Narenchaoketu Han

A biflavonoid glycoside from Lomatogonium carinthiacum (Wulf) Reichb

A biflavonoid glycoside with a new carbon skeleton, named carinoside A, was isolated from the n-BuOH crude extract of the whole plant of Lomatogonium carinthiacum (Wulf) Reichb. The structure of the new compound was elucidated by using spectroscopic methods, including UV, IR, HR-ESI-MS and extensive 1D and 2D NMR techniques.

The structural elucidation and antimicrobial activities of two new monoterpene glucoside derivatives from Lomatogonium carinthiacum (Wulf) Reichb.

Lomatogonium carinthiacum (Wulf) Reichb (L. carinthiacum), Habirigendigeda in Mongolian, a species of the genus Lomatogonium, is distributed throughout Inner Mongolia, Shanxi, Xinjiang of China, and is used as a remedy for plague, influenza, typhoid, liver disease, and jaundice in Mongolian medicine. Terpenoids and flavonoids have been reported from L. carinthiacum. The terpenoidsterpenoids exhibited significant pharmacological activities including anti-inflammatory and cytotoxicity against A 549 lung carcinoma, WI-38 lung fibroblast, VA-13 lung malignant tumor, and HepG2 human liver tumor cells, which are consistently used in Mongolian clinics. In the course of a search for antimicrobial active compounds, the ethanol extract of the whole plant of L. carinthiacum was investigated. The current paper describes the isolation and structure elucidation of two monoterpene glucoside derivatives, and their antimicrobial activities are reported.

The Structure Elucidation and Antimicrobial Activities of Nonsterol Triterpenoids from Ixeris chinensis

Abstract An investigation of the petroleum ether extract from Ixeris chinensis Nakai has led to the isolation of a new compound, 3-O-acetyl-22,28-cyclobauer-7-en-3β-ol (1), together with four known compounds which have been isolated from this plant for the first time, namely taraxast-20-en-3β-ol (2), 3-O-acetyl-taraxast-20-en-3β-ol (3), taraxast-20(30)-en-3β-ol (4), and 3-O-acetyl-taraxast-20(30)- en-3β-ol (5). The structures of the isolated compounds have been elucidated on the basis of spectroscopic methods including UV, IR, ESI-MS, 1D NMR, 2D NMR techniques, and by comparison with data reported in the literature. All compounds have been evaluated for their activity against various bacteria and shown to give good results

A new sesquiterpene from Ixeris chinensis

The petroleum ether (PE) extract from Ixeris chinensis was submitted to chromatographic separation. A new sesquiterpene, namely 14-noreudesma-3-hydroxy-3-en-2,9-dione, was isolated from the PE extract. The structures of the sesquiterpene was elucidated by using spectroscopic methods, including UV, IR, HR-ESI-MS and extensive 1D and 2D NMR techniques.

Anti-inflammatory effects and structure elucidation of flavonoid and biflavonoid glycosides from Artemisia frigida Willd

Flavonoid and biflavonoid glycosides have been isolated from the n-BuOH extract of Artemisia frigida Willd. This is the first report on the structure elucidation of two new compounds based on spectroscopic methods including ultraviolet (UV), infrared (IR), ESI–MS, 1D and 2D NMR techniques. The new compounds were investigated for their effect against inflammation induced by egg albumin and carrageenan in rats.Graphical abstract.

Three flavonoids from the leaves of Astragalus membranaceus and their antifungal activity

A new flavonoid and two known flavonoids were isolated from the EtOAc extract of the leaves of Astragalus membranaceus (Fisch) Bge. var. mongholicus (Bge) Hsiao (A.membranaceus). This is the first report on the structure elucidation of the new compound based on spectroscopic methods including UV, IR, ESI-MS, 1D NMR, and 2D NMR techniques. The isolated compounds exhibited antifungal activity against different Fusarium oxysporum f.sp. dianthi pathotypes.Graphical abstract

Anti-inflammatory effect and isolation of phenylethanoid and acylated flavone glycosides from Panzeria alaschanica

Abstract The phytochemical study of the EtOAc extract from Panzeria alaschanica resulted in the isolation of two new acylated flavone glycosides, 5,7,4′-trihydroxyflavone-7-O-(6″-O-[E]-coumaroyl)-β-glucopyranoside (1) and 5,7,4′-trihydroxyflavone-7-O-(2″,6″-O-[E]-dicoumaroyl)-β-glucopyranoside (2), as well as of a known phenylethanoid (verbascoside, 3). The structure of the isolated compounds was elucidated by spectroscopic methods, including ultraviolet spectrophotometry, infrared absorption spectroscopy, electrospray ionization mass spectrometry and 1D nuclear magnetic resonance spectroscopy, and by comparison with those reported in the literature. All compounds were investigated for their effect against inflammation induced by egg albumin and carrageenan in rats.

Anti-inflammatory and analgesic effects of two new flavone C-glycosides from Panzeria alaschanica

Two new flavone C-glycosides, named as panzeroside A and B were isolated from the n-BuOH crude extract of the aerial parts of Panzeria alaschanica Kuprian. Their structures were elucidated by spectroscopic methods, including UV, IR, ESI–MS, 1D NMR, and 2D NMR techniques. Anti-inflammatory and analgesic activities of were assessed in rats by the hot plate test, paw pressure, and carrageenan-induced paw oedema. The two new compounds showed significant and dose-dependent analgesic and anti-inflammatory effects.Graphical abstract

A new alkaloid from Helianthemum ordosicum.

Helianthemum ordosicum, the relict plant of the third century, is a member of the family Cistaceae, genus Helianthemum and distributed predominantly at rocky low mountain and gravelly hill of Zhuozi and Gangdegeer mountain, Inner Mongolia. H. ordosicum is the second-grade state protection plant, only one genus in China. It plays not only an important role in themaintenance of the desert ecosystem but also in the special academic value and practicing significance for the study of environmental evolution, flora, biological evolution, biodiversity and global change. Up to now, several studies have been reported including taxonomy, palynology, tissue culture, embryology, morphology, population ecology and physiological ecology. However, there are few reported phytochemistry studies. Recently, we carried out a systematic chemical study on the CHCl3 extract from the stem of H. ordosicum, which resulted in the isolation of a new alkaloid with a new carbon skeleton. Here, we report the structural characterization of the new compound by spectral analysis.

Analgesic effects and structural elucidation of two new flavone C-glycosides from Artemisa sacrorum

The present study was designed to isolate and characterize the analgesic compounds of Artemisa sacrorum Ledeb. The EtOAc crude extracts from the aerial parts of Artemisa sacrorum Ledeb were separated by chromatography and the structures of new compounds were elucidated based on spectral analyses. Analgesic activities of the isolated compounds were assessed in rats with hot plate test and paw pressure assay. Two new flavone C-glycosides, named as Sacroroside A and B (Compounds 1 and 2) were isolated from the EtOAc crude extract of the aerial parts ofArtemisa sacrorum Ledeb. They showed significant analgesic effects. In conclusion, Compounds 1 and 2 are new natural products, which show significant analgesic effects in a dose-dependent manner.