Naci Gürses

Effects of estradiol and progesterone on the synthesis of collagen in corrosive esophageal burns in rats

The effects of sex hormones on the synthesis of collagen were investigated in rats with alkali-induced corrosive esophageal burns. In 75 rats, a standard esophageal burn was produced as described by Gehanno. The animals were then grouped as follows: controls (group A), animals with pure esophageal burns (group B), and animals with esophageal burns treated with estradiol and progesterone (group C). All animals were killed on the 28th day of the experiment. Hydroxyproline levels were determined, and histopathologic evaluation was performed for each group. The hydroxyproline levels were significantly lower in the rats treated with estradiol and progesterone. Histopathologically, collagen deposition in the submucosa and tunica muscularis was lower in the estradiol/progesterone group than in the group with pure esophageal burns. Based on the results, the authors believe that estradiol and progesterone inhibited new collagen synthesis, and therefore, alkali-induced esophageal stricture formation.

A case of anterior sacral meningocele totally excised using the posterior sagittal approach

Anterior sacral meningocele is a rare congenital anomaly. The authors present a case of anterior sacral meningocele successfully excised using the posterior sagittal approach. The diagnosis and treatment of this unusual anomaly are discussed.

Superior lumbar hernia associated with the lumbocostovertebral syndrome

A child with a superior lumbar hernia associated with the lumbocostovertebral syndrome is described. Congenital lumbar hernias are uncommon, with only 34 reported cases. Because of the difficulty of finding adequate tissue to repair these defects, we performed a prosthetic repair with a polytetrafluoroethylene (Gore-Tex) patch.

Unilateral inguinal ectopic scrotum and imperforate anus: A case report

A case of an ectopic scrotum located in the right inguinal area is described. The left hemiscrotum was in normal location, and each hemiscrotum contained testis. The boy also had an infralevator-type anorectal malformation. Initially, anoplasty was performed, and scrotal reconstruction was carried out 1 month later. The authors also reviewed the embryological explanation of ectopic scrotum in the literature.

Pentalogy of Cantrell.

Omphalocele is often, associated with various abnormalities. In two patients admitted with omphalocele, we additionally found defects both in the pars stenalis of diaphragm and in the diaphragmatic surface of the pericardium, sternal defect and tetralogy of Fallot. These entities form the components of a syndrome, named pentalogy of Cantrell. It is extremely in the spectrum of midline closure defects that display wide variations and its incidence is very low. Existing cardiac defect is the most important factor influencing morbidity and mortality. Herein we report two cases of pentalogy of Cantrell with the review of the syndrome in the light of literature.

Intraoperative diagnostic pneumoperitoneum in pediatric patients with unilateral inguinal hernias: Goldstein test

Over a 4-year period, 321 infants and children with unilateral inguinal hernias underwent intraoperative diagnostic pneumoperitoneum to evaluate the contralateral groin for a patent processus vaginalis. Seventy-four patients had positive results and underwent contralateral hernia repair at the same time. Of the 247 patients with negative tests, 3 presented later with a hernia (false-negative rate 1,21%). There were no complications related to the procedure itself. Intraoperative diagnostic pneumoperitoneum (Goldstein test) is a useful, safe, simple, and highly accurate means to evaluate the contralateral groin.

Indomethacin for prevention of stricture formation due to alkali-induced corrosive esophageal burns in the rat

The aim of this study was to investigate the therapeutic effect of indomethacin on corrosive esophageal strictures. Esophageal burns were produced in 40 of 50 Sprague-Dawley rats by 10.7% NaOH and were then grouped as pure esophageal burns, esophageal burns treated with indomethacin, and controls. All of the animals were killed on the 28th day of the experiment and hydroxyproline levels in esophageal tissue were determined for each rat. Hydroxyproline levels were significantly lower in the indomethacin-treated group than in the other two groups. Based on our results, we suggest that indomethacin inhibited collagen synthesis and thus alkali-induced esophageal stricture formation.

Pelvic ganglioneuroblastoma totally excised using posterior sagittal and abdominal approach

Neuroblastoma usually presents as an upper abdominal mass arising from the adrenal gland. Recent experience with neuroblastoma of the spermatic cord, bladder, and pelvis demonstrates the propensity of this tumor to arise in unusual areas. A 1-year-old boy was admitted with pollakiuria, acute urinary retention, and chronic constipation. Computed tomographic and ultrasonographic examinations revealed a 5×5.5×4-cm pelvic mass, which was totally excised using a posterior sagittal and abdominal approach. The pathologic diagnosis was ganglioneuroblastoma and 1-year follow-up was uneventful.

A case of ectopic anus localized on the right gluteus

A case of a gluteus-localized ectopic anus on the right side is described. A 5-month-old boy had a severe sacral anomaly with atrophy of the right lower extremity and a pes equinus deformity. Transcutaneous muscle stimulation showed a well-developed muscle complex, and parasagittal muscle fibers have been localized obliquely. Although he has severe sacral anomalies, the posterior sagittal anorectoplasty procedure could be performed. This unique case provides a good demonstration of not only the ectopically localized anus but also the ectopically localized muscle complex.

A very rare type of multiple intestinal atresias: “A string of pearls”

Intestinal atresia is themost frequently encountered cause of ileus in the neonate. Of all atresias combination of small and large bowel atresias is extremely rare. In 1973, Guttman presented a case with multiple, widespread atresias of small and large bowel, intraluminal calcifications and a hereditary nature. This paper describes the detailed pathological findings of a similar case of multiple intestinal atresias and discusses for the pathogenesis of this rare condition.