N. Zivkovic

P.3.016 Oxcarbazepine, topiramate and lamotrigine in the treatment of alcohol craving

The significance of differences between average measurements in the two groups was assessed using Student’s t-test. Significance was set at p< 0.05. Statistical analysis was performed using the STATA Data Analyses Tool: Regression statistics; Two-sample t test with equal variances, Bartlett’s test for equal variances, Bonferroni test. Results: The levels of vitamin B12 and folic acid were found to be normal for all patients. The mean level of Hcy was 11.94±5.6mmol/L for patients with schizophrenia spectrum disorders and 11.26±3.3mmol/L for patients with affective disorders versus 7.47±2.9mmol/L for controls. The highest level of Hcy in the schizophrenia patients was seen in those with an episodic-recurrent disease course, in particular for acute onset and pronounced affect. For the group with affective disorders the highest level was seen in patients with depressive symptoms with anxiety and in patients with mixed affective disorders (r = −0.58; p< 0.01). No associations were found between patient groups, the level of Hcy and MTHFR gene polymorphism. Conclusions: These data suggest a potential link between Hcy level and pronounced affect in schizophrenia and affective disorders, as well as disease severity and course. However, no association was found between Hcy level, schizophrenia and affective disorders and the MTHFR 677C→T polymorphism.