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Featured researches published by Naima Ouzeddoun.


Saudi Journal of Kidney Diseases and Transplantation | 2014

Viral hepatitis C and B among dialysis patients at the Rabat University Hospital: Prevalence and risk factors

Zineb Lioussfi; Zineb Errami; Aicha Radoui; Hakima Rhou; Fatima Ezzaitouni; Naima Ouzeddoun; Rabea Bayahia; L. Benamar

The aim of this study is to investigate the prevalence of hepatitis C virus (HCV) and hepatitis B virus (HBV) in maintenance hemodialysis (HD) and continuous ambulatory peritoneal dialysis patients at the Rabat University Hospital and to identify the major risk factors for transmission. A retrospective study was performed in 67 chronic HD and 36 peritoneal dialysis patients. For the screening of viral infections, we tested for anti-HCV antibodies and HBs antigen (Hbs Ag). We compared infected and non-infected patients in order to determine the risk factors for contamination. In the HD unit, the prevalence of anti-HCV was 60% and the prevalence of HBs Ag was 6%. Duration of dialysis (P = 0.001) was the only risk factor in our HD patients. In peritoneal dialysis (PD), the prevalence of anti-HCV was 8%. Hbs Ag was detected in 2.6% of our PD patients. Viral hepatitis C is the main viral infection in our HD unit. The duration of dialysis is the main risk factor for infection in our study. The transmission is essentially nosocomial, requiring a strict adherence to infection control procedures.


International Journal of Nephrology and Renovascular Disease | 2013

Features and outcomes of lupus nephritis in Morocco: analysis of 114 patients

I. Haddiya; Hakim Hamzaoui; Nabil Tachfouti; Zitouna Al Hamany; Aicha Radoui; Najoua Zbiti; Yamama Amar; Hakima Rhou; L. Benamar; Naima Ouzeddoun; Rabea Bayahia

Background There is wide variation in clinical presentation and outcome of lupus nephritis (LN) among different ethnic groups. Few data for LN exist on North Africans, especially those from Morocco. The aim of our study was to review retrospectively the features and outcome of LN in Moroccan patients. Patients and methods We performed a single-center retrospective study. A total of 114 patients with LN were included. All patients met American Rheumatism Association criteria. LN was classified according to the International Society of Nephrology/Renal Pathology Society classification. We adopted previously defined outcome criteria for LN. Results There were 101 females and 13 males, with a mean age of 29.9 years. At first presentation, we noted hypertension in 33%, hematuria in 76%, nephrotic syndrome in 53%, and renal failure in 60% of cases. Renal biopsy revealed predominant proliferative classes in more than 80% of patients. Patients received different regimens mainly based on intravenous cyclophosphamide. After a mean follow-up of 22 months, remission occurred in 45.5%, relapses in 82%, end-stage renal failure in 21%, and death in 16% of cases. Infection and neurological and cardiovascular diseases were the most frequent causes of death. Conclusion LN seems to be severe in our study, with a predominance of proliferative forms, severe renal manifestations, and poor renal and overall survival.


Nephrologie & Therapeutique | 2009

Les facteurs de progression de la néphropathie diabétique : prise en charge et évolution

Tarik Bouattar; Samir Ahid; Sakina Benasila; Mariem Mattous; Hakima Rhou; Naima Ouzeddoun; Redouane Abouqal; R. Bayahia; L. Benamar

UNLABELLED The diabetic nephropathy is among the first causes of end stage renal disease worldwide. However, the diabetics are often lately refered to the nephrologists. The goal of our study is to determine the stage of the diabetic nephropathy, its risk factors and to appreciate its evolution after a nephrology management in Morocco. METHODS Prospective study including 728 patients diabetic type 2 addressed for a nephrologic follow up between January 2000 and December 2007. We evaluated the stage of diabetic nephropathy by the dosage of the urinary albumin excretion of 24 hours and the estimation of the renal function by the creatinine clearance. Four stages have been distinguished: negative microalbuminuria, positive microalbuminuria, macroalbuminuria and renal failure. After the instauration of the measures of nephroprotection, we appreciated the evolution of this diabetic nephropathy after a minimum follow-up of six months. RESULTS The mean age of our patients was of 61,8 years. At the first consultation, 68,9% of patients had a renal failure. The diabetes duration was of 13,8 years. The unbalanced diabetes was noted at 68,7% of the patients. The risk factors of the renal failure were age, systolic arterial tension, retinopathy diabetic and anemia. After a mean follow-up of 22,4 months, the urinary albumin excretion became negative in 42,6% of the patients. The deterioration of the renal function was slow (creatinine clearance: 52,2ml versus 45,5ml/min/1,73m(2)). CONCLUSION The majority of our patients had renal failure at the first consultation, showing the late referal of the diabetics to the nephrologists, complicating their management. The early screening would permit to assure the nephroprotection.


