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Dive into the research topics where Naoki Sakane is active.

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Featured researches published by Naoki Sakane.


Clinical and Experimental Pharmacology and Physiology | 2002

Effects of caffeine on the uncoupling protein family in obese yellow KK mice.

Akinori Kogure; Naoki Sakane; Yasuto Takakura; Tsunekazu Umekawa; Keiji Yoshioka; Hoyoku Nishino; Takayuki Yamamoto; Teruo Kawada; Toshikazu Yoshikawa; Toshihide Yoshida

1.u2002The hypothesis that caffeine upregulates uncoupling protein (UCP)‐1, UCP‐2 and UCP‐3 expression, which contribute to thermogenesis, was investigated in obese mice.


Peptides | 2005

Proinsulin C-peptide activates vagus efferent output in rats

Kazuhiro Kimura; A. Niijima; R. Yoshida; Takanori Kitamura; Akihiro Kamikawa; Daniela Tomie Furuya; Naoki Kitamura; Akihiro Konno; Hiroshi Nakamoto; Naoki Sakane; Toshihide Yoshida; Masayuki Saito

The aim of this study was to examine the effect of proinsulin C-peptide on the autonomic nervous systems in rats. Intravenous administration of C-peptide gradually increased electrophysiological activity of the vagus nerves into the stomach and pancreas for at least 90 min. It also slightly increased gastric acid secretion that was suppressed by the treatment with atropine. Intraperitoneal injection of C-peptide did not affect the basal and stress-induced norepinephrine (NE) turnover rate, a biochemical index of sympathetic nerve activity. These results indicate that C-peptide increases parasympathetic nerve activity without affecting sympathetic nerve activity. This could explain, at least in part, the ameliorating effects of C-peptide on impaired cardiac autonomic nerve functions in patients with type 1 diabetes.


The Journal of Nuclear Medicine | 2002

123I- or 125I-Metaiodobenzylguanidine Visualization of Brown Adipose Tissue

Chio Okuyama; Naoki Sakane; Toshihide Yoshida; Keiji Shima; Hiroyuki Kurosawa; Kenzo Kumamoto; Yo Ushijima; Tsunehiko Nishimura


Metabolism-clinical and Experimental | 2005

The effect of a high-carbohydrate meal on postprandial thermogenesis and sympathetic nervous system activity in boys with a recent onset of obesity

Narumi Nagai; Naoki Sakane; Taku Hamada; Tetsuya Kimura; Toshio Moritani


Biochemical and Biophysical Research Communications | 2002

Expression and functional analyses of novel mutations of ATP-binding cassette transporter-1 in Japanese patients with high-density lipoprotein deficiency

Yoshiharu Nishida; Kenichi Hirano; Kosuke Tsukamoto; Makoto Nagano; Chiaki Ikegami; Kirsten Roomp; Mitsuaki Ishihara; Naoki Sakane; Zhongyan Zhang; Kenichi Tsujii; Akifumi Matsuyama; Tohru Ohama; Fumihiko Matsuura; Masato Ishigami; Naohiko Sakai; Hisatoyo Hiraoka; Hiroaki Hattori; Cheryl L. Wellington; Yoshihide Yoshida; Susumu Misugi; Michael R. Hayden; Toru Egashira; Shizuya Yamashita; Yuji Matsuzawa


Metabolism-clinical and Experimental | 2007

Association of Pro12Ala polymorphism in the peroxisome proliferator-activated receptor γ2 gene with small dense low-density lipoprotein in the general population

Taku Hamada; Kazuhiko Kotani; Kokoro Tsuzaki; Yoshiko Sano; Takashi Murata; Masahiko Tabata; Shigeaki Sato; Naoki Sakane


Journal of Nutritional Science and Vitaminology | 2005

Metabolic Responses to High-Fat or Low-Fat Meals and Association with Sympathetic Nervous System Activity in Healthy Young Men

Narumi Nagai; Naoki Sakane; Toshio Moritani


Diabetes Research and Clinical Practice | 2004

Effects of sex, age and BMI on screening tests for impaired glucose tolerance

Mioko Gomyo; Naoki Sakane; Isao Kamae; Shigeaki Sato; Ken-Ichi Suzuki; Makoto Tominaga; Shoji Kawazu; Hideyo Yoshinaga; Kazuyo Tsushita; Juichi Sato; Yuzo Sato; Satoru Tsujii; Toshihide Yoshida; Yutaka Seino; Takeshi Usui; Kishio Nanjo; Mari Hirata; Kazuhiko Kotani; Arimasa Hososako; Yutaka Kiyohara; Hideshi Kuzuya


Journal of Nutritional Science and Vitaminology | 2006

Impact of aging and β3 -adrenergic -receptor polymorphism on thermic and sympathetic responses to a high-fat meal

Narumi Nagai; Naoki Sakane; Toshio Moritani


Archives of Medical Research | 2004

Risk factors for silent cerebral infarction in the elderly.

Kazuhiko Kotani; Yoneatsu Osaki; Naoki Sakane; Seiji Adachi; Yasutaka Ishimaru

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Toshihide Yoshida

Kyoto Prefectural University of Medicine

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Seiji Adachi

Memorial Hospital of South Bend

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