Nakashima T

Doxapram in the treatment of idiopathic apnea of prematurity: desirable dosage and serum concentrations

Since the introduction of aminophylline for the treatment of idiopathic apnea of prematurity, successful treatment has been documented, j,2 but more aggressive measures such as continuous positive airway pressure or mechanical ventilation may be required. Doxapram, an analeptic agent with a wide safety margin, is an effective respiratory stimulant in adults, 3 and has been used to overcome idiopathic apnea of prematurity. 4 Recently, the efficacy and safety of doxapram in premature neonates with severe idiopathic apnea resistant to treatment with aminophylline have been documented? 4 Our purpose was to determine the appropriate dosage of doxapram by measuring its serum concentrations.

The perception of dementia in the general population in Japan

*p<.05, **p<.01 y CDR-Global was not normally distributed and a Spearman’s rho evaluationwas used for correlation analysis between the CDR-Global, CST-Score and CST-time CDR-SOB (Clinical Dementia Rating Scale-Sum of Boxes, ADAS-Cog Total (Alzheimer’s Disease Assessment Scale, Cognitive Subscale Total Score), ADAS-Cog Revised (Alzheimer’s Disease Assessment Scale, Cognitive Subscale Total Score Revised), CDR-Global (Clinical Dementia Rating Scale-Global). Poster Presentations: P3 P638