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Absorption spectroscopy of EBT model GAFCHROMIC™ film

The introduction of radiochromic films has solved some of the problems associated with conventional 2D radiation detectors. Their high spatial resolution, low energy dependence, and near-tissue equivalence make them ideal for measurement of dose distributions in radiation fields with high dose gradients. Precise knowledge of the absorption spectra of these detectors can help to develop more suitable optical densitometers and potentially extend the use of these films to other areas such as the measurement of the radiation beam spectral information. The goal of this study is to present results of absorption spectra measurements for the new GAFCHROMIC film, EBT type, exposed to 6 MV photon beam in the dose range from 0 to 6 Gy. Spectroscopic analysis reveals that in addition to the two main absorption peaks, centered at around 583 and 635 nm, the absorption spectrum in the spectral range from 350 to 800 nm contains six more absorption bands. Comparison of the absorption spectra reveals that previous HD-810, MD-55, as well as HS GAFCHROMIC film models, have nearly the same sensitive layer base material, whereas the new EBT model, GAFCHROMIC film has a different composition of its sensitive layer. We have found that the two most prominent absorption bands in EBT model radiochromic film do not change their central wavelength position with change in a dose deposited to the film samples.

Sensitivity of linear CCD array based film scanners used for film dosimetry.

Film dosimetry is commonly performed by using linear CCD array transmission optical densitometers. However, these devices suffer from a variation in response along the detector array. If not properly corrected for, this nonuniformity may lead to significant overestimations of the measured dose as one approaches regions close to the edges of the scanning region. In this note, we present measurements of the spatial response of an AGFA Arcus II document scanner used for radiochromic film dosimetry. Results and methods presented in this work can be generalized to other CCD based transmission scanners used for film dosimetry employing either radiochromic or radiographic films.

SU-E-T-462: Impact of the Radiochromic Film Energy Response On Dose Measurements of Low Energy Electronic Brachytherapy Sources

Purpose: We investigated the effect of the EBT3 GafChromicTM film model absorbed dose energy response when used for percent depth dose (PDD) measurements in low-energy photon beams. Methods: We measured PDDs in water from a Xoft 50 kVp source using EBT3 film, and compared them to PDD measurements acquired with a PTW-TN34013 parallel-plate ionization chamber. For the x-ray source, we simulated spectra using the EGSnrc (BEAMnrc) Monte Carlo code, and calculated Half Value Layer (HVL) at different distances from the source in water. Pieces of EBT3 film were irradiated in air and calibration curves were created in terms of air-kerma in air ((Kair)air) for different beam qualities. Pieces of EBT3 film were positioned at distances of 2–6 cm from the Xoft source in a water phantom using a custom-made holder, and irradiated at the same time. As scatter is incorporated in the measured film signal in water, measured (Kair)wat was subsequently converted into absorbed dose to water by the ratio of mass energy absorption coefficients following the AAPM TG-61 dosimetry protocol. Results: Our results show that film calibration curves obtained at beam qualities near the effective energy of the Xoft 50 kVp source in water lead to variation in absorbed dose energy dependence of the response of around 3%. However, if the calibration curve was established at MV beam quality, the error in absorbed dose could be as large as 15%. We observed agreement within 1% between PDD measurements using EBT3 film model (using a calibration curve obtained at 80 kVp, HVL=2.18 mm Al, Eeff=29.5 keV) and the parallel-plate ionization chamber. Conclusion: Accurate dose measurements using radiochromic films at low photon energies require that the radiochromic film dosimetry system be calibrated at corresponding low energies, as large absorbed dose errors are expected for calibrations performed at MV beam qualities.

