Naohiro Kobayashi

CLINICOPATHOLOGICAL ANALYSIS OF GASTRIC MUCOSAL CANCER INVADING LYMPH VESSELS OR THE VEINS OF THE STOMACH WALL

In total, 573 lesions were resected from 518 patients with primary gastric mucosal cancer in Hiroshima City Hospital over the last 20 years, and the patients with ly(+) or v(+) lesions were analyzed from the clinicopathological point of view. The results were as follows. 1) 17 patients (3.0%) had ly(+) lesions, 3 (0.6%) had v(+) lesions. 2) In all but one case the lesions were located in the M or A area. 3) In all cases except two the lesions were depressed or mixed type. 4) Although one lesion was pap, the others were sig or tub 1, 2. However, there were no significant differences between the differentiated and undifferentiated types. 5) The maximal tumor diameter ranged from 1.5cm in the n(+) cases, but in the ly(+) cases from 0.7cm less than those cases. 6) 12 patients had n(+). Although 7 of the latter had ly(+), there were 3 n(+) cases even among the ly(-) cases. Furthermore, the 10 cases had depressive compartment. 7) Two patients died of another disease and one died of bone metastasis. The other patients are all alive. These results indicate that gastrectomy with node dissection should be done for the depressed or mixed type of lesion which has the possibility of being not only n(+) but also ly(+), v(+) even in the case of mucosal cancer.

CLINICAL SIGNIFICANCE OF TUMOR MARKERS IN BREAST CANCER

CA15-3, NCC-ST-439, BCA225 and CEA were measured in patients with breast cancer and the clinical significance of the these tumor markers were studied on. In primary breast cancers, the positive rates of them were 11_??_14%. With an advance in the stage of the disease, the positive rate for each marker increased, but in stages I and II the positive rate was low, indicating that these markers were unsatisfactory for screening. In recurrent cases following surgery for breast cancer, all the tumor markers showed a positive rate higher than that in non-recurrent cases. The positive rates of tumor markers at the time when definite diagnosis of recurrent cancer was made were high in the liver and bone, but low in lymph nodes, skin and thoracic wall. Organ specificity of these tumor markers could not be confirmed. The positive rates in recurrent breast cancers increased with combination assay, suggesting that tumor marker determination is extremely useful for postoperative screening. In particular, the positive rates of CEA and CA15-3 showed the highest value of 66.0% and the correlation was also, low, indicating that the combination is satisfactory.