N. Vasudeva Reddy

Microwave Assisted Knoevenagel Condensation Using Sodium Fluoride and Lithium Chloride as Catalysts Under Solvent-Free Conditions

Abstract Microwave assisted Knoevenagel condensation of aromatic aldehydes 1 with active methylene compounds 2 under solvent free conditions to prepare arylidene compounds 3 in excellent yields using cheap and readily available NaF and LiCI as catalysts has been described.

LiCl Catalyzed Claisen–Schmidt Condensation in Solvent-Free Conditions Using Microwaves

Abstract Microwave assisted Claisen–Schmidt condensation of 2-(4-acetylphenyl-amino)-3-(4-methoxyphenyl)-1,8-naphthyridine 3 with various aromatic aldehydes under solvent-free conditions to prepare α,β-unsaturated ketones 4 using LiCl as catalyst has been described. The products are obtained in good yields and excellent purities.

AN EXCEEDINGLY MILD AND EFFICIENT SYNTHESIS OF 1,2,4-TRIAZOLO[4,3-a][1,8]NAPHTHYRIDINES USING IODOBENZENE DIACETATE IN THE SOLID STATE

ABSTRACT An efficient and mild method for the synthesis of 1,2,4-triazolo[4,3-a][1,8]naphthyridines using iodobenzene diacetate (IBD) in the solid state at room temperature has been described. The reaction proceeds efficiently at room temperature in good yields and in a solid of high purity.

Synthesis and antibacterial activity of (1-aryl-1, 2, 3-triazol-4-yl) methyl esters of morpholine-3-carboxylic acid

A series of new 1,2,3-triazolyl methyl ester of morpholine-3-carboxylic acid analogues were designed and synthesized employing click chemistry by using Huisgen 1,3 dipolar cyclo addition reaction between propargyl ester of morpholine-3-carboxylic acid and aryl azides. The starting materials propargyl ester and aryl azides were synthesized by well established methods. The newly synthesized compounds were characterized by spectral studies. The compounds were screened for antibacterial activity. Majority of the compounds exhibited promising activity and one of them (6i) displayed more activity than standard drug against S. paratyphi-B. A molecular docking study showed hydrogen bonds and pi-interactions with the compound. Our data indicate that these derivatives may present promising anti-bacterial agents.Graphical Abstract

Zeolite-HY Catalyzed Synthesis of 1,8-Naphthyridinyl-3(2H)-pyridazinones in Dry Media Under Microwave Irradiation

Abstract An efficient and rapid method for the synthesis of 1,8-naphthyridinyl-3(2H)-pyridazinones in dry media under microwave irradiation is described using zeolite-HY supported on silica gel. The products are obtained in excellent yields and in a state of high purity.

Mild and Efficient Synthesis of Phthalazine-1,4-diones Using PTSA in the Solid State

Abstract A rapid and efficient method for the synthesis of 1,8-naphthyridine-3-carbonyl phthalazine-1,4-diones by the condensation of 1,8-naphthyridine-3-carboxylic acid hydrazides with phthalic anhydride using p-toluenesulphonic acid (PTSA) as a catalyst under solid state conditions has been described. The reaction proceeds efficiently at room temperature in excellent yields and in a state of high purity.

An efficient and novel method for the synthesis of β-aroylpropionic acids under solvent-free conditions

Abstract A simple and rapid reaction of succinic anhydride with aromatic hydrocarbons is described. The reaction is conducted under Friedel–Crafts conditions in the absence of solvent at room temperature using aluminium chloride as catalyst.