WE-FG-202-04: Decomposition of FDG-PET Based Differential Uptake Volume Histograms in Rectal Cancer Patients

PURPOSEnThe goal of this study is to test the possible use of the analytical decomposition of differential uptake volume histograms (dUVHs) obtained from FDG-PET/CT data to isolate sub-volumes within a tumor known as biological target volumes (BTVs).nnnMETHODSnA retrospective study was conducted on a cohort of 20 histo-pathologically confirmed rectal adenocarcinoma patients having PET/CT scans for staging. All patients (T3N0) underwent pre-operative endorectal brachytherapy. After surgery, patients were restaged: 10 patients were T0N0 and 10 were restaged as remaining T3N0. The extent of the disease was sampled in order to create dUVHs; subsequently decomposed into the fewest number of analytical Gaussian functions.nnnRESULTSnWith the assumption that each function fit corresponded to a single sub-volume within the tumor, six sub-volumes were found to consistently emerge. The first two sub-volumes were influenced by contouring and were not considered in the analysis. For the T3N0 population, abundances for volumes V3-V6 were 63.6%±11.3%, 25.7%±8.4%, 6.1%±4.9%, and 4.7%±2.6%. For the T0N0 population, they were 50.2%±6.8%, 33.4%±4.3%, 11.8%±7.6%, and 4.7%±2.4%. The two populations were compared using two tailed T-tests: volumes 3 and 4 were statistically different with p values of 0.021 and 0.056 respectively. V6 was located at 8.63 ± 2.2 for T0N0 and 6.14 ± 0.78 for T3N0 group (p=0.016).nnnCONCLUSIONnWe described a method for dUVH decomposition using FDG-PET images of rectal adenocarcinoma patients that subsequently went for pre-operative brachytherapy. In addition to extracting different sub-volumes corresponding to different FDG uptake levels, we observed different abundances of two sub-volumes as well as positions of the maximum uptake between the two patient groups. In addition to opening the door to further investigation into underlying physiological phenotypes of segmented subvolumes and their use for biological radiotherapy treatment planning, this method may also provide parameters that could correlate to clinical outcomes in radiotherapy patients.

Poster — Thur Eve — 20: CTDI Measurements using a Radiochromic Film-based clinical protocol

The purpose of the study was evaluating accuracy and reproducibility of a radiochromic film-based protocol to measure computer tomography dose index (CTDI) as a part of annual QA on CT scanners and kV-CBCT systems attached to linear accelerators. Energy dependence of Gafchromic XR-QA2 ® film model was tested over imaging beam qualities (50 – 140 kVp). Film pieces were irradiated in air to known values of air-kerma (up to 10 cGy). Calibration curves for each beam quality were created (Film reflectance change Vs. Air-kerma in air). Film responses for same air-kerma values were compared. Film strips were placed into holes of a CTDI phantom and irradiated for several clinical scanning protocols. Film reflectance change was converted into dose to water and used to calculate CTDIvol values. Measured and tabulated CTDIvol values were compared. Average variations of ±5.2% in the mean film reflectance change were observed in the energy range of 80 to 140 keV, and 11.1% between 50 and 140 keV. Measured CTDI values were in average 10% lower than tabulated CTDI values for CT-simulators, and 44% higher for CBCT systems. Results presented a mean variation for the same machine and protocol of 2.6%. Variation of film response is within ±5% resulting in ±15% systematic error in dose estimation if a single calibration curve is used. Relatively large discrepancy between measured and tabulated CTDI values strongly support the trend towards replacing CTDI value with equilibrium dose measurement in the center of cylindrical phantom, as suggested by TG- 111.

SU-F-18C-10: Clinical Implementation of Radiochromic Film Based CTDI Measurements

