N.P. Gupta

Antibiotic prophylaxis for transrectal needle biopsy of the prostate: a randomized controlled study

Objectives To determine the effect of antibiotic prophylaxis on infective complications after transrectal needle biopsy of the prostate.

Severely encrusted polyurethane ureteral stents: Management and analysis of potential risk factors

OBJECTIVES To review the management of heavily encrusted and stuck JJ ureteral stents. We report our experience and review current published reports in managing heavily encrusted and stuck JJ stents, the guidelines for management, and the prevention of such problems. METHODS We reviewed our stent records from January 1994 to December 2000 and analyzed our stent complications and their final outcome. Fifteen patients had heavily encrusted and stuck stents. Of these, 14 were encountered in patients with a sizable stone burden (400 to 650 mm(2)) and 1 occurred in a patient with malignant ureteral obstruction. Sandwich combinations of multiple extracorporeal shock wave lithotripsy/traction and endourologic procedures were used to render them stone and stent free. The stent was examined and the encrustation was analyzed by x-ray crystallography. RESULTS Of 15 patients, 13 were available for evaluations; 1 patient was lost to follow-up and 1 patient died. The average stone burden was 625 mm(2). The encrustation was localized to the upper end in eight and to the lower and upper end in three. In 4 cases, the entire stent was encrusted, and the lumen was occluded in 12. All 13 patients with stuck, fragmented, and encrusted stents were rendered stone and stent free; 2 of the 13 had clinically insignificant residual stones (less than 2 mm). Calcium phosphate and monohydrate stones were the most commonly encountered stone encrustations. CONCLUSIONS Stent encrustation is one of the most serious complications of polyurethane JJ stents. Multimodal endourology should form the cornerstone of therapy for heavily encrusted stuck stents. It is important to maintain an efficient computerized stent log under the direct supervision of a physician. Patients with probable risk factors should be monitored even more frequently to avoid mishaps and morbidity.

Laparoscopic radical cystectomy with intracorporeal ileal conduit diversion: five cases with a 2-year follow-up.

Objective  To assess the feasibility and intermediate‐term outcome of laparoscopic radical cystectomy (LRC) with ileal conduit urinary diversion in patients with organ‐confined muscle‐invasive carcinoma of the urinary bladder, the entire procedure undertaken intracorporeally only using laparoscopic techniques.

Infundibulopelvic anatomy and clearance of inferior caliceal calculi with shock wave lithotripsy.

PURPOSE We evaluate the significance of inferior caliceal radiographic anatomy and determine its influence on successful fragmentation and clearance of inferior caliceal calculi with extracorporeal shock wave lithotripsy (ESWL). MATERIALS AND METHODS Between November 1996 and February 1998, 88 patients and 90 renal units with single or multiple inferior caliceal calculi of all sizes and composition were treated with ESWL. The size, number and area of calculi, length and width of the stone bearing inferior calix and infundibulopelvic angle were determined on pretreatment excretory urography. The infundibulopelvic angle was measured by 2 methods using the angle between the inferior caliceal infundibular and ureteral axes (angle 1), and between the infundibular and ureteropelvic axes (angle 2). Cases with residual fragments not clearing within 6 months of satisfactory fragmentation after lithotripsy were considered failures. RESULTS Overall stone clearance at 6 months was achieved in about 72% of the renal units. Infundibular length was 30 mm. or less in 77% of successful cases and in 64% of failures. Similarly, the smallest infundibular width of 5 mm. or more was found in 75% of successful cases compared to 41% of failures. Angle 1 of 35 degrees or more was observed in 73% of cases with compared to 18% without clearance. Angle 2 of 45 degrees or more was seen in 71% of successful cases compared to 9% of failures. The chances of a patient becoming stone-free with all favorable criteria of infundibular length 30 mm. or less, infundibular width 5 mm. or greater and infundibular ureteropelvic angle 45 degrees or greater was 100% (23 patients). CONCLUSIONS Radiographic features of a stone bearing inferior calix and its relation to the renal pelvis can be easily measured on standard excretory urography. An infundibular width of 5 mm. or more and infundibulopelvic angle 1 of 35 degrees or more or angle 2 of 45 degrees or more were statistically significant factors of radiographic anatomy in stone clearance following ESWL. Inferior caliceal length was not statistically significant, although length of 30 mm. or less appeared to be more favorable for stone clearance. The ideal treatment of inferior caliceal calculi in patients with all 3 favorable criteria is ESWL.

