Nadia Pastori
Polytechnic University of Milan
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Featured researches published by Nadia Pastori.
Molecules | 2012
Bianca Rossi; Simona Prosperini; Nadia Pastori; Angelo Clerici; Carlo Punta
Titanium complexes have been widely used as catalysts for C-C bond-forming processes via free-radical routes. Herein we provide an overview of some of the most significant contributions in the field, that covers the last decade, emphasizing the key role played by titanium salts in the promotion of selective reactions aimed at the synthesis of multifunctional organic compounds, including nucleophilic radical additions to imines, pinacol and coupling reactions, ring opening of epoxides and living polymerization.
Organic Letters | 2008
Angelo Clerici; Alessandra Ghilardi; Nadia Pastori; Carlo Punta; Ombretta Porta
An amine, an aldehyde, and methanol can be readily assembled in one pot under very mild conditions through a free-radical multicomponent reaction by using an aqueous acidic TiCl3/t-BuOOH system to afford 1,2-amino alcohols in fair to excellent yields.
Tetrahedron Letters | 1992
Elena Vismara; Giangiacomo Torri; Nadia Pastori; Marco Marchiandi
Abstract Photolysis of 2,3:4,6-di-O-isopropylidene-2-keto-L-gulonic acid 1 and methyl-2,3-O-isopropylidene-β- d -ribofuranosiduronic acid 2 mediated by (diacetoxy)iodobenzene in the presence of protonated heteroaromatic bases provides a new stereoselective synthesis of C-nucleosides and C-nucleoside analogues, via radical pathways.
Organic Letters | 2010
Nadia Pastori; Cosimina Greco; Angelo Clerici; Carlo Punta; Ombretta Porta
A free radical multicomponent reaction mediated by an acidic TiCl(4)-Zn/H(2)O(2) system allows the assembly of an amine, a ketone, and formamide in one pot, affording instant access to quaternary alpha-amino acid derivatives.
Organic and Biomolecular Chemistry | 2011
Simona Prosperini; Nadia Pastori; Alessandra Ghilardi; Angelo Clerici; Carlo Punta
We report a new and fast domino synthesis of aminoalcohols under mild conditions. The free-radical reaction of aliphatic and aromatic amines with alcohol cosolvents is promoted by means of the TiCl(4)-Zn/t-BuOOH system. According to the proposed mechanism, the amine reacts with two molecules of alcohol in an electrophilic-nucleophilic cascade process. This procedure, if compared with the TiCl(3)/t-BuOOH-mediated protocol previously reported, appears to be more selective, of more general applicability and affords the desired products in higher yields. Besides, with the same catalytic system it was possible to promote the reaction of primary arylamines with two molecules of cyclic ether, leading to the formation of a wider range of functionalized aminoalcohols.
Molecules | 2015
Lucio Melone; Manuel Petroselli; Nadia Pastori; Carlo Punta
N-hydroxyphthalimide (NHPI) is an organocatalyst for free-radical processes able to promote the aerobic oxidation of a wide range of organic substrates. In particular, NHPI can catalyze the hydroperoxidation of polyunsaturated fatty acids (PUFA). This property could be of interest for biological applications. This work reports the synthesis of two β-cyclodextrin derivatives (CD5 and CD6) having a different degree of methylation and bearing a NHPI moiety. These compounds, having different solubility in water, have been successfully tested for the hydroperoxidation of methyl linoleate, chosen as the PUFA model molecule.
Beilstein Journal of Organic Chemistry | 2015
Bianca Rossi; Nadia Pastori; Simona Prosperini; Carlo Punta
Summary Following an optimized multicomponent procedure, an aryl amine, a ketone, and a cyclic ether or an alcohol molecule are assembled in a one-pot synthesis by nucleophilic radical addition of ketyl radicals to ketimines generated in situ. The reaction occurs under mild conditions by mediation of the TiCl4/Zn/t-BuOOH system, leading to the formation of quaternary β-amino-ethers and -alcohols. The new reaction conditions guarantee good selectivity by preventing the formation of secondary products. The secondary products are possibly derived from a competitive domino reaction, which involves further oxidation of the ketyl radicals.
Beilstein Journal of Organic Chemistry | 2017
Monica Ferro; Franca Castiglione; Nadia Pastori; Carlo Punta; Lucio Melone; Walter Panzeri; Barbara Rossi; Francesco Trotta; Andrea Mele
Two different formulations of cyclodextrin nanosponges (CDNS), obtained by polycondensation of β-cyclodextrin with ethylenediaminetetraacetic acid dianhydride (EDTAn), were treated with aqueous solutions of ibuprofen sodium salt (IbuNa) affording hydrogels that, after lyophilisation, gave two solid CDNS-drug formulations. 1H fast MAS NMR and 13C CP-MAS NMR spectra showed that IbuNa was converted in situ into its acidic and dimeric form (IbuH) after freeze-drying. 13C CP-MAS NMR spectra also indicated that the structure of the nanosponge did not undergo changes upon drug loading compared to the unloaded system. However, the 13C NMR spectra collected under variable contact time cross-polarization (VCT-CP) conditions showed that the polymeric scaffold CDNS changed significantly its dynamic regime on passing from the empty CDNS to the drug-loaded CDNS, thus showing that the drug encapsulation can be seen as the formation of a real supramolecular aggregate rather than a conglomerate of two solid components. Finally, the structural features obtained from the different solid-state NMR approaches reported matched the information from powder X-ray diffraction profiles.
Advanced Synthesis & Catalysis | 2011
Lucio Melone; Cristian Gambarotti; Simona Prosperini; Nadia Pastori; Francesco Recupero; Carlo Punta
Journal of Chemical Technology & Biotechnology | 2014
Lucio Melone; Simona Prosperini; Gabriele Ercole; Nadia Pastori; Carlo Punta