N.J. Liebsch

136 Skull base chordomas: Treatment outcome and prognostic factors in adult patients following conformal treatment with 3d planning and high dose fractionated combined proton and photon radiation therapy

Methods & Materials: From 1975 through 1993, 132 adult patienls with skull base chordomas were treated with fractionated combined proton and photon radiation therapy. Seventy five patients (57%) were mate and 57 (43%) female. Age ranged from 19 to 80 years (median 45.5 years). All pathology was verified at MGH by a single pathologist Ninety six had non-chondroid (NCC) and 36 chondroid chordomas (CC), respectively. Median prescribed dose was 68.7 CGE (CGE, Cobalt Gray-equivalent: proton Gy X RBE 1.1 + photon Gy), ranging from 36 to 79.2 CGE; 95% received >_ 66.6 CGE. Between 70 and 100% of the close was given with the 160 MeV proton beam at the Harvard Cyclotron. 3D CT-based treatment planning has been employed in all patients treated since 1980. Median follow-up was 46 months (range 2-158 months).

Risk of sinonasal-cutaneous fistula after treatment for advanced sinonasal cancer†

To determine the rate and the risk factors for sinonasal‐cutaneous fistula formation after treatment for sinonasal malignancy.