N Possemato

The role of imaging in the evaluation of joint involvement in 102 consecutive patients with systemic lupus erythematosus

OBJECTIVE To assess the prevalence of joint involvement in consecutive patients with systemic lupus erythematosus (SLE) by means of clinical assessment, joint US and MRI and to evaluate the sensitivity and specificity of physician evaluation of joint involvement. METHODS At enrollment, patients underwent a complete physical examination including a 44-joint count, and hand deformities were scored. On the day of enrollment, each patient underwent a non-dominant hand-wrist ultrasound (US) examination and a non-dominant hand-wrist MRI study without contrast injection. RESULTS One hundred and two patients (F 95, M 7) were enrolled. By physician examination hand or wrist involvement was diagnosed in 23.5%. At least one pathological finding was revealed by US examination at wrist and/or hand joints in 55%. We found a low sensitivity (46.5%) with high specificity (93.2%) of the physician assessment for the evaluation of joint involvement. The MRI imaging showed at least one erosion in 47.3% patients at the hand and in 98.9% at the wrist; in healthy subjects erosions were found in 19.6% and 97.8% at the hand and wrist, respectively. CONCLUSIONS In conclusion, (i) physicians tend to underestimate the severity of joint involvement in SLE; (ii) US assessment shows a high prevalence of joint and tendon involvement; and (iii) the MRI evaluation shows a high prevalence of damage, suggesting that joint involvement in SLE could be more severe than expected.

A case of adult periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome associated with endocapillary proliferative glomerulonephritis

PFAPA is an acronym for periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis. This syndrome has been usually described in pediatric patients and it generally resolves spontaneously. The endocapillary proliferative glomerulonephritis (EPG) is a glomerular injury characterized by hypercellularity in glomerular lumen and is caused by post-infectious or autoimmune diseases. In this paper, we describe the case of a 35-year-old man affected by PFAPA and EPG. To our knowledge this association has never been reported in the literature before.

SAT0179 Mri Pattern of Arthritis in Sle: A Comparative Study with Rheumatoid Arthritis and Healthy Subjects

Background Arthritis in systemic lupus erythematosus (SLE) is traditionally considered mild and non erosive, however chronic pain, hand disability and deformities are frequently reported by patients with longstanding disease. Magnetic resonance imaging (MRI) has demonstrated to be more sensitive for identifying bone damage than conventional radiography and it is widely used as an outcome measure of joint damage in rheumatoid arthritis (RA) clinical trials. Objectives In this study we aimed at describing the magnetic resonance imaging (MRI) pattern of distribution of bone marrow oedema (BME) and joint erosion in hands and wrists of patients with Systemic Lupus Erythematosus (SLE) with arthritis in comparison with Rheumatoid arthritis (RA) and healthy subjects (H). Methods SLE patients with arthritis (n=50), patients with RA (n=22) and H (n=48) were enrolled. Every patient underwent a non dominant hand (2nd–5th metacarpophalangeal joints) and wrist MRI without contrast injection with a low- field extremity dedicated 0.2 Tesla instrument. Results BME was observed in 2 SLE patients at hand (4%) and in 15 at wrist (13%) versus 3 (30%) and 14 (63%) RA patients. No BME was found in H. Erosions were observed at the hand in 24 SLE patients (48%), 15 RA patients (68%) and 9 H (18%); at the wrist, in 41 (82%) SLE, all RA and 47 (97%) H. The cumulative erosive burden in SLE was significantly higher than in H (p=0.002) but similar to RA patients. In SLE, erosions were more frequent at the distal side of the metacarpophalangeal joints; the II and III phalangeal basis were the most affected joints with a 20% prevalence of erosions for both. Similarly to SLE, in RA erosion were observed predominantly at the distal side of the metacarpophalangeal joints, however in comparison to SLE, RA patients showed a significantly more frequent involvement of II-IV metacarpal heads, III and V phalangeal basis. Some erosions were also detected in H in the hand and the II, III and V phalangeal basis were the most involved bones (9%, 7% and 7%, respectively).At wrist, lunate, triquetrum and capitate were the most frequently affected bones in all the three groups.By excluding the bones frequently affected also in H, in SLE the most affected sites were hamate (40%), scaphoid (38%), radius (32%) and the I metacarpal base (30%).In RA patients, scaphoid, hamate and radius were the most affected bones (in 59%, 54% and 54% respectively); trapezius and the II-III metacarpal basis were also frequently involved. With respect to SLE patients, in RA significantly more erosions were detected at the trapezius and at the II-IV metacarpal basis. Conclusions Joint involvement in SLE can be severe with a significant tendency to develop BME and erosions, similarly to RA; this condition is not rare as previously expected. Disclosure of Interest None declared DOI 10.1136/annrheumdis-2014-eular.5100