Nadia Kerkeni

Spectrum of autoimmune blistering dermatoses in Tunisia: an 11-year study and a review of the literature

Background  Autoimmune bullous dermatoses (ABD) are a rare but significant group of cutaneous disorders posing great diagnostic and therapeutic challenges to the treating dermatologist. Few surveys have been carried out to describe the whole spectrum of ABD in a region.

Endogenous ochronosis: case report and a systematic review of the literature

Background  Endogenous ochronosis (EO) is a rare autosomal recessive disorder due to accumulation of oxidized and polymerized forms of homogentisic acid (HGA) in connective tissues, giving them a deep dark blue pigmentation.

IgG/IgA pemphigus with IgG and IgA antidesmoglein 3 antibodies and IgA antidesmoglein 1 antibodies detected by enzyme-linked immunosorbent assay: a case report and review of the literature

IgA pemphigus represents a group of autoimmune blistering skin diseases characterized by intraepidermal neutrophilic pustules, intercellular IgA antibodies, or circulating IgA antibodies to keratinocyte surfaces. Currently, it is seen as a distinct subset of pemphigus with particular clinical and immunopathologic pictures. As it is a newly defined disorder, its frequency is unknown but surely rare. Even less reported is the pemphigus with deposits of both IgG and IgA on keratinocyte cell surfaces; a new entity described in the recent literature as IgG and IgA pemphigus. In this study, we report the first Tunisian case with IgG ⁄ IgA pemphigus and try to discuss the clinical and immunopathological features of this new type of pemphigus.

Tongue hyperpigmentation during PEG-interferon-alfa/ribavirin therapy in a non-Caucasian patient with chronic hepatitis C: a case report and review of the literature

Morphol 2002; 10: 7–14. 3 Wu YH, Chen HC, Hsiao PF, et al. Hydroa vacciniforme-like Epstein-Barr virus-associated monoclonal T-lymphoproliferative disorder in a child. Int J Dermatol 2007; 46: 1081–1086. 4 Quintanilla-Martinez L, Kimura H, Jaffe ES. EBV-positive T-cell lymphoproliferative disorders of childhood. In: Swerdlow SH, Campo E, Harris NL, et al., eds. WHO Classification of Tumors of Hematopoietic and Lymphoid Tissues. Lyon: IARC Press, 2008: 278–280. 5 Oono T, Arata J, Masuda T, Ohtsuki Y. Coexistence of hydroa vacciniforme and malignant lymphoma. Arch Dermatol 1986; 122: 1306–1309. 6 Feng S, Jin P, Zeng X. Hydroa vacciniforme-like primary cutaneous CD8-positive T-cell lymphoma. Eur J Dermatol 2008; 18: 364–365. 7 Doeden K, Hernan MK, Perez E, et al. Hydroa-like lymphoma with CD56 expression. J Cutan Pathol 2008; 35: 488–494. 8 Xu Z, Lian S. Epstein-Barr virus-associated hydroa vacciniforme-like cutaneous lymphoma in seven Chinese children. Pediatr Dermatol 2010; 27: 463–469. 9 Cohen JI, Kimura H, Nakamura S, et al. Epstein-Barr virus-associated lymphoproliferative disease in nonimmunocompromised hosts: a status report and summary of an international meeting, 8–9 September 2008. Ann Oncol 2009; 20: 1472–1482. 10 Lyssel J, Wiegleb Edstrom D, Linde A, et al. Antiviral therapy in children with hydroa vacciniforme. Acta Derm Venereol 2009; 89: 393–397.

A delayed diagnosis of lepromatous leprosy: pitfalls and clues to early recognition.

Purpose  To remind special attention to atypical symptoms of Hansen’s disease, we report a case of an atypical case due to a delayed diagnosis.

Unilateral upper limb skin sarcoid reaction after homolateral mastectomy for breast cancer

in patients with familial benign chronic pemphigus (Hailey–Hailey disease). J Am Acad Dermatol 1989; 21: 506–510. 3 Remitz A, Lauerma AI, Stubb S, et al. Darier’s disease, familial benign chronic pemphigus (Hailey–Hailey disease) and contact hypersensitivity. J Am Acad Dermatol 1990; 22: 134. 4 Pónyai G, Kárpáti S, Ablonczy E, et al. Benign familial chronic pemphigus (Hailey–Hailey) provoked by contact sensitivity in two patients. Contact Derm 1999; 40: 168– 169. 5 Walker SL, Beck MH. Undiagnosed Hailey–Hailey disease causing painful erosive changes during patch testing. Br J Dermatol 2005; 153: 253–254.

Lichen nitidus génital

icropapules, légèrement bombées, de couleur de la peau ormale, brillantes, de 1 à 2 mm de diamètre et siégeant sur e fourreau de la verge, le gland et les bourses (Fig. 1). Le este du tégument était indemne. Les muqueuses et les phaères étaient sains. L’examen histologique d’une lésion du ourreau montrait une atrophie épidermique associée à un nfiltrat dense, micronodulaire, bien limité, comportant des ymphocytes, des plasmocytes, des histiocytes et des celules géantes (Fig. 2). Le diagnostic de lichen nitidus (LN) tait retenu. La biologie était normale. Un antihistaminique nti-H1 per os était prescrit après avoir rassuré le patient sur a bénignité de l’affection. Aucun traitement local n’était réconisé.

Cutaneous metastasis in an old surgical scar revealing gastric linitis.

affected in the tropics. The biopsy shows hyperplasia with poorly defined noncaseating, tuberculoid granulomata. The visualization or their isolation from culture is rarely positive, and Mantoux test is usually positive. Mantoux test negativity in any case of tuberculosis is related to low immunity, but in our case, systemic workup provided no evidence of abnormalities. Lesions tend to be chronic but remain sensitive to specific anti-TB treatment, which can act as a diagnostic tool. Conventional antitubercular treatment should be administered in the same way as for systemic tuberculosis. The differential diagnosis should include verrucous leishmaniasis, chromoblastomycosis, sporotrichosis, lobomycosis, tertiary syphilis, and mycobacterial infection other than tuberculosis. Hypertrophic lichen planus, rupioid psoriasis, and verrucous carcinoma should also be considered.

Tumeur de la paupière supérieure

n homme, âgé de 71 ans, nous a consulté pour une umeur de la paupière supérieure gauche évoluant depuis uatre mois. À l’examen, il s’agissait d’une lésion noduaire, hémisphérique, pigmentée et sessile de 8 mm de iamètre environ, d’aspect exophytique et verruqueux à entre déprimé et à base non infiltrée (Fig. 1). Une exéèse de la lésion a été pratiquée. L’aspect histologique de a lésion est illustré par les Fig. 2 et 3.