N. Landa

Allergic contact dermatitis from Kathon 893

ing in an additional medicament series. We have not tried to validate the relationship between ketoconazole cream and sodium sulfite sensitivity by use testing. From our data, it can be concluded that the majority of patients sensitized to sodium sulfite have no known previous contact with ketoconazole cream or sodium-sulfite-containing topical preparations. The clinical relevance of the positive reactions to sodium sulfite remains to be established. Contact Dermatitis 1992: 27: 345

Generalized hypertrichosis after treatment with topical minoxidil

Generalized hypertrichosis is a common side‐effect of oral minoxidil treatment for hypertension. However, hypertrichosis is uncommon after treatment with topical minoxidil for alopecia, and normally only occurs in areas close to the side of application. A 16‐year‐old girl is presented who developed generalized hypertrichosis 3 months ater applying topical minoxidil for treatment of diffuse alopecia in doses greater than that prescribed. Four months after discontinuing treatment, the abnormal hair gradually diminished and disappeared.

Contact dermatitis from a moisturizing cream

nickel sulphate 36 43 43 thimerosal 10 14 16 K dichromate 10 II 13 PPD 11 12 12 fragrance mix 5 6 10 cobalt chloride 5 7 9 balsam of Peru 5 6 7 oleamidopropyldimethylamine 5 7 7 thiuram mix 6 6 6 p-amino-azobenz 5 5 6 PTBPF resin 3 4 5 amm. mercury 4 4 4 ethylenediamine 3 4 4 D-O-methane 3 4 4 Euxyl K 400 3 3 3 neomycin 0 3 3 German 115 2 2 2 wool alcohols 1 2 2 BHT I 1 2 epoxy resin 0 0 2 D. blue 124 2 2 2 D. red 1 I 1 1 D. yellow 3 1 1 1 D. orange 3 1 1 1 German II I I 1 Kathon CG I I I PPD mix I I 1 colophony I 1 1 benzocaine I 2 I mercapto 0 1 1

Positive patch tests to nigrosine

Nigrosine is a dye mixture prepared by heating (180– 200æ) nitrobenzene, aniline and aniline hydrochloride, in the presence of an iron or copper catalyst. It is virtually insoluble in water, slightly soluble in ethanol, benzene and toluene, and very soluble in stearic and oleic acids (1). Industrially, this blue-black solvent dye is used to color alcoholic solvents, varnishes, shoe polishes, lacquers, wood stains, marker-pencil inks, printing inks and spirit finishes for leather. It is also used as a sharkrepellent.