Naga Va Kommuri

ASSOCIATION BETWEEN NOVEL BIOMARKERS AND ARTERIAL ELASTICITY INDEX AMONG HEALTHY MULTI-ETHNIC U.S. POPULATION

Methods: Multi-Ethnic study of Atherosclerosis (MESA) is a population based study (n=6,814) of White (38%), Black (28%), Chinese (22%) and Hispanic (12%) subjects, aged 45-84 yrs, free from clinical cardiovascular disease. We performed post-hoc analysis of the NHLBI limited access dataset of MESA subjects (n=6,002) using multivariate regression analyses to determine the association of biomarkers with LAE and SAE derived from radial artery diastolic pulse wave contour registration in all subjects in a supine position using tonometry. Results: C reactive protein, interleukin-6, fibrinogen and factor-8 were negatively associated with both LAE and SAE. Plasma activated protein, homocysteine and microalbuminuria were negatively associated with SAE only and intracellular adhesion molecule levels were associated negatively with LAE. Conclusion: Markers of inflammation are associated with both LAE and SAE, whereas, markers of endothelial dysfunction and hemostasis are more strongly associated with SAE. The differential association of these biomarkers with LAE and SAE may further help our understanding of the putative biological pathways mediating adverse cardiovascular outcomes. Table 1: Association of Novel biomarkers with Arterial Elasticity Index Small Arterial Elasticity Index Large Arterial Elasticity Index Biomarkers Beta-coefficient [95% CI] p-value Beta-coefficient [95% CI] p-value High-sensitivity C-reactive protein (mg/L) -0.015 [-0.023 to -0.007] <0.001 -0.029 [-0.041 to -0.017] <0.001 Interleukin-6 (pg/mL) -0.030 [-0.043 to -0.016] <0.001 -0.036 [-0.057 to -0.016] <0.001 Plasmin-Antiplasmin Complex (nM) -0.041 [-0.064 to -0.017] 0.001 -0.012 [-0.022 to -0.047] 0.483 Fibrinogen (mg/dL) -0.071 [-0.115 to -0.027] 0.002 -0.086 [-0.150 to -0.020] 0.008 D-dimer (mcg/mL) -0.001 [-0.011 to 0.009] 0.864 0.009 [-0.005 to 0.023] 0.215 Factor-8 (%) -0.029 [-0.050 to -0.008] 0.005 -0.030 [-0.060 to -0.001] 0.049 Homocysteine (micromol/L) -0.037 [-0.067 to -0.006] 0.017 -0.032 [-0.012 to 0.076] 0.155 *Microalbuminuria (mg/g of creatinine) -0.039 [-0.071 to -0.007] 0.015 -0.015 [-0.061 to 0.031] 0.530 ¶Intercellular adhesion molecule-1 (ng/ml) -0.033 [-0.083 to 0.016] 0.188 -0.144 [-0.216 to -0.072] <0.001

ASSOCIATION BETWEEN ANTHROPOMETRIC MEASURES AND NOVEL BIOMARKERS AMONG NON-DIABETIC HEALTHY MULTIETHNIC U.S. ADULTS

Methods: Multi-Ethnic study of Atherosclerosis (MESA) is a population based study (n=6,814) of White (38%), Black (28%), Chinese (22%) and Hispanic (12%) subjects, aged 45-84 yrs, free from clinical cardiovascular disease. We performed a post-hoc analysis of the NHLBI limited access dataset of MESA subjects (N=5534) to assess the relationship between a host of novel biomarkers with measures of anthropometry using multivariate adjusted linear regression analyses.