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Dive into the research topics where Naoko Asaoka is active.

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Featured researches published by Naoko Asaoka.


Respirology | 2004

Clinical features of Q fever pneumonia

Niro Okimoto; Naoko Asaoka; Kohichi Osaki; Takeyuki Kurihara; Kenji Yamato; Takako Sunagawa; Kazue Fujita; Hideo Ohba; Junichi Nakamura; Keiichi Nakada

Abstract:  The aim of the study was to assess the clinical features of Q fever pneumonia in Japan. Four cases of Q fever pneumonia (a female aged 21 and males aged 53, 74 and 87 years) who were diagnosed using the PanBio ELISA test kit, were assessed and their clinical features are described. The frequency of Q fever pneumonia among our cases of community‐acquired pneumonia was 1.4% (4/284). A 21‐year‐old female had a typical case of the disease with (i) a history of owning a cat, (ii) onset with fever and dry cough, (iii) multiple soft infiltrative shadows on CXR, (iv) a normal white blood cell count, and (v) good response to clarithromycin. The pneumonias in the other three cases were considered mixed infections with bacteria such as Streptococcus pneumoniae and Haemophilus influenzae. Their clinical features included the following: (i) an elderly person with an underlying disease, (ii) onset with fever and purulent sputum, (iii) coarse crackles on auscultation, (iv) infiltrative shadows and pleural effusion on CXR, (v) increased white blood cells with elevated BUN and hyponatraemia, and (vi) modest responses to combined therapy with carbapenem and minocycline. Our observations suggest that two types of pneumonia caused by Coxiella burnetti exist; one with the usual features of atypical pneumonia, and the other presenting with the clinical features of bacterial pneumonia in the elderly due to mixed bacterial infection.


Journal of Infection and Chemotherapy | 2009

Procalcitonin and severity of community-acquired pneumonia

Niro Okimoto; Yoshikiyo Hayashi; Mitsunori Ishiga; Fumiyo Nanba; Michihiro Kishimoto; Shinichi Yagi; Takeyuki Kurihara; Naoko Asaoka; Sadao Tamada

The purpose of this study was to clarify the relationship between procalcitonin and the severity and prognosis of community-acquired pneumonia. The subjects were 162 patients with community-acquired pneumonia (disease severity, mild, 39 patients; moderate, 81 patients; severe, 37 patients; and super severe, 5 patients) in whom we examined the serum procalcitonin concentration at the start of treatment; we determined the relationship of procalcitonin status with disease severity and prognosis. The results showed that procalcitonin was positive in 12.8% of the patients with mild disease, 27.1% of the patients with moderate disease, 59.5% of the patients with severe disease, and 80.0% of the patients with super severe disease. The mortality of procalcitonin-positive patients was 37.7%, whereas that of the procalcitonin-negative patients was 12.8%. Based on the above findings, it is concluded that the more severe the community-acquired pneumonia, the higher is the positivity rate for procalcitonin, and the prognosis in procalcitonin-positive patients is worse than that in procalcitonin-negative patients.


Respirology | 2006

Clinical predictors for the detection of community-acquired pneumonia in adults as a guide to ordering chest radiographs

Niro Okimoto; Kenji Yamato; Takeyuki Kurihara; Yoshihiro Honda; Kohichi Osaki; Naoko Asaoka; Kazue Fujita; Hideo Ohba

Objective:  To identify sensitive clinical predictors for the detection of community‐acquired pneumonia in adults as a guide to when to order a CXR.