PURPOSEnTo evaluate accuracy and reproducibility of a radiochromic film-based protocol to measure computer tomography dose index (CTDI) as a part of annual QA on CT scanners and kV CBCT systems attached to linear accelerators.nnnMETHODSnEnergy dependence of Gafchromic XR-QA2(R) film model was tested over imaging beam qualities (50 - 140 kVp). Film pieces were irradiated in air to known values of air kerma in air (up to 10 cGy). Change in film reflectance was determined with an in-house written code using images produced by a flatbed document scanner. Calibration curves for each beam quality were created, and film responses for same air-kerma values were compared.Sets of film strips were placed into holes of a CTDI phantom and irradiated for several clinical scanning protocols on CT-simulators and CBCT systems. Film reflectance change was converted into dose to water and used to calculate CTDIvol values. Measured CTDIvol values were compared to tabulated CTDIvol values.nnnRESULTSnAverage variations of ±5.2% in the mean film reflectance change were observed in the energy range of 80 to 140 keV, and 11.1% between 50 and 140 keV. The averaged measured CTDI values presented a mean variation for the same machine and protocol of 2.6%. However, measured CTDI values were in average 10% lower than tabulated CTDI values for CT-simulators, and 44% higher for CBCT systems.nnnCONCLUSIONnWe found that in relatively broad range of beam qualities used in diagnostic radiology variation of film response is within ±5% resulting in ±15% systematic error in dose estimates if a single calibration curve is used. Relatively large discrepancy between measured and tabulated CTDI values for different protocols and imaging systems used within radiotherapy department strongly support the trend towards replacing CTDI value with equilibrium dose measurement in the center of cylindrical phantom as suggested by TG-111. This work was supported by the Natural Sciences and Engineering Research Council of Canada, Contract No. 386009; Partial support by CREATE, Medical Physics Research Training Network grant of the Natural Science and Engineering Research Council, Contract No. 432290.

TH-E-BRB-02: Linearization of Dose Response Curve for the Radiochromic Film Dosimetry System

Purpose: In order to measure relative dose distribution with radiochromic film, one need to first measure an absolute dose (following previously established reference dosimetry protocol) and then convert measured absolute dose into relative dose. We present here result of our efforts to establish a functional form that converts the inherently non‐linear dose response curve of the radiochromic film dosimetry system into liner one. Methods: In order to test the invariance of the proposed functional form with respect to the film or scanner model used, we have tested it on film pieces from three different GAFCHROMICTM film models (EBT, EBT‐2, and EBT‐3) irradiated to various doses and scanned on a single scanner. for one of the film models we have also tested it by scanning with three different flatbed scanner models (Epson V700, 1680, and 10000XL). To test our hypothesis that the proposed functional argument linearizes the response of the radiochromic film dosimetry system, we performed a measurement of percent depth dose (PDD) curves in Cobalt‐60 beam. Results: Obtained R2 values indicate that the choice of the functional form of the new argument (ζ) appropriately linearizes the dose response of the radiochromic film dosimetry system we used. The linear behavior was insensitive to both film model and flatbed scanner model used. Measured PDD values using the green channel response of the GAFCHROMICTM EBT‐3 film model are well within ±2% window of the local relative dose value when compared to the tabulated Cobalt‐60 data. Conclusions: We demonstrate the use of a unique functional argument to linearize the inherently non‐linear response of a radiochromic film based reference dosimetry system. In this way, relative dosimetry can be conveniently performed using radiochromic film dosimetry system without the need of establishing an absolute calibration curve. One author is from GAFCHROMICTM films manufacturer

SU‐E‐T‐113: Measurement of the Cutout Output Factor on Ortho‐Voltage Unit Using EBT‐2 Model GafchromicTM Film

Purpose: In this study, we evaluate feasibility of using EBT‐2 model GafchromicTM film to measure patient specific cutout output factors on an ortho‐voltage treatment machine. Methods: A Gulmay Orthovoltage D3225 unit was used to produce clinical beams in kV range from 50 kVp to 220 kVp. Previously established air kerma based radiochromic film dosimetry protocol for low energy x‐ray beams was used. A closed‐end applicator with 10 × 10 cm2 field size and SSD 50 cm was employed. Cutouts were made from a lead sheet of 1.8 mm in thickness. A 6‐cm thick slab of Solid WaterTM was used as a backscatter material for output factor measurement. In‐house made MatLab routines were used to analyze scanned images of exposed and unexposed films and a PTW 23342 parallel‐plate ion chamber (PP IC) was used to measure the cutout output factors for comparison. Results: Air‐Kerma based calibration curve was created in the 1–300 cGy range. Film dosimetic accuracy was verified for known doses to water of 1.00 and 2.00 Gy, respectively, with maximum observed difference of 0.4%. Two‐dimensional dose maps and dose profiles were obtained for various cutout sizes ranging from 0.8 cm diameter circle to 10 × 10 cm2 square. Comparisons of output factors between film and pp ion chamber measurements show that there are no differences for large cutouts but the chamber measurements are up to 11 % higher for small cutout size. Conclusions: We demonstrated that the air‐Kerma based radiochromic film dosimetry protocol using EBT‐2 model GafChromicTM film for low energy x‐ray beam is adequate for patient specific cutout output measurements on orthovoltage units, especially for small size cutout measurements, where IC measurements give higher output factor than films due to ICs over responses to electron contaminations from lead sheets.