Transplantation Proceedings | 2012

Ten Years of Renal Transplantation in a Moroccan Hospital: Results and Constraints

I. Haddiya; A. Radoui; L. Benamar; F. Ezaitouni; Naima Ouzeddoun; R. Bayahia; H. Rhou

INTRODUCTION Renal transplantation (RT) offers several advantages to end-stage renal disease (ESRD) patients, such as a better quality of life and economic benefits. This study sought to report a 10-year experience of RT in a developing country as well as the barriers to its improvement. PATIENTS AND METHODS The retrospective study included 67 patients who underwent a first RT from a related living donor (RLD) between June 1998 and December 2008. We noted pretransplantation donor and recipient parameters as well as the results and barriers to RT promotion in our country. RESULTS The mean overall age of our patients including 43 males (64.1%) and 24 females (35.8%) was 30 ± 9.6 years. Teenagers from 13 to 18 years of age represented 9% of the recipients. Immediate failure was observed in 5 cases due to vascular thrombosis (n = 3) or hyperacute rejection (n = 2). Graft and patient survival rates at 1 year were 92.6% and 97%, respectively. CONCLUSION The limited number of RT in our country may be explained by the lack of both human and material resources as well as the limited pool of living donors. Nonetheless, the economic gain subsequent to RT should encourage promotion of this treatment mainly through dissemination of information.


Nephrologie & Therapeutique | 2009

Cas cliniqueIntoxication grave à l’éthylène glycol par voie transcutanéeSevere ethylene glycol intoxication by skin absorption

Tarik Bouattar; Naoufel Madani; Hakim Hamzaoui; Zaitouna Alhamany; Abdeljalil El Quessar; L. Benamar; Hakima Rhou; Redouane Abouqual; Amine Ali Zeggwagh; Rabea Bayahia; Naima Ouzeddoun

UNLABELLED Ethylene glycol is present predominantly in antifreeze,and in industrial solvents. Accidental ingestion of ethylene glycol is relatively rare, but may be potentially lethal. It results in a depression of the central nervous system, a severe metabolic acidosis and an acute renal failure by tubular precipitation of calcium oxalate crystals. We report a case of ethylene glycol poisoning by through skin absorption. OBSERVATION A 38-year-old man, working in a cement factory, with a history of cutaneous psoriasis for 10 years, was admitted to our hospital due to acute nausea, vomiting and diffuse abdominal pain, followed by generalized convulsive status epilepticus and worsening of his mental status. Biologic analysis showed severe metabolic acidosis and acute renal failure which required hemodialysis. On renal biopsy, there were intratubular crystals of calcium oxalate. Cerebral magnetic resonance imaging showed posterior encephalitis. Evolution was marked by normalization of renal function at two weeks and improvement of the mental status. Retrospectively, the patients history-taking revealed that he manipulated ethylene glycol without gloves. CONCLUSION Cutaneous contact with ethylene glycol may cause poisoning in presence of skin lesions. The triad neurologic involvement, renal failure due to oxalate crystals deposits and metabolic acidosis leads to the diagnosis of ethylene glycol intoxication. In the case of acute renal failure with oliguria, haemodialysis is the treatment of choice. It allows the removal of the toxic substance and its metabolites with correction of the metabolic acidosis. The precocity of the treatment may improve the prognosis.


Nephrologie & Therapeutique | 2009

Intoxication grave à l’éthylène glycol par voie transcutanée

Tarik Bouattar; Naoufel Madani; Hakim Hamzaoui; Zaitouna Alhamany; Abdeljalil El Quessar; L. Benamar; Hakima Rhou; Redouane Abouqual; Amine Ali Zeggwagh; Rabea Bayahia; Naima Ouzeddoun

