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Dive into the research topics where Naoto Ueyama is active.

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Featured researches published by Naoto Ueyama.


Bioorganic & Medicinal Chemistry Letters | 1994

Cycloheptimidazole based angiotensin II receptor antagonists. 4,5,6,7-Tetrahydro-8-carboxymethylidene cycloheptimidazoles

Naoto Ueyama; Takashi Yanagisawa; Baba Hiromi; Kuroiwa Keiko; Hayashi Hiromi; Sonegawa Motoharu; Tomiyama Tsuyoshi

Abstract 4,5,6,7-Tetrahydro-8-carboxymethylidene-cycloheptimidazoles were synthesized as potential angiotensin II (AII) receptor antagonists. One of these, 10b, KT-3866, showed a pD′ 2 value of 9.91 and was about 5 times more potent than KT 3-671 in an vivo study and had long lasting inhibitory action on AII-induced pressor response in rats at a dose of 0.3 mg/kg.


Chemical & Pharmaceutical Bulletin | 1994

Nonpeptide Angiotensin II Receptor Antagonists. I. Synthesis and Biological Activity of Pyridine Derivatives

Naoto Ueyama; Takashi Yanagisawa; Tomoyuki Kawai; Motoharu Sonegawa; Hiromi Baba; Seiichiro Mochizuki; Kazuhiro Kosakai; Tsuyoshi Tomiyama


Archive | 1993

Cycloheptimidazole derivatives, method of manufacturing the same and therapeutic agents containing these compounds

Tsuyoshi Tomiyama; Akira Tomiyama; Takashi Yanagisawa; Naoto Ueyama; Tomoyuki Kawai; Motoharu Sonegawa; Hiromi Baba; Makoto Haketa


Archive | 1999

Isoquinuclidine derivatives, method of manufacturing the same and therapeutic agents for hypercholesterolemia containing these compounds

Tsuyoshi Tomiyama; Akira Tomiyama; Takeyuki Imamaki; Naoto Ueyama; Motoharu Sonegawa; Satoru Takeuchi


Yakugaku Zasshi-journal of The Pharmaceutical Society of Japan | 1996

[New intracellular calcium antagonists. I. Synthesis and pharmacological evaluation of 2,3,4,5-tetrahydro-1,5-benzothiazepine analogs].

Naoto Ueyama; Shuichi Wakabayashi; Tsuyoshi Tomiyama


Chemical & Pharmaceutical Bulletin | 1997

Change of Mechanical Activity to Contraction from the Relaxation Induced by the Intracellular Ca2+ Antagonist KT-362; Effects of Alkylation of Side Chain, and Substitution of 2, 3, 4, 5-Tetrahydro-1, 5-Benzothiazepine Derivatives

Naoto Ueyama; Shyuichi Wakabayashi; Tsuyoshi Tomiyama


Archive | 1994

Carboxymethylidenecycloheptimidazole derivatives, method of manufacturing the same and therapeutic agents containing these compounds

Tsuyoshi Tomiyama; Akira Tomiyama; Takashi Yanagisawa; Naoto Ueyama; Hiromi Baba


Chemical & Pharmaceutical Bulletin | 1986

Reaction of Phosphorus Oxyacid Esters with p-Toluenesulfonic Acid

Yoshihiro Nitta; Yasushi Arakawa; Naoto Ueyama


Archive | 2001

3-Substituted-2-halocycloheptenone compounds and a method for manufacturing same

Tsuyoshi Tomiyama; Akira Tomiyama; Naoto Ueyama; Akira Ohno


Journal of Labelled Compounds and Radiopharmaceuticals | 1995

Synthesis of [14C]KT3‐671, 2‐Propyl‐8‐oxo‐1‐[ (2′‐(1H‐[14C] tetrazole‐5‐yl) biphenyl‐4‐yl) methyl]‐4,5,6, 7‐tetrahydro‐cycloheptimidazole, a novel potent nonpeptide angiotensin II receptor antagonist

Naoto Ueyama; Takashi Yanagisawa; Tsuyoshi Tomiyama

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Takashi Yanagisawa

National Institute of Radiological Sciences

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Yoshihiro Nitta

Chugai Pharmaceutical Co.

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