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Featured researches published by Naohisa Fukuda.


Brain Research | 1968

Responses of posterior hypothalamic neurons to electrical stimulation of the inferior alveolar nerve and distension of stomach with cold and warm water

Shuji Takaori; Masashi Sasa; Naohisa Fukuda

Summary Responses of neurons in the posterior hypothalamus to electrical stimulation of the inferior alveolar nerve and distension of the stomach with cold and warm water were studied in encephale isolepreparations of cats. The mean firing rate of spontaneous unit discharges of the hypothalamic neurons was6.2 ± 2.9 (S.E.)/sec. About half of the units showed the pattern of exponential distribution, and the other half exhibited the distribution with 2–4 modes, gamma distribution atλ = 2, and rectangular distribution. More than half of the hypothalamic neurons responded to electrical stimulation of the inferior alveolar nerve at 20 c/sec in frequency, and the increased response dominated in the responsive neurons. The decreased response and biphasic responde were also found. Most of the units responsive to the somatosensory stimulation responded to the intragastric infusion of cold water but not warm water. The interval histogram of unit discharges was also modified by the infusion of cold water. It is concluded that the posterior hypothalamic neurons respond nonspecifically to afferent forms of stimulation.


Acta Oto-laryngologica | 1971

Responses of Single Neurons of the Vestibular Nuclei to Lateral Tilt and Caloric Stimulation in the Intact and Hemilabyrinthectomized Cats

Izuru Matsuoka; Naohisa Fukuda; Shuji Takaori; Masanori Morimoto

Responses of unitary discharges of the vestibular nuclei to lateral tilt and caloric stimulation were studied in the unanesthetized encephale isole preparations of intact and hemilabyrinthectomized cats. The responses of firing rate of 93 units to lateral tilt were classified into 5 groups: increased type. (increase with lateral tilt to either or both directions), decreased type (decrease with lateral tilt to either or both directions), reversed type-I (increase with ipsilateral and decrease with contralateral tilt), reversed type-II (decrease with ipsilateral and increase with contralateral tilt), and refractory type (refractory with lateral tilt to both directions). The most dominant pattern of the responses to lateral tilt was the decreased type (60.2%). On the other hand, more than half of the vestibular units (61.3%) showed reverse changes in frequency to caloric stimulation with cold and warm water. Two main types of units were localized in the vestibular nuclei: one increased the frequency in respo...


Neuropharmacology | 1968

The mechanism of antagonism between apomorphine and metoclopramide on unit discharges from nuclear structures in the brainstem of the cat

Shuji Takaori; Yoshihisa Nakai; Izuru Matsuoka; Masashi Sasa; Naohisa Fukuda; Kiro Shimamoto

Abstract Effects of apomorphine and metoclopramide were studied on the spontaneous unit discharges in the single neurons of nuclear structures of brainstem in the ence´phale isole´preparations of cats. Apomorphine increased significantly the spontaneous discharge frequencies of single neurons in the Nucleus tractus solitarii, but did not influence the frequencies in the Nucleus vestibularis lateralis and Nucleus sensorius superior n. trigemini and the number of spikes per volley in the inspiratory unit discharges. Metoclopramide decreased significantly the firing rate of unit discharges in the Nucleus tractus solitarii and Nucleus vestibularis lateralis, while the unit discharges of the Nucleus sensorius superior n. trigemini and the rhythmic unit discharges corresponding to inspiration were not modified by metoclopramide. The acceleration of spontaneous discharge frequencies of the Nucleus tractus solitarii induced by apomorphine was completely blocked by the supplement of metoclopramide. Metoclopramide prevented retching and vomiting elicited by electrical stimulation of the Nucleus tractus solitarii. In some animals, metoclopramide produced a transient alert pattern in the cortical and hippocampal EEG and depressed slightly the recruiting response. However, it did not affect the reticular arousal response and the evoked click potentials in the auditory cortex.


Folia Pharmacologica Japonica | 1979

Thyrotropin-releasing hormone(TRH):一側線条体破壊動物におけるDopamine性旋回運動増強ならびにTRH自体の旋回運動作用

Naohisa Fukuda; Masaomi Miyamoto; Shigehiko Narumi; Yasuo Nagai; Takashi Shima; Yuji Nagawa


Japanese Journal of Pharmacology | 1969

Effects of aminopyrine and phenylbutazone on the activity of neurons in the trigeminal nuclei and hypothalamus.

Masashi Sasa; Naohisa Fukuda; Shuji Takaori


Folia Pharmacologica Japonica | 1984

Physiological and biochemical study of temporary cerebral ischemic rats produced by bilateral vertebral and carotid artery occlusion

Yomei Take; Naoki Yamazaki; Naohisa Fukuda; Yoshiaki Saji; Yuji Nagawa


Japanese Journal of Pharmacology | 1970

Mode of action of chlorpromazine on unit discharges from nuclear structures in the brainstem of cats.

Shuji Takaori; Naohisa Fukuda; Yasuko Amano


Japanese Journal of Pharmacology | 1974

NEUROPHARMACOLOGICAL STUDIES OF EFFECT OF NEW CENTRAL DEPRESSANT, 8-CHLORO-6-PHENYL-4H-s-TRIAZOLO [4, 3-a] [1, 4] BENZODIAZEPINE (D-40TA) ON EEG AND CENTRAL SYMPATHETIC ACTIVATING MECHANISM IN CATS

Naohisa Fukuda; Yoshiaki Saji; Yuji Nagawa


Japanese Journal of Pharmacology | 1969

THE MODE OF HYPOTENSIVE ACTIONS OF 2-(2, 6-DICHLOROPHENYL-L-AMINO)-IMIDAZOLINE IN THE RABBIT

Noboru Toda; Naohisa Fukuda; Kiro Shimamoto


Neuroscience Research Supplements | 1986

The development and characteristics of spontaneous seizures in amygdala kindled rats

Tadatoshi Hashimoto; Naohisa Fukuda; Yoshiaki Saji; Yuji Nagawa

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Yuji Nagawa

Takeda Pharmaceutical Company

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Masahiko Fujino

Takeda Pharmaceutical Company

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Masaomi Miyamoto

Takeda Pharmaceutical Company

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