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Dive into the research topics where Nandkumar N. Bhongle is active.

Publication


Featured researches published by Nandkumar N. Bhongle.


Tetrahedron Letters | 2002

Novel diacid accelerated borane reducing agent for imines

Zhi-Hui Lu; Nandkumar N. Bhongle; Xiping Su; Seth Ribe; Chris H. Senanayake

A remarkable effect of diacids in modulating the reactivity of borane has been discovered. This novel process provides a rapid and excellent access for reduction of a variety of imines with different functionalities.


Bioorganic & Medicinal Chemistry Letters | 2008

In vitro and in vivo evaluation of O-alkyl derivatives of tramadol.

Liming Shao; Michael Charles Hewitt; Thomas P. Jerussi; Frank Xinhe Wu; Scott Christopher Malcolm; Paul Grover; Kevin Q. Fang; Patrick Koch; Chris H. Senanayake; Nandkumar N. Bhongle; Seth Ribe; Roger P. Bakale; Mark G. Currie

Tramadol is a centrally acting opioid analgesic structurally related to codeine and morphine. O-Alkyl, N-desmethyl, and non-phenol containing derivatives of tramadol were synthesized to probe their effect on metabolic stability and both in vitro and in vivo potency.


Journal of Organic Chemistry | 2000

Chiral mandelic acid template provides a highly practical solution for (S)-oxybutynin synthesis.

Paul T. Grover; Nandkumar N. Bhongle; Stephen A. Wald; Chris H. Senanayake


Archive | 2008

Dosage forms of O-desmethylvenlafaxine

Thomas P. Jerussi; Chrisantha H. Senanayake; Nandkumar N. Bhongle


Organic Letters | 2001

A New Lithium Alkoxide Accelerated Diastereoselective Cyanation of Ketones

H. Scott Wilkinson; Paul Grover; Charles P. Vandenbossche; Roger P. Bakale; Nandkumar N. Bhongle; and Stephen A. Wald; Chris H. Senanayake


Archive | 2001

Methods of treating affective disorders using derivatives of (-)-venlafaxine

Thomas P. Jerussi; Chrisantha H. Senanayake; Nandkumar N. Bhongle


Archive | 2002

Methods of treating and preventing pain, anxiety, and incontinence using derivatives of (-)-venlafaxine

Thomas P. Jerussi; Chrisantha H. Senanayake; Nandkumar N. Bhongle


Tetrahedron Letters | 2005

Efficient and scalable arylation of bicyclic lactones to form quaternary centers using conventional and microwave radiation

Scott Christopher Malcolm; Seth Ribe; Fengjiang Wang; Michael Charles Hewitt; Nandkumar N. Bhongle; Roger P. Bakale; Liming Shao


Tetrahedron-asymmetry | 2003

A large-scale asymmetric synthesis of (S)-cyclohexylphenyl glycolic acid

Xiping Su; Nandkumar N. Bhongle; Derek Pflum; Hal T. Butler; Stephen A. Wald; Roger P. Bakale; Chris H. Senanayake


Archive | 2006

Salts of (-)-O-desmethylvenlafaxine

Thomas P. Jerussi; Chrisantha H. Senanayake; Nandkumar N. Bhongle

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