Cutaneous Metastases in Renal Cell Carcinoma

Cutaneous metastasis from renal cell carcinoma is believed to be rare. We present our experience with 10 (3.3%) cases seen in the last 12 years among 306 cases of renal adenocarcinoma treated at our center. There were 9 males and 1 female. Age ranged from 30 to 65 years (average 45 years). 5 patients had skin metastases at the time of presentation (stage IV). In one of them the skin nodule, rather than urologic symptoms, was the presenting complaint. 5 patients presented with skin metastasis during follow-up after nephrectomy. The average time to skin metastasis was 51 months for patients in stage I and 13 months in stage IIIb. The scalp was the most common site of metastasis followed by chest and abdomen. 90% of patients had secondaries in at least one other site, most commonly in lungs (4 cases) and bones (5 cases). 4 patients were treated with interferon-α 6 MIU, subcutaneously, three times a week for varying periods from 3 to 4 months but there was no response. In conclusion, cutaneous secondaries from RCC, though uncommon, are not very rare. A few patients may present with a skin mass before detection of the renal tumor. Patients with low-stage disease at presentation may also develop cutaneous secondaries, therefore a prolonged follow-up is required. The commonest site for cutaneous metastasis from RCC is the scalp and face. Most patients had at least one other site of systemic metastasis, hence they were not candidates for curative therapy. Interferon therapy was not helpful. Mean survival after detection of cutaneous metastasis was 7 months.

Evaluation of Laparoscopic Retroperitoneal Surgery in Urinary Stone Disease

PURPOSE To assess the safety and effectiveness of laparoscopic retroperitoneal surgery and attempt to define its role in the management of urolithiasis. PATIENTS AND METHODS Laparoscopic retroperitoneal surgery (LRS) was undertaken in 72 male and 42 female patients with calculous disease from March 1994 to April 2000 for variety of indications that otherwise would have made them candidates for conventional open surgery. Some of these patients were subjected to retroperitoneoscopic ureterolithotomy (RPUL) (40 patients) and retroperitoneoscopic pyelolithomy (RPPL) (7 patients). Retroperitoneoscopic nephrectomy (RPN) and nephroureterectomy (RPNUT) for a nonfunctioning renal unit secondary to renal and or ureteral calculi was done in 53 and 14 patients, respectively. Most of the procedures were performed with three 10-mm ports. In some cases, an additional 5-mm port was used. RESULTS The procedure was successful in 75%, 71%, 90.5%, and 86% of cases subjected to RPUL, RPPL, RPN, and RPNUT, respectively. The mean operating time for RPUL was 106.3 minutes and for RPPL was 108.2 minutes, whereas it was 99.7 minutes for RPN and 147 minutes for RPNUT of nonfunctioning kidneys secondary to calculous disease. The major complications encountered were colon injury in one patient with calculous pyonephrosis who had dense adhesions and injury to the external iliac artery in another patient having RPUL. The mean blood loss was 69.8, 127.2, 135.6, and 206.5 mL, respectively, for RPUL, RPPL, RPN, and RPNUT. The average hospital ranged from 3 to 4 days. CONCLUSIONS Laparoscopic retroperitoneal surgery has a definite role in the management of patients requiring open surgery for calculous disease. It is safe and feasible in spite of the dense adhesions that are frequently encountered in such patients. Often, previous attempts at treatment with shockwave lithotripsy or endourologic procedures also lead to inflammation and adhesions, making surgery difficult. However, these problems can be dealt with by LRS with good results.