UNLABELLED Ethylene glycol is present predominantly in antifreeze,and in industrial solvents. Accidental ingestion of ethylene glycol is relatively rare, but may be potentially lethal. It results in a depression of the central nervous system, a severe metabolic acidosis and an acute renal failure by tubular precipitation of calcium oxalate crystals. We report a case of ethylene glycol poisoning by through skin absorption. OBSERVATION A 38-year-old man, working in a cement factory, with a history of cutaneous psoriasis for 10 years, was admitted to our hospital due to acute nausea, vomiting and diffuse abdominal pain, followed by generalized convulsive status epilepticus and worsening of his mental status. Biologic analysis showed severe metabolic acidosis and acute renal failure which required hemodialysis. On renal biopsy, there were intratubular crystals of calcium oxalate. Cerebral magnetic resonance imaging showed posterior encephalitis. Evolution was marked by normalization of renal function at two weeks and improvement of the mental status. Retrospectively, the patients history-taking revealed that he manipulated ethylene glycol without gloves. CONCLUSION Cutaneous contact with ethylene glycol may cause poisoning in presence of skin lesions. The triad neurologic involvement, renal failure due to oxalate crystals deposits and metabolic acidosis leads to the diagnosis of ethylene glycol intoxication. In the case of acute renal failure with oliguria, haemodialysis is the treatment of choice. It allows the removal of the toxic substance and its metabolites with correction of the metabolic acidosis. The precocity of the treatment may improve the prognosis.


Nephrologie & Therapeutique | 2009

Évaluation et analyse de la douleur chez les hémodialysés chroniques

Tarik Bouattar; Zoubair Skalli; Hakima Rhou; Fatima Ezzaitouni; Naima Ouzeddoun; R. Bayahia; L. Benamar

INTRODUCTION Pain is a sensorial experience and emotional discomfort associated with a potential tissue damage or described in terms evoking such injuries. Its management is a task for every physician. However, the epidemiology and characteristics of pain among chronic hemodialysis patients are incompletely defined. PURPOSE OF OUR STUDY: To evaluate the prevalence, characteristics, impact and treatment of chronic pain in chronic hemodialysis and its potential risk factors. METHODS A cross-sectional study included 67 chronic hemodialysis patients in the Ibn Sina Hospital hemodialysis center in Rabat. We evaluated the sociodemographic characteristics of patients and pain features, as well as the response to analgesics. Pain is described as chronic when it persists for more than 3 months. The pain intensity was specified by a verbal scale. RESULTS The mean age of our patients was 43.5+/-12.9 years with a feminine predominance (58.2%). The prevalence of pain was 50.7%. The pain was noticed for a mean period of 21 months (six to 60). This pain was continuous, frequent, intermittent and rare in respectively 20.6, 17.6, 47.1 and 14.7% of cases. The intensity of the pain was low in 3%, moderate in 41%, severe in 44% and very severe in 12% of cases. An osteoarticular origin was found in 76.5% of cases. A physical activity disorder was found in 67.6% of cases. Half of our patients were taking analgesics in 23.5% of cases, as daily use in 29.7% of cases frequently, and in 47.1% of cases rarely. These analgesics were level 1 in 47.1% and level 2 in 52.9% of cases. The therapeutic response is characterized by the disappearance of pain in 35.5% of cases. During dialysis sessions, pain intensity was the same in 79.4% of the patients. The risk factors associated with pain were an advanced age and a long length of time on dialysis. CONCLUSION A systematic evaluation of pain is required to improve the quality of life of hemodialysis patients.


Immunological Investigations | 2017

HLA Class II with Lupus Nephritis in Moroccan Patients.

Ouahiba Bhallil; Aicha Ibrahimi; Sanae Ouadghiri; Naima Ouzeddoun; N. Benseffaj; R. Bayahia; M. Essakalli

ABSTRACT Lupus nephritis (LN) is a disease with a poor prognosis. The association between LN and the Human leukocyte antigen (HLA) genes has never been studied on a Moroccan population. The aim of this work was to evaluate the distribution of the HLA class II alleles in patients with LN and to determine susceptible and protective HLA alleles/haplotypes in LN. The association between these alleles, disease severity of LN, and age at onset were also investigated. Seventy-five patients with LN were compared with 169 healthy unrelated controls. HLA class II alleles typing was performed by polymerase chain reaction-sequence-specific primers (PCR-SSP). A significant increase of HLA-DRB1*15 allele frequency (p = 0.001) and a significant decrease of the HLA-DRB1*04 allele (p = 0.04) were observed in LN patients. The frequency of HLA-DRB1*15-DQB1*06 haplotype (p = 0.003) was increased in the patients while that of HLA-DRB1*04-DQB1*03 (p = 0.027) was decreased. A significant increase of HLA-DRB1*15 allele frequency (p = 0.0001) and HLA-DRB1*15-DQB1*06 haplotype (p = 0.002) was observed in patients with class IV LN. In the Moroccan population we demonstrated the positive association of HLA class II alleles and haplotypes with LN and with a severe form of nephritis. HLA-DRB1*15 allele does not determine the age of disease onset in LN.


