ether and the benzoid form of the imine of the mexamethyl ether of gossypol have been shown.
Chemistry of Natural Compounds | 1999
V. N. Sumin; A. D. Sakhibov; N. I. Baram; A. I. Ismailov
Samples of batriden (a drug based on gossypol) radioactively labeled with14C in different parts of the molecule have been synthesized. Pharmacokinetic investigations of the14C-batridens have enabled the mechanism of the action of the drug to be elucidated.
Chemistry of Natural Compounds | 1996
L. Biktimirov; Kh. L. Ziyaev; B. Khodzhaniyazov; D. Ziyamov; N. I. Baram; A. I. Ismailov
The results are given of a comparative spectroscopic study of some gossypol derivatives and their complexes with N-polyvinylpyrrolidone.
Chemistry of Natural Compounds | 1996
N. I. Baram; L. Biktimirov; Kh. L. Ziyaev; R. Z. Paizieva; A. I. Ismailov
Information is given on the antiviral and interferon-inducing activities of gossypol and its derivatives.
Chemistry of Natural Compounds | 1999
N. I. Baram; Kh. L. Ziyaev; B. Khodzhaniyazov; A. I. Ismailov
The results are given of a study of the hydrolysis of alkyl- and heterylimines of gossypol at various pH values.
Chemistry of Natural Compounds | 1976
N. I. Baram; A. I. Ismailov; F. G. Kamaev; V. B. Leont'ev
SummaryIt has been shown on the basis of the results of a study of PMR spectra that, regardless of its source and method of purification, in weakly polar solvents gossypol exists predominantly in the aldehyde form.
Chemistry of Natural Compounds | 1998
Kh. L. Ziyaev; N. I. Baram; B. Khodzhaniyazov; F. G. Kamaev; L. Biktimirov; S. B. Dzhurabekova; A. I. Ismailov
The results are given of a study of gossypol, its physiologically active derivatives, and their complexes with N-polyvinylpyrrolidone (M.m. 8000) in various media. It has been shown that the production of complexes permits the creation not only of water-soluble forms but also of more stable forms of the compounds.