POSTTRAUMATIC COMPLETE AND PARTIAL LOSS OF URETHRA WITH PELVIC FRACTURE IN GIRLS: AN APPRAISAL OF MANAGEMENT

PURPOSE Urethral injury in girls accompanying fracture of the pelvis is rare. We present our experience with 5 such complex cases and review the literature to define the types of problem and determine appropriate management. MATERIALS AND METHODS We report on 5 girls with posttraumatic urethral injuries and pelvic fracture resulting in stricture as well as management based on the site and length of urethral stricture. Associated injuries and results are discussed. RESULTS Of the 5 girls who presented with stricture 4 had undergone suprapubic cystostomy as initial treatment, whereas in 1 primary repair had failed. Urethral reconstruction using a bladder flap tube and distal urethrotomy into the vagina were performed in 3 and 1 cases, respectively. These 4 girls were continent although 1 required clean intermittent catheterization for a short period. The 3 patients with complete urethral loss had a more severe degree of pelvic fracture, including 1 treated with core through internal urethrotomy. CONCLUSIONS Posttraumatic urethral injury accompanying pelvic fracture in young girls results in challenging management situations. More severely displaced pelvic fracture is associated with greater urethral loss and requires more complex repair. Cases of partial urethral injury or urethral transection without much displacement are better managed by primary repair of the transected urethra, which decreases morbidity. Primary repair may not be feasible in patients with extensive injury, who should be treated with secondary appropriate reconstruction after preliminary suprapubic cystostomy. Complete urethral loss may be managed by bladder flap tube neourethra creations with effective continence and excellent outcomes. Short segment distal urethral strictures may be treated with meatotomy or core through internal urethrotomy.

Dorsal buccal mucosal graft urethroplasty by a ventral sagittal urethrotomy and minimal-access perineal approach for anterior urethral stricture.

In the mini‐review section of this issue, the use of buccal mucosal grafts in urethroplasty is described and the authors raise the point that it may now be the ‘reference’ standard. In this section, authors from New Dehli describe these technique of anterior urethral reconstruction for long strictures using buccal mucosal grafts. Their rather novel approach is of interest, and they report good results with up to 16 months of follow‐up.

Core-Through Optical Internal Urethrotomy in Management of Impassable Traumatic Posterior Urethral Strictures

During a 2 1/2-year period 10 patients with a traumatically obliterated posterior urethra underwent core-through optical internal urethrotomy 3 to 6 months after pelvic fracture. After 6 to 24 months of followup the peak urine flow rate was more than 15 ml. per second in 6 patients and 8 to 15 ml. per second in 2. Six patients were continent and 2 had transient stress urinary incontinence. Of the 10 patients 2 were failures because of peak urinary flow rates less than 8 ml. per second and/or urinary incontinence. Subsequently, 1 patient underwent successful scrotal flap urethroplasty. Core-through optical internal urethrotomy is an attractive alternative to urethroplasty when the impassable stricture is short.

Transperitoneal and retroperitoneal laparoscopic nephrectomy for giant hydronephrosis.

PURPOSE We evaluate laparoscopic nephrectomy for giant hydronephrosis with an emphasis on the operative technique of retroperitoneoscopic surgery. MATERIALS AND METHODS During the last 2 years 13 men and 5 women underwent laparoscopic nephrectomy for giant hydronephrosis via a transperitoneal (6) or retroperitoneal (12) approach. The etiology was congenital ureteropelvic junction obstruction in 17 patients and hydronephrosis caused by stone disease in 1. Three patients had a contralateral obstructed kidney. Renal parameters were normal in all patients. RESULTS All procedures were successfully completed without the need for conversion to open surgery. Mean operating time was 113.8 minutes (range 70 to 165) and average blood loss was 260 ml. (range 40 to 600). No patient required a blood transfusion. Postoperative recovery was uneventful with an average postoperative hospital stay of only 3.2 days (range 2 to 5). CONCLUSIONS Laparoscopic nephrectomy is a good alternative to open surgery for giant hydronephrosis and significantly reduced the morbidity of surgery. A retroperitoneal approach is feasible, despite the large amount of retroperitoneal space occupied by these hugely dilated kidneys. Modifications of our technique have been invaluable to the successful outcome in this series.