Journal of Infection and Chemotherapy | 2010

Clinical features of Proteus mirabilis pneumonia

Niro Okimoto; Toshikiyo Hayashi; Mitsunori Ishiga; Fumiyo Nanba; Michihiro Kishimoto; Shinichi Yagi; Takeyuki Kurihara; Naoko Asaoka; Sadao Tamada

In this study, we clinically reviewed 13 patients with Proteus mirabilis pneumonia who were admitted for treatment to Kawasaki Medical School Kawasaki Hospital, Okayama, Japan, between April 2006 and July 2009. Clinical features were retrospectively reviewed. Results showed that: (1) hospital-acquired pneumonia occurred in elderly patients with underlying diseases such as cerebrovascular disease; (2) some patients had complications of urinary tract infection due to P. mirabilis; (3) preadministration of antibacterial agents did not become a risk factor; (4) resistance for levofloxacin (LVFX) was observed; (5) prognosis was comparatively good (effective rate 84.7%).


Respirology | 2007

Coxiella burnetii and acute exacerbations/infections in patients with chronic lung disease

Niro Okimoto; Takashi Kibayashi; Kimihiro Mimura; Kenji Yamato; Takeyuki Kurihara; Yoshihiro Honda; Kohichi Osaki; Naoko Asaoka; Hideo Ohba

The aim of the present study was to determine the incidence of Q fever in patients with an acute exacerbation of a chronic lower respiratory tract infection. Eighty patients treated for acute exacerbation of chronic lower respiratory tract infections during a 30‐month period were studied. Q fever was diagnosed by ELISA. Two elderly woman with pre‐existing bronchiectasis (2.5%) were diagnosed as having an acute infection by Coxiella burnetii. The acute illness was considered to be a result of mixed infection with Pseudomonas aeruginosa and Haemophilus influenzae with C. burnetii. Co‐infection with C. burnetii can occur during a bacterial exacerbation of a chronic lower respiratory tract infection.


Journal of Infection and Chemotherapy | 2010

Clinical features of Escherichia coli pneumonia

Niro Okimoto; Toshikiyo Hayashi; Mitsunori Ishiga; Fumiyo Nanba; Michihiro Kishimoto; Shinichi Yagi; Takeyuki Kurihara; Naoko Asaoka; Sadao Tamada

Escherichia coli pneumonia was clinically reviewed. Twenty-two patients with E. coli pneumonia were admitted for treatment to Kawasaki Medical School Kawasaki Hospital, between January 2006 and December 2008. Clinical features were retrospectively reviewed. Results showed that: (1) hospital-acquired pneumonia occurred in elderly patients with underlying diseases, such as cerebrovascular disease, diabetes mellitus, or chronic obstructive pulmonary disease; (2) more patients had complications of urinary-tract infection or alimentary infection due to E. coli; (3) previous administration of antibacterial agents did not become a risk factor; (4) resistance to ampicillin (ABPC) and levofloxacin (LVFX) was observed; and (5) mortality was 22.7%.


Microbes and Infection | 2006

Roles of neuraminidase in the initial stage of influenza virus infection.

Masanobu Ohuchi; Naoko Asaoka; Tatsuya Sakai; Reiko Ohuchi


Microbes and Infection | 2006

Low growth ability of recent influenza clinical isolates in MDCK cells is due to their low receptor binding affinities

Naoko Asaoka; Yasuko Tanaka; Tatsuya Sakai; Yutaka Fujii; Reiko Ohuchi; Masanobu Ohuchi


Journal of Infection and Chemotherapy | 2003

Clinical effect of ampicillin with β-lactamase inhibitor (sulbactam/ampicillin) on community-acquired pneumonia in the elderly

Niro Okimoto; Takeyuki Kurihara; Nobuhiro Honda; Naoko Asaoka; Kazue Fujita; Hideo Ohba; Junichi Nakamura


Journal of Infection and Chemotherapy | 2005

Clinical effect of intravenous ciprofloxacin on hospital-acquired pneumonia

Niro Okimoto; Kenji Yamato; Yoshihiro Honda; Takeyuki Kurihara; Kohichi Osaki; Naoko Asaoka; Kazue Fujita; Hideo Ohba

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Niro Okimoto

Kawasaki Medical School

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Hideo Ohba

Kawasaki Medical School

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Kazue Fujita

Kawasaki Medical School

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Kenji Yamato

Kawasaki Medical School

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