International Journal of Nephrology and Renovascular Disease | 2014

Infectious peritonitis profile in peritoneal dialysis at Ibn Sina University Hospital: a 6-year data report

S. Bekaoui; I. Haddiya; Maria slimani Houti; Fatima Zahra Berkchi; F. Ezaitouni; Naima Ouzeddoun; R. Bayahia; L. Benamar

Background Infectious peritonitis (IP) is the most common complication in peritoneal dialysis (PD). The purpose of this study is to assess the prevalence of IP and to determine its clinical, biological, and evolutive characteristics. Patients and methods We conducted a five year, five months retrospective study from July 2006 to December 2011. All patients on peritoneal dialysis that have been followed on PD for a minimum of 3 months and who presented IP during follow-up were included. Data were analyzed using SPSS 17.0. Results The 76 episodes of IP were identified in 36 patients. The peritonitis rate (months × patients/peritonitis), as calculated by the Registre de Dialyse Péritonéale de Langue Française (RDPLF Registry) [French peritoneal dialysis registry] in December 2011, was 18.59. Time to occurrence of peritonitis from the start of peritoneal exchange was 15.44±10 months. The mean age of our patients was 49.1±16.8 years [10–80]: the youngest patient’s age was 10, while the oldest was 80 years old (male to female: sex ratio M/F=1,66). Also, 22% of our patients were diabetic. The mean follow-up in PD was 22.6±14 months. Abdominal pain was present in 79% of the cases. Fever and vomiting were noted in 42% and 38% of cases, respectively. The C-reactive protein rate was elevated in 77% of cases, and leukocytosis was found in 27% of cases. Bacteriological proof was present in 73.68% of cases. Gram-positive cocci were involved in 56.6% of microbiologically proven IP cases. Gram-negative bacilli were represented in 37.7%. The outcome was favorable in 89.4%. The PD catheter was removed in 2.63% of the cases. In addition, 7.89% of our patients were transferred to hemodialysis. Discussion The rate of IP remains high in our series. More than one-half of the peritonitis cases with positive cultures (56.6%) were caused by Gram-positive cocci. Gram-negative bacilli ranked second (27.7%). These results agree with data in the literature. Moreover, the rate of culture-negative IP in our series is high (26%). Evolution is good in most cases (89%). Conclusion Despite the gradual decrease of its rate, peritonitis remains frequent in our center and calls for optimization of means of prevention. The high frequency of negative culture IP in our study urges us toward better collaboration with biologists to target antibiotic therapy and improve IP management.


Indian Journal of Human Genetics | 2012

Renal amyloidosis due to familial mediterranean fever misdiagnosed

Iman Hama; Ratbi Ilham; Naima Ouzeddoun; Zaitouna Alhamany; Radia Bayahia

Familial Mediterranean fever (FMF, MIM 249100) is an autosomal recessive disease affecting mainly patients of the Mediterranean basin. It is an autoinflammatory periodic disorder characterized by recurrent episodes of fever and abdominal pain, synovitis, and pleuritis. The major complication of FMF is the development of renal AA amyloidosis. Treatment with colchicine prevents the occurrence of recurrent seizures and renal amyloidosis. The disease is caused by mutations in the MEFV gene. We report here the cases of two unrelated patients, who have been late diagnosed with FMF complicated by renal amyloidosis. We focus on the importance of early diagnosis of FMF, both to start rapidly treatment with colchicine and avoid renal amyloidosis, and to provide genetic counseling to families.

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Zaitouna Alhamany

Faculty of Medicine and Pharmacy of Rabat

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Amine Ali Zeggwagh

Faculty of Medicine and Pharmacy of Rabat

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Naoufel Madani

Faculty of Medicine and Pharmacy of Rabat

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Nadia Cherradi

Faculty of Medicine and Pharmacy of Rabat

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A. Malihy

Boston Children's Hospital

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Lamia Rouas

Boston Children's Hospital

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Najat Lamalmi

Boston Children's Hospital

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A. Radoui

National Service of Learning

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