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Naoto Hashimoto

Takeda Pharmaceutical Company

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Publication

Featured researches published by Naoto Hashimoto.

Journal of The Chemical Society, Chemical Communications | 1972

ββ-Dichloro-α-aminoacrylonitrile

Koichi Matsumura; Takahiro Saraie; Naoto Hashimoto

Dichloroacetonitrile reacts with HCN to give the title compound, an enamine, acylation of which, followed by treatment with amines, provides a new synthesis of oxazoles.

Archive | 1982

9-Thiomaytansinoids and their pharmaceutical compositions and use

Naoto Hashimoto; Hiroshi Shimadzu

Archive | 1978

Method for the production of maytansinoids

Naoto Hashimoto; Toyokazu Kishi

Archive | 1979

Matansinol 3-n-hexadecanoate

Naoto Hashimoto; Toyokazu Kishi

Archive | 1979

1,2-Di-Substituted-4-haloimidazole-5-acetic acid derivatives and their use

Koichi Matsumura; Naoto Hashimoto; Yoshiyasu Furukawa

The Journal of Antibiotics | 1992

Studies on condensed-heterocyclic azolium cephalosporins. IV. Synthesis and antibacterial activity of 7 beta-[2-(5-amino-1,2,4-thiadiazol-3-yl)-2(Z)- alkoxyiminoacetamido]-3-(condensed-heterocyclic azolium)methyl cephalosporins including SCE-2787.

Akio Miyake; Yoshinobu Yoshimura; Masayoshi Yamaoka; Tatsuo Nishimura; Naoto Hashimoto; Akira Imada

Chemical & Pharmaceutical Bulletin | 1984

Chemical Modification of Ansamitocins. III. Synthesis and Biological Effects of 3-Acyl Esters of Maytansinol

Akiyoshi Kawai; Hiroshi Akimoto; Yoshio Kozai; Koichiro Ootsu; Seiichi Tanida; Naoto Hashimoto; Hiroaki Nomura

The Journal of Antibiotics | 1992

Studies on condensed-heterocyclic azolium cephalosporins. V. Synthesis and antibacterial activity of 3-(condensed-triazolo-pyridinium, -pyrimidinium, and -pyridazinium)-methyl cephalosporins.

Yoshinobu Yoshimura; Kiminori Tomimatsu; Tatsuo Nishimura; Akio Miyake; Naoto Hashimoto

Chemical & Pharmaceutical Bulletin | 1981

Studies on fluorinated pyrimidines. I. A new method of synthesizing 5-fluorouracil and its derivatives.

Osamu Miyashita; Koichi Matsumura; Hiroshi Shimadzu; Naoto Hashimoto

Chemical & Pharmaceutical Bulletin | 1976

Studies of Nitriles. X. Synthesis and Reactions of 2-Acylamino-3, 3-bis-(substituted mercapto) acrylonitriles and Their Derivatives. A New Synthesis of 2-Substituted-5-(substituted mercapto) oxazole-4-carbonitriles and Their Derivatives

Koichi Matsumura; Osamu Miyashita; Hiroshi Shimadzu; Naoto Hashimoto

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Katsura Morita

Takeda Pharmaceutical Company

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Koichi Matsumura

University of Wisconsin-Madison

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Hiroshi Shimadzu

Takeda Pharmaceutical Company

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Osamu Miyashita

Takeda Pharmaceutical Company

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Toyokazu Kishi

Takeda Pharmaceutical Company

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Koichi Matsumura

University of Wisconsin-Madison

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Akio Miyake

Takeda Pharmaceutical Company

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Tatsuo Nishimura

Takeda Pharmaceutical Company

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Yoshinobu Yoshimura

Takeda Pharmaceutical Company

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Takahiro Saraie

Takeda Pharmaceutical Company

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