SU‐E‐T‐378: Radiochromic Film Based Reference Dosimetry System for 192Ir Brachytherapy Sources

Purpose: Comparison between radiochromic film reference dosimetry system calibration curves established in water and Solid Water(TM) for high dose rate (HDR) 192‐Iridium brachytherapysource is described and assessed. Accordingly, a new reference dosimetry system protocol for HDR 192‐Iridium using the latest EBT‐2 model GAFCHROMIC(TM) film is suggested. Methods: Calibration curves were established in water and Solid Water(TM) using pieces of EBT‐2 GAFCHROMIC(TM) film irradiated with HDR 192‐Iridium brachytherapysource for a dose range from 0 to 50 Gy. A parallel‐opposed beam setup was specially designed to allow the positioning of the HDR source into two channels (catheters) with the film piece positioned mid‐way between them. This setup increases the dose homogeneity region over the film piece and reduces the positional uncertainty with respect to the radiation source. Responses of dosimetry systems were compared for irradiations in water and Solid Water(TM) by scaling the dose between media through Monte Carlo‐calculated conversion factor simulated for the two setups.Results: Monte Carlo calculated conversion factor, which converts dose delivered to the sensitive layer of the film in water to a dose delivered to the sensitive layer of the film in Solid Water(TM), was found to be 0.9941±0.0007. The EBT‐2 GAFCHROMIC(TM) film based reference dosimetry system described in this work can provide an overall one‐sigma uncertainty in measured dose of 2% for doses above 1 Gy Conclusions: Experimental confirmation of the Monte Carlo‐calculated factor that shows dose difference between measurements in water and Solid Water(TM) was provided. The remaining 0.6% difference between measurements in both media shows that Solid Water(TM) is a viable alternative to water as a reference medium in establishing the calibration curve at 192‐Iridium energy. Response curves utilizing green color channel only has shown superior precision if used alone in dosimetry for dose range that extends up to 50 Gy. This work was supported by the Natural Sciences and Engineering Research Council of Canada contract No. 386009. Saad Aldelaijan would like to acknowledge Saudi Food & Drug Authority for financial support during his graduate studies.

Absorption spectroscopy of EBT model film

The introduction of radiochromic films has solved some of the problems associated with conventional 2D radiation detectors. Their high spatial resolution, low energy dependence, and near-tissue equivalence make them ideal for measurement of dose distributions in radiation fields with high dose gradients. Precise knowledge of the absorption spectra of these detectors can help to develop more suitable optical densitometers and potentially extend the use of these films to other areas such as the measurement of the radiation beam spectral information. The goal of this study is to present results of absorption spectra measurements for the new GAFCHROMIC film, EBT type, exposed to 6 MV photon beam in the dose range from 0 to 6 Gy. Spectroscopic analysis reveals that in addition to the two main absorption peaks, centered at around 583 and 635 nm, the absorption spectrum in the spectral range from 350 to 800 nm contains six more absorption bands. Comparison of the absorption spectra reveals that previous HD-810, MD-55, as well as HS GAFCHROMIC film models, have nearly the same sensitive layer base material, whereas the new EBT model, GAFCHROMIC film has a different composition of its sensitive layer. We have found that the two most prominent absorption bands in EBT model radiochromic film do not change their central wavelength position with change in a dose deposited to the film samples.