Naohiko Hasegawa
Hiroshima University
Network
Latest external collaboration on country level. Dive into details by clicking on the dots.
Publication
Featured researches published by Naohiko Hasegawa.
Cell Biology International | 2007
Noriyoshi Mizuno; Hideki Shiba; Wanpeng Xu; Takafumi Inui; Tsuyoshi Fujita; Mikihito Kajiya; Katsuhiro Takeda; Naohiko Hasegawa; Hiroyuki Kawaguchi; Hidemi Kurihara
Neurotrophins (NTs) are expressed during tooth development. However, little is known about a role of NTs in differentiation of pulp cells into mineralizing cells. In this study, mRNA expressions of hard tissue‐related proteins, calcification and proliferation are examined in cultures of human pulp (HP) cells. Nerve growth factor (NGF), brain derived neurotrophic factor (BDNF), neurotrophin (NT)‐3 and NT‐4/5 increased the mRNA levels of dentin sialophsphoprotein, alkaline phosphatase, osteopontin, type I collagen and bone morphogenetic protein‐2 and mineral deposition in cultures of HP cells. The increased levels and manners varied, depending on the concentrations of NTs and hard‐tissue related protein tested. On the other hand, only NGF significantly stimulated DNA synthesis in cultures of HP cells. These findings suggest that NTs characteristically regulate hard‐tissue related protein expression, calcification and proliferation in pulp cells. NTs may accelerate pulp cell differentiation.
Journal of Periodontology | 2004
Hiroyuki Kawaguchi; Akio Hirachi; Naohiko Hasegawa; Tomoyuki Iwata; Hidenori Hamaguchi; Hideki Shiba; Takashi Takata; Yukio Kato; Hidemi Kurihara
Journal of Periodontology | 2006
Naohiko Hasegawa; Hiroyuki Kawaguchi; Akio Hirachi; Katsuhiro Takeda; Noriyoshi Mizuno; Masahiro Nishimura; Chika Koike; Koichiro Tsuji; Hideo Iba; Yukio Kato; Hidemi Kurihara
Journal of Periodontal Research | 2003
Naohiko Hasegawa; Hiroyuki Kawaguchi; Tetsuji Ogawa; Takashi Uchida; Hidemi Kurihara
Tissue Engineering | 2005
Katsuhiro Takeda; Hideki Shiba; Noriyoshi Mizuno; Naohiko Hasegawa; Yoshihiro Mouri; Akio Hirachi; Hiroshi Yoshino; Hiroyuki Kawaguchi; Hidemi Kurihara
Journal of Periodontal Research | 2003
Daisuke Fujioka; Shigeo Nakamura; Hiroshi Yoshino; Hiroaki Shinohara; Hideki Shiba; Noriyoshi Mizuno; Naohiko Hasegawa; Norihisa Shindoh; Yuushi Uchida; Tetsuji Ogawa; Hiroyuki Kawaguchi; Hidemi Kurihara
Journal of Periodontology | 2008
Noriyoshi Mizuno; Hideki Shiba; Takafumi Inui; Katsuhiro Takeda; Mikihito Kajiya; Naohiko Hasegawa; Hiroyuki Kawaguchi; Hidemi Kurihara
Journal of Periodontology | 2006
Wanpeng Xu; Noriyoshi Mizuno; Hideki Shiba; Katsuhiro Takeda; Naohiko Hasegawa; Shinitiro Yoshimatsu; Takafumi Inui; Yoshitaka Ozeki; Miyuki Niitani; Hiroyuki Kawaguchi; Koichiro Tsuji; Yukio Kato; Hidemi Kurihara
Clinical calcium | 2005
Hiroyuki Kawaguchi; Hideaki Hayashi; Noriyoshi Mizuno; T. Fujita; Naohiko Hasegawa; Hideki Shiba; Shigeo Nakamura; Takamune Hino; Hiroshi Yoshino; Hidemi Kurihara; Tanaka H; Kimura A; Koichiro Tsuji; Yukio Kato
Archive | 2004
Hidemi Kurihara; Hiroyuki Kawaguchi; Katsuhiro Takeda; Hideki Shiba; Noriyoshi Mizuno; Hiroshi Yoshino; Naohiko Hasegawa; Hiroaki Shinohara
