Nancy Ann Hosken
Corixa Corporation
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Publication
Featured researches published by Nancy Ann Hosken.
Journal of Immunology | 2003
Christine M. Posavad; Anna Wald; Nancy Ann Hosken; Meei Li Huang; David M. Koelle; Rhoda Ashley; Lawrence Corey
During the course of investigating T cell responses to HSV among volunteers entering trials of investigational genital herpes vaccines, 6 of the 24 immunocompetent subjects with no prior history of oral/labial or genital herpes possessed HSV-specific T cell immunity but, by multiple determinants of even the most sensitive serological assays, remained seronegative to HSV-1 and -2. Of these six immune seronegative (IS; HSV-seronegative with HSV-specific T cell responses) subjects, two had transient HSV-specific T cell responses, while four had CD4+ and CD8+ T cell responses directed at HSV that persisted for up to 4 years. CD4+ T cell clones were isolated that recognized and had high binding affinities to epitopes in HSV-2 tegument proteins. All six IS subjects had potential sexual exposure to an HSV-2-infected sexual partner. Oral and genital mucosal secretions were sampled and tested for the presence of infectious HSV and HSV DNA. No evidence of HSV was detected in >1500 samples obtained from these IS subjects. The identification of persistent T cell responses to HSV in seronegative subjects is a novel finding in the herpesvirus field and suggests either undetected infection or acquired immunity in the absence of infection. Understanding the basis of these acquired immune responses may be critical in developing effective vaccines for genital herpes.
Archive | 2002
Robert M. Hershberg; Nancy Ann Hosken; Michael J. Lodes; Raodoh Mohamath
Vaccine | 2005
Nancy Ann Hosken
Archive | 2000
Tongtong Wang; Liqun Fan; Michael Kalos; Chaitanya S. Bangur; Nancy Ann Hosken; Gary R. Fanger; Samuel X. Li; Aijun Wang; Yasir A. W. Skeiky; Robert A. Henderson; Patricia D. Mcneill; Neil Fanger
Archive | 2003
Nancy Ann Hosken; Patrick Mcgowan; Paul R. Sleath; Sally Mossman; Lawrence Evans; Ryan Michael Swanson; Patricia D. Mcneill
Archive | 2003
Craig H. Day; Nancy Ann Hosken; Joseph M. Parsons
Archive | 2002
Robert M. Hershberg; Nancy Ann Hosken; Michael J. Lodes; Raodoh Mohamath
Archive | 2002
Robert M. Hershberg; Nancy Ann Hosken; Michael J. Lodes; Raodoh Mohamath
Archive | 2002
Robert M. Hershberg; Nancy Ann Hosken; Michael J. Lodes; Raodoh Mohamath
Archive | 2002
Robert M. Hershberg; Nancy Ann Hosken; Michael J. Lodes; Raodoh Mohamath